> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/pemetrexed-disodium-c80fe85f-320e-4817-87cb-0c8bbcbe8967
> Record changed: 2026-10-13

# Pemetrexed disodium

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2360464)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2360464)

First approval year

2004

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2360464)

## Development status

**First approval year**

2004

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2360464)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2360464)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2360464)

**Drug name**

Pemetrexed disodium

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2360464)

**Molecular weight**

471.38

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2360464)

**Structure (SMILES)**

Nc1nc2\[nH\]cc(CCc3ccc(C(=O)N\[C@@H\](CCC(=O)\[O-\])C(=O)\[O-\])cc3)c2c(=O)\[nH\]1.\[Na+\].\[Na+\]

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2360464)

### Brand names (8)

- alimta
- Alimta
- pemetrexed baxter
- Pemetrexed baxter
- pemetrexed lilly
- Pemetrexed lilly
- pemetrexed sandoz
- Pemetrexed sandoz

### Other names (34)

- disodium n p 2 2 amino 4 7 dihydro 4 oxo 1h pyrrolo 2 3 d pyrimidin 5 yl ethyl benzoyl l glutamate
- DISODIUM N-(P-(2-((2-AMINO-4,7-DIHYDRO-4-OXO-1H-PYRROLO(2,3-D)PYRIMIDIN-5-YL)ETHYL)BENZOYL)-L-GLUTAMATE
- l glutamic acid n 4 2 2 amino 4 7 dihydro 4 oxo 1h pyrrolo 2 3 d pyrimidin 5 yl ethyl benzoyl disodium salt
- L-GLUTAMIC ACID, N-(4-(2-(2-AMINO-4,7-DIHYDRO-4-OXO-1H-PYRROLO(2,3-D)PYRIMIDIN-5-YL)ETHYL)BENZOYL)-, DISODIUM SALT
- ly 231514 disodium salt
- LY-231514 DISODIUM SALT
- ly231514 disodium salt
- LY231514 DISODIUM SALT
- pemetrexed baxter 500 mg powder for concentrate for solution for infusion
- pemetrexed disodium
- Pemetrexed disodium
- Pemetrexed Disodium
- PEMETREXED DISODIUM \[ORANGE BOOK\]
- PEMETREXED DISODIUM \[USAN\]
- PEMETREXED DISODIUM \[USP MONOGRAPH\]
- PEMETREXED DISODIUM \[USP-RS\]
- Pemetrexed disodium \[WHO-DD\]
- Pemetrexed disodium for injection
- Pemetrexed Disodium for Injection
- pemetrexed disodium heptahydrate
- Pemetrexed disodium heptahydrate
- Pemetrexed Disodium Heptahydrate
- Pemetrexed Disodium Injection
- pemetrexed disodium orange book
- pemetrexed disodium usan

And 9 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 150399-23-8

**ChEMBL ID**

CHEMBL2360464

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2360464)

**InChIKey**

NYDXNILOWQXUOF-GXKRWWSZSA-L

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2360464)

