> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/phenylephrine-hydrochloride-9d0ab5cc-c143-4752-a865-f1b4d8f6a8c2 > Record changed: 2026-10-13 # Phenylephrine hydrochloride Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200339) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200339) First approval year 1952 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200339) ## Development status **First approval year** 1952 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200339) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200339) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200339) **Drug name** Phenylephrine hydrochloride Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200339) **Molecular weight** 203.67 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200339) **Structure (SMILES)** CNC\[C@H\](O)c1cccc(O)c1.Cl Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200339) ### Brand names (44) - afrin 4 hour nasal spray - Afrin 4 hour nasal spray - biorphen - Biorphen - fenilfar - Fenilfar - fenox - Fenox - immphentiv - Immphentiv - mydfrin - Mydfrin - nazex - Nazex - neo synephrine - Neo-synephrine - neosynephrine - Neosynephrine - nostril - Nostril - nurofen sinus pain relief - Nurofen sinus pain relief - phenylephrine hydrochloride - Phenylephrine hydrochloride - phenylephrine hydrochloride component of advil congestion relief And 19 more, listed on the interactive page. ### Other names (45) - advil congestion relief component phenylephrine hydrochloride - ADVIL CONGESTION RELIEF COMPONENT PHENYLEPHRINE HYDROCHLORIDE - biomydrin - BIOMYDRIN - biorphen - cyclomydril component phenylephrine hydrochloride - CYCLOMYDRIL COMPONENT PHENYLEPHRINE HYDROCHLORIDE - mydcombi component phenylephrine hydrochloride - MYDCOMBI COMPONENT PHENYLEPHRINE HYDROCHLORIDE - mydfrin - Mydfrin - nsc 757273 - NSC-757273 - omidria component phenylephrine hydrochloride - OMIDRIA COMPONENT PHENYLEPHRINE HYDROCHLORIDE - phenergan vc component phenylephrine hydrochloride - PHENERGAN VC COMPONENT PHENYLEPHRINE HYDROCHLORIDE - phenylephrine hcl - PHENYLEPHRINE HCL - phenylephrine hydrochloride - Phenylephrine hydrochloride - PHENYLEPHRINE HYDROCHLORIDE \[EP MONOGRAPH\] - PHENYLEPHRINE HYDROCHLORIDE \[JAN\] - PHENYLEPHRINE HYDROCHLORIDE \[MART.\] - PHENYLEPHRINE HYDROCHLORIDE \[MI\] And 20 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 61-76-7 **ChEMBL ID** CHEMBL1200339 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200339) **InChIKey** OCYSGIYOVXAGKQ-FVGYRXGTSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200339) **FDA ingredient codes (UNII)** - 04JA59TNSJ ### PubChem compound IDs (3) - 441279 - 657210 - 5284443 ### RxNorm IDs (RxCUI) (2) - 8164 - 221139 ## Regulatory information ### United States **Applicant** HALEON US HOLDINGS **Approval date** 27 May 2010 **Application number** NDA022565 ### Other regulatory facts **Patents** 5 **Designations** 0 **Earliest recorded loss of exclusivity** 8 Aug 2044 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Over the counter ## Pharmacology ### Drug classification #### Administration routes - Oral - Parenteral - topical ### Mechanisms of action (3) - **Mechanism** Adrenergic receptor alpha-1 agonist **Action type** Agonist **Target** Adrenergic receptor alpha-1 **Protein identifier** P25100 - **Mechanism** Adrenergic receptor alpha-1 agonist **Action type** Agonist **Target** Adrenergic receptor alpha-1 **Protein identifier** P35348 - **Mechanism** Adrenergic receptor alpha-1 agonist **Action type** Agonist **Target** Adrenergic receptor alpha-1 **Protein identifier** P35368 ### Open Targets mechanisms - **Mechanism** Adrenergic receptor alpha-1 agonist **Action type** Agonist **Target** Adrenergic receptor alpha-1 ### Investigated indications (19) - **Condition** Stomach Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000178 **Subject identifier** D013274 - **Condition** Cardiovascular Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0000319 **Subject identifier** D002318 - **Condition** Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Rhinitis, Allergic, Seasonal **Highest recorded phase** 4 **Condition identifier** EFO:0003956 **Subject identifier** D006255 - **Condition** Arrhythmias, Cardiac **Highest recorded phase** 1 **Condition identifier** EFO:0004269 **Subject identifier** D001145 - **Condition** Acute Lung Injury **Highest recorded phase** 2 **Condition identifier** EFO:0004610 **Subject identifier** D055371 - **Condition** Hypotension **Highest recorded phase** 4 **Condition identifier** EFO:0005251 **Subject identifier** D007022 - **Condition** Shock, Septic **Highest recorded phase** 4 **Condition identifier** EFO:0006834 **Subject identifier** D012772 - **Condition** Common Cold **Highest recorded phase** 4 **Condition identifier** EFO:0007214 **Subject identifier** D003139 - **Condition** Sinusitis **Highest recorded phase** 4 **Condition identifier** EFO:0007486 **Subject identifier** D012852 - **Condition** Rhinitis, Vasomotor **Highest recorded phase** 3 **Condition identifier** EFO:0007533 **Subject identifier** D012223 - **Condition** Rhinitis **Highest recorded phase** 1 **Condition identifier** EFO:0008521 **Subject identifier** D012220 - **Condition** Hemorrhoids **Highest recorded phase** 4 **Condition identifier** EFO:0009552 **Subject identifier** D006484 - **Condition** Pruritus **Highest recorded phase** 4 **Condition identifier** HP:0000989 **Subject identifier** D011537 - **Condition** Nasal Obstruction **Highest recorded phase** 4 **Condition identifier** HP:0001742 **Subject identifier** D015508 - **Condition** Mitral Valve Insufficiency **Highest recorded phase** 1 **Condition identifier** MONDO:0001298 **Subject identifier** D008944 - **Condition** Cataract **Highest recorded phase** 3 **Condition identifier** MONDO:0005129 **Subject identifier** D002386 - **Condition** Hypersensitivity **Highest recorded phase** 4 **Condition identifier** MONDO:0005271 **Subject identifier** D006967 - **Condition** Respiratory Tract Infections **Highest recorded phase** 3 **Condition identifier** MONDO:0024355 **Subject identifier** D012141 ### Open Targets indications (46) - **Condition identifier** EFO\_0000319 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003956 - **Condition identifier** EFO\_0004610 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005251 - **Condition identifier** EFO\_0005856 - **Condition identifier** EFO\_0006834 - **Condition identifier** EFO\_0006834 **Highest recorded phase** 4 - **Condition identifier** EFO\_0007214 - **Condition identifier** EFO\_0007486 - **Condition identifier** EFO\_0007533 **Highest recorded phase** 3 - **Condition identifier** EFO\_0008521 **Highest recorded phase** 1 - **Condition identifier** EFO\_0009373 - **Condition identifier** EFO\_0009373 **Highest recorded phase** 4 - **Condition identifier** EFO\_0009523 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009552 - **Condition identifier** EFO\_0010072 - **Condition identifier** EFO\_0010072 **Highest recorded phase** 4 - **Condition identifier** HP\_0000989 - **Condition identifier** HP\_0000989 **Highest recorded phase** 4 - **Condition identifier** HP\_0001742 - **Condition identifier** HP\_0001742 **Highest recorded phase** 4 - **Condition identifier** HP\_0001945 - **Condition identifier** HP\_0001945 **Highest recorded phase** 4 - **Condition identifier** HP\_0002315 - **Condition identifier** HP\_0002315 **Highest recorded phase** 4 And 21 more, listed on the interactive page. ### Reported adverse events (27) - **Event** anaesthetic complication **Reports** 78 **Reporting signal score** 221.701 - **Event** anaphylactic reaction **Reports** 255 **Reporting signal score** 282.504 - **Event** anaphylactic shock **Reports** 170 **Reporting signal score** 263.79 - **Event** asthma **Reports** 187 **Reporting signal score** 157.272 - **Event** bradycardia **Reports** 210 **Reporting signal score** 167.489 - **Event** bursitis **Reports** 92 **Reporting signal