> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/plixorafenib-2fa70ff1-9eee-4187-9de1-ed7740bd8dec
> Record changed: 2026-11-04

# Plixorafenib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4303729)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4303729)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4303729)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4303729)

**Drug name**

Plixorafenib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4303729)

**Molecular weight**

542.54

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4303729)

**Structure (SMILES)**

O=C(c1c(F)ccc(NS(=O)(=O)N2CC\[C@@H\](F)C2)c1F)c1c\[nH\]c2ncc(-c3cnc(C4CC4)nc3)cc12

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4303729)

### Other names (17)

- fore 8394
- FORE-8394
- fore8394
- FORE8394
- plixorafenib
- Plixorafenib
- plixorafenib \[INN\]
- PLIXORAFENIB \[USAN\]
- plixorafenib inn
- plixorafenib usan
- plx 8394
- Plx 8394
- PLX 8394 \[WHO-DD\]
- plx 8394 who dd
- Plx-8394
- plx8394
- PLX8394

## Identifiers

**CAS registry numbers**

- 1393466-87-9

**ChEMBL ID**

CHEMBL4303729

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4303729)

**InChIKey**

YYACLQUDUDXAPA-MRXNPFEDSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4303729)

**PubChem compound IDs**

- 90116675

**FDA ingredient codes (UNII)**

- J2L7Z273SG

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

plixorafenib

**Type**

Synthetic organic

**Drug name stem**

\-rafenib

### Mechanisms of action (3)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
Raf-1 proto-oncogene, serine/threonine kinase

**Gene symbol**  
RAF1

**Protein identifier**  
P04049

**Median affinity**

7.64

**Affinity units**  
pIC50
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
B-Raf proto-oncogene, serine/threonine kinase

**Gene symbol**  
BRAF

**Protein identifier**  
P15056

**Median affinity**

7.85

**Affinity units**  
pIC50
- **Mechanism**  
Serine/threonine-protein kinase B-raf inhibitor

**Action type**  
Inhibitor

**Target**  
Serine/threonine-protein kinase B-raf

**Protein identifier**  
P15056

### Open Targets mechanisms

- **Mechanism**  
Serine/threonine-protein kinase B-raf inhibitor

**Action type**  
Inhibitor

**Target**  
Serine/threonine-protein kinase B-raf

### Investigated indications (9)

- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Melanoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000756

**Subject identifier**  
D008545
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Cholangiocarcinoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005221

**Subject identifier**  
D018281
- **Condition**  
Leukemia, Hairy Cell

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1000956

**Subject identifier**  
D007943
- **Condition**  
Histiocytosis

**Highest recorded phase**  
1

**Condition identifier**  
HP:0100727

**Subject identifier**  
D015614
- **Condition**  
Thyroid Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0002108

**Subject identifier**  
D013964
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0005575

**Subject identifier**  
D015179

### Open Targets indications (14)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000756
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0005221

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1000956

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0100727

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002108

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002108

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018935

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0021042

**Highest recorded phase**  
1

### Trial references (3)

- NCT02012231  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02012231)
- NCT02428712  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02428712)
- NCT05503797  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05503797)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

2

**Polar surface area**

120.94

**Calculated partition coefficient (ALogP)**

4.11

**Calculated partition coefficient (XLogP)**

2.8

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

7

**Heavy atoms**

38

**Molecular formula**

C25H21F3N6O3S

**Monoisotopic mass**

542.13479421

**Natural product**

No

## Evidence counts

**Recorded assays**

331

**Active assays**

60

### Active assay types (3)

- Confirmatory
- Other
- Screening

## Related records

### Trials (6)

- A Study of FORE8394 as a Single Agent in Patients With Advanced Unresectable Solid Tumors
- A Study of the Effects of Food and Cobicistat on Plixorafenib Pharmacokinetics in Healthy Participants.
- [A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations](https://trialight.com/data/trial/a-study-to-assess-the-efficacy-and-safety-of-fore8394-in-e38dbe6d-f238-4691-ba02-3a77f114b027.md)
- A Trial to Evaluate CSF ctDNA and Safety of Plixorafenib Alone or With Retifanlimab in Patients With BRAF-altered Glioma
- Biomarker-guided RAdiation-deferring Treatment in Younger GBM Patients - Pilot Study
- Phase I/IIa Study to Evaluate the Safety, PK, PD, and Preliminary Efficacy of PLX8394 in Patients With Advanced Cancers.

### In development for (10)

- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 1
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 1
- [Glioma](https://trialight.com/data/condition/glioma-4ac240c4-7ffb-5f08-b793-0b205a4b5d03.md) Phase 1
- [Hairy cell leukemia](https://trialight.com/data/condition/hairy-cell-leukemia-f53c6c12-084e-500e-b5b6-35769701ecdb.md) Phase 1
- Histiocytosis Phase 1
- [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 1
- [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) Phase 2
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 1
- [Thyroid cancer](https://trialight.com/data/condition/thyroid-cancer-44afb6a8-b88e-5e18-b9fd-7b51661c2c23.md) Phase 1

### Targets (2)

- [BRAF](https://trialight.com/data/target/braf-d7fd2910-24ea-5f05-9b83-3cd3e5d8bbdd.md) Serine/threonine-protein kinase B-raf inhibitor
- [RAF1](https://trialight.com/data/target/raf1-0ec15c38-cbfa-5a16-b6ab-f12c16356dd7.md)

---

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