**RxNorm IDs (RxCUI)**

- 282443

**FDA ingredient codes (UNII)**

- 2PKU919BA9

### PubChem compound IDs (3)

- 101068009
- 135413520
- 136068113

## Regulatory information

### United States

**Applicant**

SANDOZ

**Approval date**

26 May 2022

**Application number**

NDA214657

### Other regulatory facts

**Patents**

1

**Designations**

3

**Earliest recorded loss of exclusivity**

26 Mar 2035

**First in class**

No

**Fast track**

Yes

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

Yes

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

**Drug name stem**

\-trexed

#### Administration routes

- Parenteral

### Mechanisms of action (3)

- **Mechanism**  
Dihydrofolate reductase inhibitor

**Action type**  
Inhibitor

**Target**  
Dihydrofolate reductase

**Protein identifier**  
P00374
- **Mechanism**  
GAR transformylase inhibitor

**Action type**  
Inhibitor

**Target**  
Trifunctional purine biosynthetic protein adenosine-3

**Protein identifier**  
P22102
- **Mechanism**  
Thymidylate synthase inhibitor

**Action type**  
Inhibitor

**Target**  
Thymidylate synthase

**Protein identifier**  
P04818

### Open Targets mechanisms (3)

- **Mechanism**  
Dihydrofolate reductase inhibitor

**Action type**  
Inhibitor

**Target**  
Dihydrofolate reductase
- **Mechanism**  
GAR transformylase inhibitor

**Action type**  
Inhibitor

**Target**  
Trifunctional purine biosynthetic protein adenosine-3
- **Mechanism**  
Thymidylate synthase inhibitor

**Action type**  
Inhibitor

**Target**  
Thymidylate synthase

### Investigated indications (39)

- **Condition**  
Adenocarcinoma, Bronchiolo-Alveolar

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000308

**Subject identifier**  
D002282
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000365

**Subject identifier**  
D015179
- **Condition**  
Adenocarcinoma of Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000571

**Subject identifier**  
D000077192
- **Condition**  
Lymphoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Mesothelioma

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000588

**Subject identifier**  
D008654
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Sarcoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000691

**Subject identifier**  
D012509
- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000708

**Subject identifier**  
D002294
- **Condition**  
Mesothelioma

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000770

**Subject identifier**  
D008654
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Carcinoma, Large Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003050

**Subject identifier**  
D018287
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003860

**Subject identifier**  
D010190
- **Condition**  
Urogenital Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003863

**Subject identifier**  
D014565
- **Condition**  
Head and Neck Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0006859

**Subject identifier**  
D006258
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0008528

**Subject identifier**  
D001749
- **Condition**  
Neoplasm Metastasis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0009708

**Subject identifier**  
D009362
- **Condition**  
Mesothelioma, Malignant

**Highest recorded phase**  
4

**Condition identifier**  
EFO:1000355

**Subject identifier**  
D000086002
- **Condition**  
Thymoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000576

**Subject identifier**  
D013945
- **Condition**  
Thymoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000581

**Subject identifier**  
D013945
- **Condition**  
Salivary Gland Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0000521

**Subject identifier**  
D012468
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001056

**Subject identifier**  
D013274
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0001187

**Subject identifier**  
D001749
- **Condition**  
Peritoneal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0002087

**Subject identifier**  
D010534
- **Condition**  
Fallopian Tube Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0002158

**Subject identifier**  
D005185

And 14 more, listed on the interactive page.

### Open Targets indications (53)

- **Condition identifier**  
EFO\_0000365
- **Condition identifier**  
EFO\_0000588

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000691

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0002618

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003060
- **Condition identifier**  
EFO\_0006859

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0008528

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000576

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000581

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001012

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1001941

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002087

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002447

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002571

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003220

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0003308

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004669

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004986

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005061

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005062

**Highest recorded phase**  
1

And 28 more, listed on the interactive page.