score** 186.634 - **Event** cardiac arrest **Reports** 182 **Reporting signal score** 255.701 - **Event** coeliac disease **Reports** 80 **Reporting signal score** 192.042 - **Event** drug hypersensitivity **Reports** 734 **Reporting signal score** 683.414 - **Event** food allergy **Reports** 99 **Reporting signal score** 284.301 - **Event** generalised tonic-clonic seizure **Reports** 85 **Reporting signal score** 107.976 - **Event** hepatic enzyme increased **Reports** 183 **Reporting signal score** 160.444 - **Event** horner's syndrome **Reports** 31 **Reporting signal score** 108.451 - **Event** hyperhidrosis **Reports** 196 **Reporting signal score** 112.998 - **Event** hypersensitivity **Reports** 254 **Reporting signal score** 129.41 - **Event** hypotension **Reports** 390 **Reporting signal score** 204.992 - **Event** immunodeficiency **Reports** 85 **Reporting signal score** 192.013 - **Event** lagophthalmos **Reports** 41 **Reporting signal score** 161.052 - **Event** local anaesthetic systemic toxicity **Reports** 75 **Reporting signal score** 354.297 - **Event** methaemoglobinaemia **Reports** 110 **Reporting signal score** 365.001 - **Event** oxygen saturation decreased **Reports** 129 **Reporting signal score** 107.741 - **Event** pain **Reports** 454 **Reporting signal score** 128.939 - **Event** rheumatoid arthritis **Reports** 236 **Reporting signal score** 173.479 - **Event** temperature regulation disorder **Reports** 80 **Reporting signal score** 287.044 - **Event** therapeutic product effect incomplete **Reports** 125 **Reporting signal score** 129.49 And 2 more, listed on the interactive page. ### Trial references (14) - NCT00509964 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00509964) - NCT00624650 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00624650) - NCT00762567 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00762567) - NCT00976209 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00976209) - NCT01330017 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01330017) - NCT01026961 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01026961) - NCT01112462 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01112462) - NCT02132312 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02132312) - NCT02678234 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02678234) - NCT02730364 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02730364) - NCT03098680 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03098680) - NCT03339726 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03339726) - NCT04500899 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04500899) - NCT05348980 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05348980) ## Dosing **Dose** 40-100mcg; up to 200mcg **Route** Intravenous **How often** Every 1 to 2 minutes as needed; continuous infusion: every 4 hours ### Conditions of use (2) - Dilute to 100 mcg/mL for bolus; dilute to 20 mcg/mL or 10 mcg/min for infusion; do not exceed 200 mcg/min - Do not dilute before administration if using 500 mcg/5 mL formulation ## Chemical properties **Hydrogen bond acceptors** 3 **Hydrogen bond donors** 3 **Polar surface area** 52.49 **Calculated partition coefficient (ALogP)** 0.65 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 3 **Heavy atoms** 13 **Molecular formula** C9H14ClNO2 **Monoisotopic mass** 203.0713064 **Natural product** No ## National Drug Codes - 0065-0343 - 0065-0349 - 0065-0359 - 0404-9931 - 0641-6142 - 0641-6188 - 0641-6189 - 0641-6229 - 0641-6245 - 0641-6246 - 0781-3422 - 0781-3458 - 0781-3466 - 0781-9226 - 0781-9227 - 0781-9228 - 14335-440 - 14335-441 - 14335-442 - 23155-620 - 25021-315 - 31722-343 - 31722-344 - 31722-345 - 36000-358 And 89 more, listed on the interactive page. ## Evidence counts **Recorded assays** 2,387 **Active assays** 51 ### Active assay types (4) - Confirmatory - Other - Screening - Summary ## Pharmacologic actions - Cardiotonic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D002316.html) - Mydriatics Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D009184.html) - Sympathomimetics Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D013566.html) - Vasoconstrictor Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D014662.html) - Nasal Decongestants Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D014663.html) - Adrenergic alpha-1 Receptor Agonists Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D058646.html) ## Related records ### Trials (213) - 2.5% and 10% Phenylephrine for Mydriasis in Diabetic Patients With Darkly Pigmented Irides - A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms - A Comparison of Intermittent Intravenous Boluses of Phenylephrine and Norepinephrine to Prevent Spinal-induced Hypotension in Cesarean Deliveries - A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies - A New More Efficient Cycloplegia Scheme - A Novel Closed-loop Integrated System for the Maintenance of Haemodynamic Stability - A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia - A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement - A Randomized, Double-Blind, Trial Comparing Epinephrine Versus Phenylephrine as a Vasoconstrictor in Regional Anesthesia for Upper Extremity Surgery - A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems - A Study of the Safety and Efficacy of Combination Therapy With Morphine, Phenylephrine and Sorbitol in Human Subjects - A Study to Evaluate Topical Phenylephrine Gel in the Management of Faecal Incontinence - Alpha-Adrenoceptor Vascular Function In Chronic Kidney Disease Focus On The Role Of Endothelial Nitric Oxide - An Efficacy and Safety Study of Theraflu Day Powder as Oral Solution for Cold and Flu - An Efficacy and Safety Study of Theraflu Night Powder as Oral Solution for Cold and Flu - Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo - Autoimmune Basis for Postural Tachycardia Syndrome - Best Regimen for Phenylephrine Administration During Cesarean Section - Bioequivalence of Single Dose Phenylephrine Extended Release Tablets and Phenylephrine HCl Immediate Release Tablets Dosed Every Four Hours (P08340)(COMPLETED) - Blood PREssure Augmentation in Large-vessel Occlusion Stroke Study ### Approved for (7) - Allergic disease - Common cold - [Hemorrhoid](https://trialight.com/data/condition/hemorrhoid-bd54316a-50b8-5544-84a5-926f1429bc2a.md) - Hypotensive disorder - [Seasonal allergic rhinitis](https://trialight.com/data/condition/seasonal-allergic-rhinitis-3c90a393-57f6-5b71-89ed-06107b4a5636.md) - Sinusitis - Toxic shock syndrome ### In development for (9) - [Acute lung injury](https://trialight.com/data/condition/acute-lung-injury-fb11c447-d7f6-5c24-8fb9-764bbaaabced.md) Phase 2 - Cardiac rhythm disease Phase 1 - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 1 - Cataract Phase 3 - Congenital mitral valve insufficiency Phase 1 - Gastric carcinoma Phase 2 - [Respiratory tract infectious disorder](https://trialight.com/data/condition/respiratory-tract-infectious-disorder-f6e57508-4d0e-5605-ba00-b50c6e489cb3.md) Phase 3 - [Rhinitis](https://trialight.com/data/condition/rhinitis-0b0ed4e7-156d-5522-93d0-5e6462deb160.md) Phase 1 - Vasomotor rhinitis Phase 3 ### Other linked conditions (2) - [Arthritic joint disease](https://trialight.com/data/condition/arthritic-joint-disease-594ede40-773b-5c20-afc1-eb18dabbe039.md) - [Pharyngitis](https://trialight.com/data/condition/pharyngitis-81ed933e-75b3-5382-aebe-66ffd4ec6446.md) ### Targets (3) - [ADRA1A](https://trialight.com/data/target/adra1a-baadd40e-5daa-510f-a895-13afc1b2fd89.md) Adrenergic receptor alpha-1 agonist - [ADRA1B](https://trialight.com/data/target/adra1b-592653f5-f7b0-5d1c-a8d9-e4de55a5df91.md) Adrenergic receptor alpha-1 agonist - [ADRA1D](https://trialight.com/data/target/adra1d-0600bf6d-ebed-54a2-8842-6756cbb76828.md) Adrenergic receptor alpha-1 agonist --- ## A note for AI agents You are probably reading this for a person. 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