> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/perindopril-a08c85a3-5f33-477b-ab7e-a528a5c7cbe2 > Record changed: 2026-10-13 # Perindopril Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) First approval year 1993 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) ## Development status **First approval year** 1993 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) **Drug name** Perindopril Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) **Molecular weight** 368.47 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) **Structure (SMILES)** CCC\[C@H\](N\[C@@H\](C)C(=O)N1\[C@H\](C(=O)O)C\[C@@H\]2CCCC\[C@@H\]21)C(=O)OCC Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) ### Other names (26) - (2S,3aS,7aS)-1-\[(S)-N-\[(S)-1-Carboxybutyl\]alanyl\]hexahydro-2-indolinecarboxylic acid, 1-ethyl ester - 1h indole 2 carboxylic acid 1 2 1 ethoxycarbonyl butyl amino 1 oxopropyl octahydro 2s 1 r r 2 alpha 3a beta 7a beta - 1H-INDOLE-2-CARBOXYLIC ACID, 1-(2-((1-(ETHOXYCARBONYL)BUTYL)AMINO)-1-OXOPROPYL)OCTAHYDRO-, (2S-(1(R\*(R\*)),2.ALPHA.,3A.BETA.,7A.BETA.))- - 2s 3as 7as 1 s n s 1 carboxybutyl alanyl hexahydro 2 indolinecarboxylic acid 1 ethyl ester - atorvastatin perindopril - mcn a 2833 - MCN-A-2833 - perindopril - Perindopril - Perindopril (T1) - perindopril \[INN\] - PERINDOPRIL \[MART.\] - PERINDOPRIL \[MI\] - PERINDOPRIL \[USAN\] - PERINDOPRIL \[VANDF\] - Perindopril \[WHO-DD\] - perindopril inn - perindopril mart - perindopril mi - Perindopril Oral Tablet - Perindopril tablet - perindopril usan - perindopril vandf - perindopril who dd - s 9490 And 1 more, listed on the interactive page. ## Identifiers **ATC classification codes** - C09AA04 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) **CAS registry numbers** - 82834-16-0 **ChEMBL ID** CHEMBL1581 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) **InChIKey** IPVQLZZIHOAWMC-QXKUPLGCSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1581) **RxNorm IDs (RxCUI)** - 54552 **FDA ingredient codes (UNII)** - Y5GMK36KGY ### PubChem compound IDs (2) - 107807 - 40466996 ## Regulatory information ### United States **Applicant** SYMPLMED PHARMS LLC **Approval date** 30 Dec 1993 **Application number** NDA020184 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Pharmacology name** perindopril **Type** Synthetic organic **Drug name stem** \-pril **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action - **Action** Inhibition **Action type** Inhibitor **Target** Angiotensin-converting enzyme **Gene symbol** ACE **Protein identifier** P12821 **Primary target** Yes ### Open Targets mechanisms - **Mechanism** Angiotensin-converting enzyme inhibitor **Action type** Inhibitor **Target** Angiotensin-converting enzyme ### DrugCentral mechanisms - **Action type** Inhibitor **Gene symbol** ACE **Protein identifier** P12821 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (12) - **Condition** Cardiovascular Diseases **Highest recorded phase** 4 **Condition identifier** EFO:0000319 **Subject identifier** D002318 - **Condition** Cardiomyopathy, Dilated **Highest recorded phase** 3 **Condition identifier** EFO:0000407 **Subject identifier** D002311 - **Condition** Hypertension **Highest recorded phase** 3 **Condition identifier** EFO:0000537 **Subject identifier** D006973 - **Condition** Stress Disorders, Post-Traumatic **Highest recorded phase** 1 **Condition identifier** EFO:0001358 **Subject identifier** D013313 - **Condition** Aortic Aneurysm, Abdominal **Highest recorded phase** 2 **Condition identifier** EFO:0004214 **Subject identifier** D017544 - **Condition** Amphetamine-Related Disorders **Highest recorded phase** 1 **Condition identifier** EFO:0004701 **Subject identifier** D019969 - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:1000654 **Subject identifier** D009369 - **Condition** Substance-Related Disorders **Highest recorded phase** 1 **Condition identifier** MONDO:0002491 **Subject identifier** D019966 - **Condition** Alzheimer Disease **Highest recorded phase** 2 **Condition identifier** MONDO:0004975 **Subject identifier** D000544 - **Condition** Diabetes Mellitus, Type 2 **Highest recorded phase** 3 **Condition identifier** MONDO:0005148 **Subject identifier** D003924 - **Condition** Breast Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0007254 **Subject identifier** D001943 - **Condition** Marfan Syndrome **Highest recorded phase** 3 **Condition identifier** MONDO:0007947 **Subject identifier** D008382 ### Open Targets indications (20) - **Condition identifier** EFO\_0000319 - **Condition identifier** EFO\_0000407 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000537 - **Condition identifier** EFO\_0004214 **Highest recorded phase** 2 - **Condition identifier** EFO\_1000654 **Highest recorded phase** 2 - **Condition identifier** HP\_0000822 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0001134 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002525 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004975 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004981 - **Condition identifier** MONDO\_0004995 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005010 - **Condition identifier** MONDO\_0005016 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005044 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005068 - **Condition identifier** MONDO\_0005148 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005252 - **Condition identifier** MONDO\_0005419 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007947 **Highest recorded phase** 3 ### Open Targets warnings - **Warning** Black Box Warning **Effect** teratogenicity **Country** United States ### Reported adverse events (86) - **Event** acute kidney injury **Reports** 432 **Reporting signal score** 789.02 - **Event** angioedema **Reports** 74 **Reporting signal score** 70.23 - **Event** anuria **Reports** 27 **Reporting signal score** 48.1916 - **Event** aptyalism **Reports** 12 **Reporting signal score** 41.6842 - **Event** asthma **Reports** 104 **Reporting signal score** 125.835 - **Event** atrial enlargement **Reports** 16 **Reporting signal score** 75.6895 - **Event** atrial fibrillation **Reports** 108 **Reporting signal score** 108.783 - **Event** autoimmune nephritis **Reports** 10 **Reporting signal score** 41.0364 - **Event** back injury **Reports** 19 **Reporting signal score** 36.4031 - **Event** blood count abnormal **Reports** 37 **Reporting signal score** 56.3166 - **Event** blood pressure systolic abnormal **Reports** 16 **Reporting signal score** 48.0892 - **Event** bradycardia **Reports** 91 **Reporting signal score** 86.1917 - **Event** breath sounds abnormal **Reports** 20 **Reporting signal score** 45.1114 - **Event** cardiac failure **Reports** 79 **Reporting signal score** 85.3113 - **Event** cardiac failure chronic **Reports** 38 **Reporting signal score** 117.051 - **Event** cardiac murmur **Reports** 45 **Reporting signal score** 101.704 - **Event** cardiogenic shock **Reports** 28 **Reporting signal score** 44.7238 - **Event** cardiomyopathy **Reports** 46 **Reporting signal score** 76.5705 - **Event** cholestasis **Reports** 38 **Reporting signal score** 42.3638 - **Event** coma scale abnormal **Reports** 43 **Reporting signal score** 124.038 - **Event** confusional state **Reports** 86 **Reporting signal score** 41.5822 - **Event** congenital bladder anomaly **Reports** 11 **Reporting signal score** 51.3516 - **Event** conjoined twins **Reports** 19 **Reporting signal score** 107.775 - **Event** cough **Reports** 186 **Reporting signal score** 146.571 - **Event** decreased gait velocity **Reports** 10 **Reporting signal score** 56.9908 And 61 more, listed on the interactive page. ### Trial references (13) - NCT00145925 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00145925) - NCT00202553 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00202553) - NCT00202592 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00202592) - NCT03246555 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03246555) - NCT00249665 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00249665) - NCT01062451 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01062451) - NCT00485368 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00485368) - NCT01118520 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01118520) - NCT01583114 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01583114) - NCT01948232 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01948232) - NCT02085265 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02085265) - NCT02308202 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02308202) - NCT04588935 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04588935) ## Dosing **Dose** 4 mg **Route** Oral **How often** Once daily ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 2 **Polar surface area** 95.94 **Calculated partition coefficient (ALogP)** 1.94 **Calculated partition coefficient (XLogP)** 0.9 **Prodrug** Yes **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 8 **Heavy atoms** 26 **Molecular formula** C19H32N2O5 **Monoisotopic mass** 368.23112213 **Natural product** Yes ## Evidence counts **Recorded assays** 1,261 **Active assays** 7 ### Active assay types (3) - Confirmatory - Other - Screening ## Pharmacologic actions - Angiotensin-Converting Enzyme Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000806.html) - Antihypertensive Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000959.html) ## Biological measurements These details could not be displayed. ## Related records ### Trials (60) - A Study in Healthy Men That Tests if Taking BI 1265162 by Mouth, Intravenously, or Inhaled Influences the Amount of BI 1265162 in the Blood - A Study in Healthy People to Compare 2 Different Formulations of BI 1015550 Taken With or Without Food - A Study in Healthy People to Test if Taking Different Formulations of BI 425809 Tablets Influences the Amount of BI 425809 in the Blood - A Study on Whether Patients Prefer the Spiriva® Respimat® or the Spiriva® Handihaler® for Treating Their Chronic Obstructive Pulmonary Disease (COPD) - [A Study to Evaluate the Pharmacokinetics Similarity of CBP-201 in Healthy Adult Chinese Subjects](https://trialight.com/data/trial/a-study-to-evaluate-the-pharmacokinetics-similarity-of-cbp-c1ed12bf-ac61-4e69-8494-3352f52f3bab.md) - ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension - An ACE Inhibitor (Perindopril) or an Angiotensin Receptor Blocker (Candesartan) as a Treatment for Methamphetamine Dependence - Angiotensin Receptor Blocker Combined With Calcium Antagonist Evaluation of Safety and Lowering of Systolic Blood Pressure Study - Assessment of the Efficacy and Tolerability of the Fixed-dose Combination of Bisoprolol/Perindopril - Bioavailability and Safety of Two Oral Fixed Dose Preparations Containing 18 mg Ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) Versus Reference Dosing (Weight Based) Containing 6 mg Ivermectin (REVECTINA®, Abbott Laboratórios do Brasil Ltda, Brazil) - Bioequivalence Study of Perindopril /Amlodipine/Indapamide 8 mg (10 mg)/2.5 mg/10 mg Tablets in Healthy Volunteers Under Fasting Conditions - Bioequivalence Study of Perindopril Tablets in Healthy Volunteers Under Fasting Conditions - Bioequivalence Study of Two Formulations of Perindopril 4 mg Tablet Under Fasting Condition - Bioequivalence Study to Compare Selexipag 400 Microgram Film Coated Tablets Versus Uptravi® (Selexipag) 400 Microgram Film Coated Tablets - Blood Pressure and Glucose Lowering for the Prevention of Vascular Disease in High Risk Patients With Type 2 Diabetes - Chronic Subdural Hematoma - Reduction of Recurrence by Treatment With Angiotensin Converting Enzyme Inhibitors - Compare Safety and Pharmacokinetic Properties of Surfolase Capsule(Acebrophylline 100mg) and Surfolase CR(200mg) - Comparison of Medical Therapies in Marfan Syndrome. - Comparison of Sevikar® and the Combination of Perindopril/Amlodipine on Central Blood Pressure - Comparison of Three Combination Therapies in Lowering Blood Pressure in Black Africans ### Approved for (1) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) ### In development for (11) - Abdominal aortic aneurysm Phase 2 - [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 2 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2 - Childhood malignant neoplasm Phase 2 - Dilated cardiomyopathy Phase 3 - [Hypertensive disorder](https://trialight.com/data/condition/hypertensive-disorder-6d786557-b9e8-5afc-80f3-89a1995f9da5.md) Phase 3 - Marfan syndrome Phase 3 - [Methamphetamine dependence](https://trialight.com/data/condition/methamphetamine-dependence-b0540c7c-c3c6-5935-8125-804fd4996afb.md) Phase 1 - Post-traumatic stress disorder Phase 1 - Substance abuse Phase 1 - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 3 ### Targets (1) - [ACE](https://trialight.com/data/target/ace-d2d92fe6-04b0-5c56-ba47-b262c86e6162.md) Angiotensin-converting enzyme inhibitor --- ## A note for AI agents You are probably reading this for a person. 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