> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/peresolimab-b6de4252-e07c-47e4-b1a0-b81657648fef > Record changed: 2026-10-13 # Peresolimab Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095360) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095360) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095360) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095360) **Drug name** Peresolimab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095360) ### Other names (17) - immunoglobulin g1 anti human programmed cell death protein 1 human monoclonal ly3462817 gamma 1 chain disulfide with human monoclonal ly3462817 kappa chain dimer - IMMUNOGLOBULIN G1, ANTI-(HUMAN PROGRAMMED CELL DEATH PROTEIN 1) (HUMAN MONOCLONAL LY3462817 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL LY3462817 .KAPPA.-CHAIN, DIMER - ly 3462817 - LY-3462817 - ly3462817 - LY3462817 - LY3462817 - IV - LY3462817 (IV) - LY3462817 IV - peresolimab - Peresolimab - peresolimab \[INN\] - PERESOLIMAB \[USAN\] - Peresolimab \[WHO-DD\] - peresolimab inn - peresolimab usan - peresolimab who dd ## Identifiers **CAS registry numbers** - 2411580-63-5 **ChEMBL ID** CHEMBL5095360 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095360) **FDA ingredient codes (UNII)** - DI4N99Q6KK ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-mab ### Investigated indications (2) - **Condition** Psoriasis **Highest recorded phase** 1 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Arthritis, Rheumatoid **Highest recorded phase** 2 **Condition identifier** EFO:0000685 **Subject identifier** D001172 ### Open Targets indications (4) - **Condition identifier** EFO\_0000676 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000685 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005083 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008383 **Highest recorded phase** 2 ### Trial references (2) - NCT04152382 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04152382) - NCT04634253 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04634253) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (5) - **Component** Glycosylation sites (N) **Sequence** 299 $ 299'''' - **Component** Heavy chain **Type** Protein **Sequence** QVQLVQSGAEVKKPGASVKVSCKVSGYSLSKYDMSWVRQAPGKGLEWMGIIYTSGYTDYAQKFQGRVIMTEDTSTDTAYMELSSLRSEDTAVYYCATGNPYYTNGENSWGQGTLVTVSSASTKGPSVEPLAPSSKSTSGGTAALGCLVKDYFPEPVIVSWNSGALTSGVHTEPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVESCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCQASQSPNNLLAWYQQKPGKAPKLLIYGASDLPSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNNYYVGPVSYAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Disulfide bridges **Sequence** 22-95 $ 22''-95'' $ 23'-88' $ 23'''-88''' $ 137'-197' $ 137'''-197''' $ 146-202 $ 146''-202'' $ 222-217' $ 222''-217''' $ 228-228'' $ 231-231'' $ 263-323 $ 263'-323' $ 369-427 $ 369''-427'' - **Component** Glycosylation sites (N) **Sequence** 299 $ 299'' ## Related records ### Trials (6) - A Relative Bioavailability Study of Peresolimab (LY3462817) Formulations in Healthy Participants - A Safety Study of LY3462817 and LY3509754 in Participants With Psoriasis - A Safety Study of LY3462817 in Healthy Japanese and Non-Japanese Participants - A Safety Study of LY3462817 in Healthy Participants - A Study of LY3462817 in Participants With Rheumatoid Arthritis - [A Study of Peresolimab (LY3462817) in Participants With Moderately-to-Severely Active Rheumatoid Arthritis](https://trialight.com/data/trial/a-study-of-peresolimab-ly3462817-in-participants-with-0dbaefe8-15e1-45f3-962f-1647df769ef8.md) ### In development for (2) - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 1 - [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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