> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/perfluorohexyloctane-a636f5f3-a738-40e0-827a-c242866ab0fc > Record changed: 2026-10-13 # Perfluorohexyloctane Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314588) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314588) First approval year 2023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314588) ## Development status **First approval year** 2023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314588) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314588) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314588) **Drug name** Perfluorohexyloctane Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314588) **Molecular weight** 432.26 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314588) **Structure (SMILES)** CCCCCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314588) ### Brand names (2) - miebo - Miebo ### Other names (22) - Densiron \[(F6H8) - densiron f6h8 - f6h8 - F6H8 - miebo - Miebo - nov 03 - NOV-03 - nov03 - Nov03 - NOV03 - perfluorohexyloctane - Perfluorohexyloctane - Perfluorohexyloctane \[INN\] - Perfluorohexyloctane \[USAN\] - Perfluorohexyloctane \[WHO-DD\] - perfluorohexyloctane inn - Perfluorohexyloctane ophthalmic solution - perfluorohexyloctane usan - perfluorohexyloctane who dd - perfluorohexyloctano - Perfluorohexyloctano ## Identifiers **CAS registry numbers** - 133331-77-8 **ChEMBL ID** CHEMBL5314588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314588) **InChIKey** WRYIIOKOQSICTB-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314588) **PubChem compound IDs** - 10477896 **RxNorm IDs (RxCUI)** - 2637547 **FDA ingredient codes (UNII)** - 7VYX4ELWQM ## Regulatory information ### United States **Applicant** BAUSCH AND LOMB INC **Approval date** 18 May 2023 **Application number** NDA216675 ### Other regulatory facts **Patents** 6 **Designations** 0 **Earliest recorded loss of exclusivity** 21 Jun 2037 **First in class** Yes **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Drug name stem** perflu- #### Administration routes - topical ### Investigated indications (3) - **Condition** Meibomian Gland Dysfunction **Highest recorded phase** 1 **Subject identifier** D000080343 - **Condition** Retinal Detachment **Highest recorded phase** 2 **Condition identifier** EFO:0005773 **Subject identifier** D012163 - **Condition** Dry Eye Syndromes **Highest recorded phase** 4 **Condition identifier** EFO:1000906 **Subject identifier** D015352 ### Open Targets indications (5) - **Condition identifier** EFO\_0005773 - **Condition identifier** EFO\_1000906 - **Condition identifier** MONDO\_0005464 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0006733 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0700115 **Highest recorded phase** 2 ### Trial references (8) - NCT00403702 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00403702) - NCT03333057 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03333057) - NCT04139798 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04139798) - NCT04140227 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04140227) - NCT04567329 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04567329) - NCT05723770 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05723770) - NCT06309953 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06309953) - NCT06346340 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06346340) ## Dosing **Dose** One drop **Route** Eye drops **How often** Four times daily ### Conditions of use - Contact lenses should be removed prior to and for at least 30 minutes after administration ## Chemical properties **Hydrogen bond acceptors** 0 **Hydrogen bond donors** 0 **Polar surface area** 0 **Calculated partition coefficient (ALogP)** 7.48 **Calculated partition coefficient (XLogP)** 8.7 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 11 **Heavy atoms** 27 **Molecular formula** C14H17F13 **Monoisotopic mass** 432.1122666 **Natural product** No ## National Drug Codes - 24208-377 ## Related records ### Trials (18) - A Multicenter, Open-Label Study to Evaluate Perioperative Treatment of Dry Eye With Miebo® in Subjects Undergoing LASIK - A Single Center, Open-Label Study to Evaluate the Ability of the TearScience™ LipiView™ II Ocular Surface Interferometer and the Keratograph® 5M to Detect Tear Film Stability Utilizing Miebo® - [A Study Evaluating the Safety and Efficacy of a Fixed-Dose Combination for Dry Eye Disease](https://trialight.com/data/trial/a-study-evaluating-the-safety-and-efficacy-of-a-fixed-dose-84bbf443-32bc-41dd-874c-453b479bc646.md) - A Study to Assess the Long-Term Safety of Lifitegrast/Perfluorohexyloctane Fixed-Dose Combination in Subjects With Dry Eye Disease - A Study to Evaluate Concomitant Perfluorohexyloctane Use With Contact Lens Wear - A Study to Evaluate Corneal Endothelial Cell Density (ECD) in Subjects With Dry Eye Disease (DED) Administering Miebo® (Perfluorohexyloctane Ophthalmic Solution) for 12 Months. - A Study to Evaluate Early Treatment Outcomes With Miebo™ in Subjects With Dry Eye Disease - A Study to Evaluate the Effect of Miebo™ on Preoperative Biometry/Keratometry and Postoperative Refractive Accuracy - BL-RX01-TFSTAB-1402 - Comparison High-density Silicone Oils in Retinal Detachment - Effect of NOV03 on Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction (Mojave Study) - Effects of NOV03 on the Tear Film - Evaluation of Miebo (Perfluorohexyloctane) Eyedrops in Habitual Contact Lens Wearers - Long-Term Safety and Tolerability of NOV03 (Perfluorohexyloctane) in Subjects Who Completed Trial NVU-003 (Kalahari Study) - Perfluorohexylcotane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction (Gobi Study) - Perfluorohexyloctane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease (DED) - Perfluorohexyloctane Eye Drops vs. Sodium Hyaluronate for Video Display Terminal-Associated Dry Eye - SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease ### Approved for (1) - [Dry eye syndrome](https://trialight.com/data/condition/dry-eye-syndrome-41ae8541-7903-50ab-9b50-168da1d2f619.md) ### In development for (1) - Retinal detachment Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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