> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/pemvidutide-84c00953-821c-44fd-ba06-b55270f15881
> Record changed: 2026-10-13

# Pemvidutide

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095142)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095142)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095142)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095142)

**Drug name**

Pemvidutide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095142)

### Other names (20)

- alt 801
- ALT-801
- md 1373
- MD-1373
- md1373
- MD1373
- pemvidutida
- Pemvidutida
- pemvidutide
- Pemvidutide
- pemvidutide \[INN\]
- PEMVIDUTIDE \[USAN\]
- Pemvidutide \[WHO-DD\]
- pemvidutide inn
- pemvidutide usan
- pemvidutide who dd
- sp 1373
- SP-1373
- sp1373
- SP1373

## Identifiers

**CAS registry numbers**

- 2538014-94-5

**ChEMBL ID**

CHEMBL5095142

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095142)

**FDA ingredient codes (UNII)**

- A35F525WBG

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-tide

### Investigated indications (10)

- **Condition**  
Leukemia, Myeloid, Acute

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000222

**Subject identifier**  
D015470
- **Condition**  
Obesity

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001073

**Subject identifier**  
D009765
- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Melanoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0002617

**Subject identifier**  
D008545
- **Condition**  
Non-alcoholic Fatty Liver Disease

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003095

**Subject identifier**  
D065626
- **Condition**  
Non-alcoholic Fatty Liver Disease

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001249

**Subject identifier**  
D065626
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0001187

**Subject identifier**  
D001749
- **Condition**  
Urethral Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004192

**Subject identifier**  
D014523
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Diabetes Mellitus, Type 2

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0005148

**Subject identifier**  
D003924

### Open Targets indications (30)

- **Condition identifier**  
EFO\_0001073

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001378
- **Condition identifier**  
EFO\_0003095

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0008573

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001249

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0001513

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0025502

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0001187

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002046

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002691

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004986

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005059

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005062

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005086

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005627

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0007027

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0007576

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008903

**Highest recorded phase**  
1

And 5 more, listed on the interactive page.

### Trial references (12)

- NCT00496860  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00496860)
- NCT01029873  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01029873)
- NCT01326871  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01326871)
- NCT01478074  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01478074)
- NCT01625260  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01625260)
- NCT01670994  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01670994)
- NCT04561245  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04561245)
- NCT04972396  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04972396)
- NCT05006885  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05006885)
- NCT05292911  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05292911)
- NCT05134662  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05134662)
- NCT05295875  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295875)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (2)

- **Component**  
Sequence

**Type**  
Protein

**Sequence**  
HXQGTFTSDYSKYLDEKAAKEFIQWLLQT
- **Component**  
Disulfide bridges

**Sequence**  
16-20

## Related records

### Trials (15)

- A Study of ALT-801 in Combination With Cisplatin and Gemcitabine in Muscle Invasive or Metastatic Urothelial Cancer
- A Study of ALT-801 in Patients With Bacillus Calmette-Guerin (BCG) Failure Non-Muscle Invasive Bladder Cancer
- ALT-801 (Pemvidutide) in Healthy Overweight and Obese Volunteers to Study Safety and Tolerability
- ALT-801 in Diabetic and Non-Diabetic Overweight and Obese Subjects With Non-alcoholic Fatty Liver Disease (NAFLD)
- ALT-801 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus (T2DM)
- ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia
- [Efficacy and Safety of ALT-801 in the Treatment of Obesity](https://trialight.com/data/trial/efficacy-and-safety-of-alt-801-in-the-treatment-of-obesity-46700d91-2e78-4178-90a1-7dddd242a39d.md)
- Extension of ALT-801 in Diabetic and Non-Diabetic Overweight and Obese Subjects With (NAFLD)
- IMPACT TRIAL: Efficacy and Safety of Pemvidutide in Subjects With Nonalcoholic Steatohepatitis (NASH)
- Pemvidutide (ALT-801) DDI Study in Healthy Volunteers
- QUILT-2.008: Study of ALT-801 With Cisplatin in Patients With Metastatic Melanoma
- QUILT-3.020: A Study of ALT-801 in Patients With Relapsed or Refractory Multiple Myeloma
- RECLAIM STUDY: Phase 2 Study of the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol Use Disorder (AUD) in Subjects With Obesity or Overweight
- RESTORE TRIAL: Study of the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol-Associated Liver Disease (ALD)
- Safety and Efficacy Study of ALT-801 to Treat Progressive Metastatic Malignancies

### In development for (13)

- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 1
- Acute myeloid leukemia by FAB classification Phase 2
- [Alcoholic liver disease](https://trialight.com/data/condition/alcoholic-liver-disease-76493111-d619-5800-98d4-77d2608dccf0.md) Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- [Metabolic dysfunction-associated steatohepatitis](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatohepatitis-05fad825-0fff-55c9-8746-0cb406b65c65.md) Phase 1
- [Metabolic dysfunction-associated steatotic liver disease](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatotic-liver-disease-beb92cb4-74bc-5e17-96f1-97aeed54ab35.md) Phase 1
- Metastatic melanoma Phase 1
- [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Phase 2
- [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 1
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 1
- Urethra cancer Phase 1
- Urinary bladder cancer Phase 1
- Urinary bladder carcinoma Phase 2

---

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