### Reported adverse events (26)

- **Event**  
acute kidney injury

**Reports**  
353

**Reporting signal score**

211.145
- **Event**  
anaemia

**Reports**  
679

**Reporting signal score**

570.386
- **Event**  
bone marrow failure

**Reports**  
143

**Reporting signal score**

168.748
- **Event**  
colitis

**Reports**  
125

**Reporting signal score**

112.486
- **Event**  
decreased appetite

**Reports**  
284

**Reporting signal score**

126.385
- **Event**  
dehydration

**Reports**  
252

**Reporting signal score**

125.46
- **Event**  
disease progression

**Reports**  
345

**Reporting signal score**

327.897
- **Event**  
febrile neutropenia

**Reports**  
318

**Reporting signal score**

342.381
- **Event**  
general physical health deterioration

**Reports**  
241

**Reporting signal score**

206.677
- **Event**  
injection site pain

**Reports**  
2

**Reporting signal score**

110.901
- **Event**  
interstitial lung disease

**Reports**  
208

**Reporting signal score**

207.554
- **Event**  
leukopenia

**Reports**  
208

**Reporting signal score**

173.429
- **Event**  
lung adenocarcinoma

**Reports**  
56

**Reporting signal score**

132.067
- **Event**  
malignant neoplasm progression

**Reports**  
516

**Reporting signal score**

852.899
- **Event**  
mucosal inflammation

**Reports**  
165

**Reporting signal score**

197.14
- **Event**  
myelosuppression

**Reports**  
103

**Reporting signal score**

164.802
- **Event**  
neutropenia

**Reports**  
502

**Reporting signal score**

412.535
- **Event**  
neutrophil count decreased

**Reports**  
173

**Reporting signal score**

169.862
- **Event**  
non-small cell lung cancer

**Reports**  
89

**Reporting signal score**

269.279
- **Event**  
pancytopenia

**Reports**  
410

**Reporting signal score**

600.909
- **Event**  
pleural effusion

**Reports**  
172

**Reporting signal score**

123.011
- **Event**  
pneumonitis

**Reports**  
143

**Reporting signal score**

176.761
- **Event**  
therapy partial responder

**Reports**  
75

**Reporting signal score**

140.711
- **Event**  
thrombocytopenia

**Reports**  
502

**Reporting signal score**

457.892
- **Event**  
tubulointerstitial nephritis

**Reports**  
118

**Reporting signal score**

161.63

And 1 more, listed on the interactive page.

### Trial references (103)

- NCT00003706  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003706)
- NCT00003711  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003711)
- NCT00070473  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00070473)
- NCT00320073  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00320073)
- NCT00390000  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00390000)
- NCT00573690  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00573690)
- NCT01450384  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01450384)
- NCT06116240  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06116240)
- NCT00005636  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00005636)
- NCT00101283  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00101283)
- NCT00227630  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00227630)
- NCT00541073  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00541073)
- NCT01085630  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01085630)
- NCT01105390  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01105390)
- NCT00006007  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00006007)
- NCT00097383  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00097383)
- NCT00022646  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00022646)
- NCT00117962  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00117962)
- NCT00227539  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00227539)
- NCT00227565  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00227565)
- NCT00248495  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00248495)
- NCT00268489  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00268489)
- NCT00280748  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00280748)
- NCT00301808  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00301808)
- NCT00387322  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00387322)

And 78 more, listed on the interactive page.

## Dosing

**Dose**

500 mg/m2

**Route**

Intravenous

**How often**

Every 3 weeks

### Conditions of use

- Administer over 10 minutes

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

6

**Polar surface area**

191.26

**Calculated partition coefficient (ALogP)**

0.67

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

9

**Heavy atoms**

33

**Molecular formula**

C20H19N5Na2O6

**Monoisotopic mass**

471.11307191

**Natural product**

Yes

## National Drug Codes

- 0409-0004
- 0409-0020
- 0409-0021
- 0409-1045
- 0409-2188
- 0409-3532
- 0781-3518
- 0781-3519
- 0781-3520
- 43598-370
- 43598-386
- 43598-387
- 63323-134
- 63323-450
- 63323-621
- 63323-622
- 68001-543
- 68001-544
- 68001-545
- 68001-546
- 70710-1654
- 70710-1655
- 70710-1674
- 70771-1691
- 70771-1692

And 1 more, listed on the interactive page.

