> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/plozasiran-db7fc1a9-8c66-49a1-b91f-50b904e75d8e > Record changed: 2026-10-13 # Plozasiran Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068438) Drug type Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068438) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068438) ## Names and chemistry **Drug type** Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068438) **Drug name** Plozasiran Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068438) ### Other names (12) - ads 005 - ads 005 free acid - ADS-005 - ADS-005 FREE ACID - plozasiran - Plozasiran - plozasiran \[INN\] - PLOZASIRAN \[USAN\] - Plozasiran \[WHO-DD\] - plozasiran inn - plozasiran usan - plozasiran who dd ## Identifiers **ATC classification codes** - C10AX **CAS registry numbers** - 2379776-40-4 **ChEMBL ID** CHEMBL6068438 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068438) **RxNorm IDs (RxCUI)** - 2727175 **FDA ingredient codes (UNII)** - XG9ARL6P25 ## Regulatory information ### European Union **Status** Authorised **Status date** 19 Jun 2026 **Authorisation date** 19 Jun 2026 **Approved indications** Redemplo is indicated as an adjunct to diet to reduce triglyceride levels in adult patients with familial chylomicronaemia syndrome (FCS) (see section 4.2 for patient selection criteria). **Product number** EMEA/H/C/006579 **Authorisation holder** Arrowhead Pharmaceuticals Ireland Limited **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** Yes **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Hyperlipoproteinemia Type I European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/redemplo) ### Other regulatory facts **Patents** 0 **Designations** 5 **First in class** No **Fast track** Yes **Breakthrough designation** Yes **Orphan designation** Yes **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Pharmacology name** plozasiran **Type** Nucleic acid **Approval recorded by Guide to Pharmacology** Yes ### Investigated indications (3) - **Condition** Hypertriglyceridemia **Highest recorded phase** 1 **Condition identifier** EFO:0004211 **Subject identifier** D015228 - **Condition** Dyslipidemias **Highest recorded phase** 1 **Condition identifier** HP:0003119 **Subject identifier** D050171 - **Condition** Hyperlipoproteinemia Type I **Highest recorded phase** 1 **Condition identifier** MONDO:0009387 **Subject identifier** D008072 ### Open Targets indications (9) - **Condition identifier** EFO\_0004211 **Highest recorded phase** 3 - **Condition identifier** HP\_0003119 - **Condition identifier** MONDO\_0002525 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005347 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0006515 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0009387 - **Condition identifier** MONDO\_0009387 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0018637 **Highest recorded phase** 3 - **Condition identifier** Orphanet\_79211 **Highest recorded phase** 2 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences - **Component** Sequence **Type** Nucleic Acid **Sequence** (3'-5') U-G-C-C-C-U-G-U-C-A-U-A-A-G-A-G-U-C=A=C=U (5'-3') A-C-G-G-G-A-C-A-G-U-A-U-U-C-U-C-A-G-U-I-A ## National Drug Codes - 84141-025 ## Related records ### Trials (8) - A Phase 3 Study of ARO-APOC3 / VSA001 / SAR449124 (Plozasiran) in Chinese Adults With Familial Chylomicronemia Syndrome - Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia - [Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia](https://trialight.com/data/trial/phase-3-study-of-plozasiran-in-adults-with-269663de-8c63-4987-99ce-1c0b6168a61e.md) - Study of ARO-APOC3 (Plozasiran) in Adults With Familial Chylomicronemia Syndrome (FCS) - Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia - Study of Plozasiran in Adults With Severe Hypertriglyceridemia - Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis - Treatment Protocol of Plozasiran in Adults With High-Risk Severe Hypertriglyceridemia (SHTG) and in Adults and Adolescents With FCS ### In development for (2) - Familial lipoprotein lipase deficiency Phase 1 - [Hypertriglyceridemia](https://trialight.com/data/condition/hypertriglyceridemia-538285c3-ad71-513e-bd58-6cc97634acb2.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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