## Evidence counts

**Recorded assays**

144

**Active assays**

12

### Active assay types

- Confirmatory

## Related records

### Trials (101)

- A Clinical Trial of LBL-024 Combination Drug in Patients With Advanced Solid Tumours\[Substudy 01(NSCLC)\]
- A Clinical Trial of TQB2450 Injection Combined With AL2846 Capsules in Patients With Advanced Solid Tumors
- A Efficacy and Safety Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy Versus Placebo Combined With Chemotherapy as First-line Treatment in Subjects With Advanced Non-squamous Cell Non-small Cell Lung Cancer
- A Phase IB/II Clinical Study of SHR-9839 for Injection Combined With Other Anti-tumor Therapies in Patients With Advanced Solid Tumors
- A Phase III Study of SHR-A2102 Versus Investigator-selected Therapy in Advanced Urothelial Carcinoma
- A Study Evaluating Furmonertinib Plus Platinum-based Doublet Chemotherapy Versus Osimertinib in Patients With Epidermal Growth Factor Receptor (EGFR) Sensitizing Mutation-Positive Non-squamous Non-Small Cell Lung Cancer (NSCLC) and Brain Metastases
- [A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma and Other Solid Tumors](https://trialight.com/data/trial/a-study-of-bl-b01d1-pd-1-monoclonal-antibody-in-patients-a31786d9-2f63-4447-9e24-4da50d4ad5f7.md)
- A Study of HRS-4642 in Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation
- A Study of MRG002 Versus Investigator's Choice of Chemotherapy in the Treatment of Patients With HER2-positive Unresectable Advanced or Metastatic Urothelial Cancer
- A Study of SHR-1701 Plus Bevacizumab and Chemotherapy in Non-Small-Cell-Lung-Cancer
- A Study of SHR-A2102 Versus Investigator's Choice of Chemotherapy in Patients With Platinum-based Chemotherapy and PD-(L)1 Inhibitor Treatment Failed Recurrent or Metastatic Cervical Cancer
- A Study of TQB2450 Injection Plus Chemotherapy Followed by TQB2450 Plus Anlotinib Versus Tislelizumab Plus Chemotherapy Followed by Tislelizumab in the Treatment of First-line Non-squamous Non-small Cell Lung Cancer(NSCLC).
- Alimta® Plus Cisplatin & Paclitaxel Given Intraperitonelly; First Line Tx Stage III Ovarian Cancer
- AMG 102, Pemetrexed Disodium, and Cisplatin in Treating Patients With Malignant Pleural Mesothelioma
- Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma
- Azacitidine and Entinostat Before Chemotherapy in Treating Patients With Advanced Non-small Cell Lung Cancer
- AZD2171 and Pemetrexed Disodium in Treating Patients With Relapsed Non-Small Cell Lung Cancer
- Bevacizumab or Pemetrexed Disodium Alone or In Combination After Induction Therapy in Treating Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
- Bortezomib and Pemetrexed Disodium in Treating Patients With Advanced Non-Small Cell Lung Cancer or Other Solid Tumors
- Camrelizumab Combined With Apatinib Mesylate or Camrelizumab Alone for First-line Treatment in Subjects With Programmed Death Ligand 1 (PD-L1) Positive Relapsed or Advanced Non-small Cell Lung Cancer (NSCLC)

### Approved for (4)

- [Malignant mesothelioma](https://trialight.com/data/condition/malignant-mesothelioma-5e55096e-7573-5100-9df6-b4fdf036251d.md)
- Malignant pleural mesothelioma
- [Mesothelioma](https://trialight.com/data/condition/mesothelioma-49ad8bc3-59bf-506b-aa1a-b31c5d0f0e9d.md)
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md)

### In development for (33)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 2
- [Colorectal adenocarcinoma](https://trialight.com/data/condition/colorectal-adenocarcinoma-49107d5a-ece1-5f2b-8783-f2077e298ffa.md) Phase 2
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2
- [Endometrial cancer](https://trialight.com/data/condition/endometrial-cancer-4da2a0bc-7943-502b-a698-cc2beccbed8c.md) Phase 2
- Exocrine pancreatic carcinoma Phase 3
- [Fallopian tube cancer](https://trialight.com/data/condition/fallopian-tube-cancer-b95d05ee-41d5-565a-87e1-041170b88760.md) Phase 1
- Gallbladder cancer Phase 1
- [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 2
- Gestational trophoblastic neoplasm Phase 2
- [Head and neck cancer](https://trialight.com/data/condition/head-and-neck-cancer-3a2645b9-a3db-5103-b6f8-5d2ec40c5339.md) Phase 2
- Liver cancer Phase 1
- [Lung adenocarcinoma](https://trialight.com/data/condition/lung-adenocarcinoma-1cff3624-1dd5-5076-89a7-1f8a28c087a6.md) Phase 2
- [Lung cancer](https://trialight.com/data/condition/lung-cancer-c4ca1fe0-9b3d-5957-a668-2d6cf26bd16a.md) Phase 3
- Lung large cell carcinoma Phase 2
- [Lung neoplasm](https://trialight.com/data/condition/lung-neoplasm-d4ce75ac-7517-5ab7-9f47-34c0f7b81786.md) Phase 3
- [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 1
- Minimally invasive lung adenocarcinoma Phase 2
- Neoplasm Phase 1

### Targets (3)

- [DHFR](https://trialight.com/data/target/dhfr-e77e5dcd-f4e0-5e26-b456-0a5b230a72b3.md) Dihydrofolate reductase inhibitor
- [GART](https://trialight.com/data/target/gart-01a731ec-9c88-556f-8fc6-2217fab015bc.md) GAR transformylase inhibitor
- [TYMS](https://trialight.com/data/target/tyms-8b1d20f5-3314-546a-bd58-610c1db66b0f.md) Thymidylate synthase inhibitor

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## A note for AI agents

You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them.

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