> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/pemetrexed-2221859e-676b-4d76-97df-e11f3f9664a1 > Record changed: 2026-10-13 # Pemetrexed Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) First approval year 2004 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) ## Development status **First approval year** 2004 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) **Drug name** Pemetrexed Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) **Molecular weight** 427.42 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) **Structure (SMILES)** Nc1nc2\[nH\]cc(CCc3ccc(C(=O)N\[C@@H\](CCC(=O)O)C(=O)O)cc3)c2c(=O)\[nH\]1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) ### Brand names (4) - alimta - Alimta - pemfexy - Pemfexy ### Other names (30) - adebrelimab pemetrexed carboplatin - ly 231514 - LY-231514 - ly231514 - LY231514 - nsc 698037 - NSC-698037 - pemetrexed - Pemetrexed - PEMETREXED - Pemetrexed (nonsquamous) - Pemetrexed (Pemetrexed Alvogen) - PEMETREXED \[EMA EPAR\] - PEMETREXED \[HSDB\] - pemetrexed \[INN\] - PEMETREXED \[MI\] - PEMETREXED \[ORANGE BOOK\] - PEMETREXED \[VANDF\] - Pemetrexed \[WHO-DD\] - Pemetrexed 500 mg - Pemetrexed 500 MG - pemetrexed ema epar - pemetrexed hsdb - Pemetrexed injection - pemetrexed inn And 5 more, listed on the interactive page. ## Identifiers **ATC classification codes** - L01BA04 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) **CAS registry numbers** - 137281-23-3 **ChEMBL ID** CHEMBL225072 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) **InChIKey** WBXPDJSOTKVWSJ-ZDUSSCGKSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL225072) **PubChem compound IDs** - 135410875 **FDA ingredient codes (UNII)** - 04Q9AIZ7NO ### RxNorm IDs (RxCUI) (2) - 68446 - 2590669 ## Regulatory information ### United States **Applicant** AVYXA HOLDINGS **Approval date** 28 Jun 2024 **Application number** NDA210661 ### European Union **Status** Authorised **Status date** 20 Sept 2004 **Authorisation date** 20 Sept 2004 **Approved indications** Malignant pleural mesothelioma Alimta in combination with cisplatin is indicated for the treatment of chemotherapy-naïve patients with unresectable malignant pleural mesothelioma. Non-small-cell lung cancer Alimta in combination with cisplatin is indicated for the first-line treatment of patients with locally advanced or metastatic non-small-cell lung cancer other than predominantly squamous cell histology. Alimta is indicated as monotherapy for the maintenance treatment of locally advanced or metastatic non-small-cell lung cancer other than predominantly squamous cell histology in patients whose disease has not progressed immediately following platinum-based chemotherapy. Alimta is indicated as monotherapy for the second line treatment of patients with locally advanced or metastatic non-small-cell lung cancer other than predominantly squamous cell histology. **Product number** EMEA/H/C/000564 **Authorisation holder** Eli Lilly Nederland B.V. **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 5 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Carcinoma, Non-Small-Cell Lung - Mesothelioma European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/alimta) ### Other regulatory facts **Patents** 3 **Designations** 0 **Earliest recorded loss of exclusivity** 19 Feb 2036 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** pemetrexed **Type** Synthetic organic **Drug name stem** \-trexed **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral ### Mechanisms of action (5) - **Action** Inhibition **Action type** Inhibitor **Target** dihydrofolate reductase **Gene symbol** DHFR **Protein identifier** P00374 **Median affinity** 8.15 **Affinity units** pKi **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** thymidylate synthetase **Gene symbol** TYMS **Protein identifier** P04818 **Median affinity** 6.96 **Affinity units** pKi - **Mechanism** Dihydrofolate reductase inhibitor **Action type** Inhibitor **Target** Dihydrofolate reductase **Protein identifier** P00374 - **Mechanism** GAR transformylase inhibitor **Action type** Inhibitor **Target** Trifunctional purine biosynthetic protein adenosine-3 **Protein identifier** P22102 - **Mechanism** Thymidylate synthase inhibitor **Action type** Inhibitor **Target** Thymidylate synthase **Protein identifier** P04818 ### Open Targets mechanisms (4) - **Mechanism** Dihydrofolate reductase inhibitor **Action type** Inhibitor **Target** Dihydrofolate reductase - **Mechanism** GAR transformylase inhibitor **Action type** Inhibitor **Target** Trifunctional purine biosynthetic protein adenosine-3 - **Mechanism** Thymidylate synthase inhibitor **Action type** Inhibitor **Target** Thymidylate synthase - **Mechanism** Thymidylate synthase inhibitor **Action type** Inhibitor **Target** Thymidylate synthase ### DrugCentral mechanisms (3) - **Action type** Inhibitor **Gene symbol** DHFR **Protein identifier** P00374 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** TYMS **Protein identifier** P04818 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** GART **Protein identifier** P22102 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (64) - **Condition** Stomach Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000178 **Subject identifier** D013274 - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000181 **Subject identifier** D002294 - **Condition** Adenocarcinoma **Highest recorded phase** 2 **Condition identifier** EFO:0000228 **Subject identifier** D000230 - **Condition** Carcinoma **Highest recorded phase** 3 **Condition identifier** EFO:0000313 **Subject identifier** D002277 - **Condition** Lymphoma, Large B-Cell, Diffuse **Highest recorded phase** 2 **Condition identifier** EFO:0000403 **Subject identifier** D016403 - **Condition** Adenocarcinoma of Lung **Highest recorded phase** 3 **Condition identifier** EFO:0000571 **Subject identifier** D000077192 - **Condition** Lymphoma **Highest recorded phase** 1 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Mesothelioma **Highest recorded phase** 4 **Condition identifier** EFO:0000588 **Subject identifier** D008654 - **Condition** Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Osteosarcoma **Highest recorded phase** 2 **Condition identifier** EFO:0000637 **Subject identifier** D012516 - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000681 **Subject identifier** D002292 - **Condition** Sarcoma **Highest recorded phase** 2 **Condition identifier** EFO:0000691 **Subject identifier** D012509 - **Condition** Small Cell Lung Carcinoma **Highest recorded phase** 3 **Condition identifier** EFO:0000702 **Subject identifier** D055752 - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000708 **Subject identifier** D002294 - **Condition** Mesothelioma **Highest recorded phase** 4 **Condition identifier** EFO:0000770 **Subject identifier** D008654 - **Condition** Ovarian Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0001075 **Subject identifier** D010051 - **Condition** Uterine Cervical Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0001416 **Subject identifier** D002583 - **Condition** Melanoma **Highest recorded phase** 1 **Condition identifier** EFO:0002617 **Subject identifier** D008545 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0002618 **Subject identifier** D010190 - **Condition** Esophageal Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0002916 **Subject identifier** D004938 - **Condition** Medulloblastoma **Highest recorded phase** 2 **Condition identifier** EFO:0002939 **Subject identifier** D008527 - **Condition** Carcinoma, Large Cell **Highest recorded phase** 2 **Condition identifier** EFO:0003050 **Subject identifier** D018287 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 3 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Urogenital Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0003863 **Subject identifier** D014565 - **Condition** Breast Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0003869 **Subject identifier** D001943 And 39 more, listed on the interactive page. ### Open Targets indications (120) - **Condition identifier** EFO\_0000181 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000313 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000571 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000588 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0000637 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000691 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000702 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000770 - **Condition identifier** EFO\_0002618 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003060 - **Condition identifier** EFO\_0003826 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004142 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004252 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005288 **Highest recorded phase** 1 - **Condition identifier** EFO\_0006859 **Highest recorded phase** 2 - **Condition identifier** EFO\_0006861 **Highest recorded phase** 2 - **Condition identifier** EFO\_1000157 **Highest recorded phase** 2 - **Condition identifier** EFO\_1000657 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001012 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001480 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001901 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001927 **Highest recorded phase** 1 - **Condition identifier** HP\_0100526 - **Condition identifier** MONDO\_0000402 **Highest recorded phase** 2 And 95 more, listed on the interactive page. ### Reported adverse events (26) - **Event** acute kidney injury **Reports** 349 **Reporting signal score** 209.696 - **Event** anaemia **Reports** 675 **Reporting signal score** 572.178 - **Event** bone marrow failure **Reports** 143 **Reporting signal score** 170.634 - **Event** colitis **Reports** 124 **Reporting signal score** 112.3 - **Event** decreased appetite **Reports** 281 **Reporting signal score** 125.891 - **Event** dehydration **Reports** 252 **Reporting signal score** 128.141 - **Event** disease progression **Reports** 345 **Reporting signal score** 332.29 - **Event** febrile neutropenia **Reports** 316 **Reporting signal score** 342.618 - **Event** general physical health deterioration **Reports** 239 **Reporting signal score** 206.272 - **Event** injection site pain **Reports** 2 **Reporting signal score** 109.129 - **Event** interstitial lung disease **Reports** 195 **Reporting signal score** 186.405 - **Event** leukopenia **Reports** 208 **Reporting signal score** 175.977 - **Event** lung adenocarcinoma **Reports** 56 **Reporting signal score** 132.879 - **Event** malignant neoplasm progression **Reports** 510 **Reporting signal score** 844.581 - **Event** mucosal inflammation **Reports** 165 **Reporting signal score** 199.323 - **Event** myelosuppression **Reports** 103 **Reporting signal score** 166.231 - **Event** neutropenia **Reports** 502 **Reporting signal score** 418.765 - **Event** neutrophil count decreased **Reports** 169 **Reporting signal score** 164.735 - **Event** non-small cell lung cancer **Reports** 89 **Reporting signal score** 270.596 - **Event** pancytopenia **Reports** 410 **Reporting signal score** 606.617 - **Event** pleural effusion **Reports** 170 **Reporting signal score** 122.019 - **Event** pneumonitis **Reports** 138 **Reporting signal score** 168.065 - **Event** therapy partial responder **Reports** 75 **Reporting signal score** 141.773 - **Event** thrombocytopenia **Reports** 500 **Reporting signal score** 460.735 - **Event** tubulointerstitial nephritis **Reports** 118 **Reporting signal score** 163.228 And 1 more, listed on the interactive page. ### Trial references (452) - NCT00034489 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00034489) - NCT03242616 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03242616) - NCT03396445 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03396445) - NCT00034606 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00034606) - NCT00061451 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00061451) - NCT00061464 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00061464) - NCT00078260 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00078260) - NCT00087711 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00087711) - NCT00095199 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00095199) - NCT00102804 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00102804) - NCT00111839 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00111839) - NCT00179699 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00179699) - NCT00190840 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00190840) - NCT00191191 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00191191) - NCT00191308 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00191308) - NCT00203931 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00203931) - NCT00216203 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00216203) - NCT00251524 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00251524) - NCT00259285 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00259285) - NCT00269152 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00269152) - NCT00290017 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00290017) - NCT00297089 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00297089) - NCT00308750 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00308750) - NCT00321308 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00321308) - NCT00349089 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00349089) And 427 more, listed on the interactive page. ## Dosing **Dose** 500 mg/m2 **Route** Intravenous **How often** Once every 3 weeks ### Conditions of use (2) - Administered over 10 minutes - Dilute with 5% Dextrose in Water, USP or Normal Saline to 100 mL ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 6 **Polar surface area** 191.26 **Calculated partition coefficient (ALogP)** 0.67 **Calculated partition coefficient (XLogP)** 0.2 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 9 **Heavy atoms** 31 **Molecular formula** C20H21N5O6 **Monoisotopic mass** 427.14918341 **Natural product** Yes ## National Drug Codes - 83831-111 - 83831-112 - 83831-131 - 83831-132 ## Evidence counts **Recorded assays** 823 **Active assays** 273 ### Active assay types (2) - Confirmatory - Other ## Pharmacologic actions - Antineoplastic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000970.html) - Enzyme Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D004791.html) - Folic Acid Antagonists Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D005493.html) - Nucleic Acid Synthesis Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D019384.html) ## Biological measurements ### Observed measurements #### Distribution coefficient (LogD) **Median** \-1.93 **Mean** \-1.93 **Minimum** \-1.93 **Maximum** \-1.93 **Unit** unitless **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - LogD ## Related records ### Trials (974) - (Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations - (HARMONY) Study of BLU-701 in EGFR-mutant NSCLC - A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma - A Clinical Study of Bemcentinib With Standard of Care Chemoimmunotherapy in Untreated Advanced/Metastatic Non-small Cell Lung Cancer Patients With a Mutation in the STK11 Gene - A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007) - A Clinical Study on the Safety and Efficacy of Debio 0932 in Combination With Standard of Care in Patients With Non-small Cell Lung Cancer \[NSCLC\] - A Clinical Study to Evaluate the Safety and Tolerability of AWT020 in Patients With Advanced Malignancies - A Comparison of Two Doses of Pemetrexed in Patients Who Have Lung Cancer - A Drug Interaction Study to Assess the Effect of LY2603618 on the Metabolic Pathway of Desipramine - A First-in-Human Study of CAN04 in Patients With Solid Malignant Tumors - [A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Non-Squamous NSCLC](https://trialight.com/data/trial/a-global-phase-iii-study-of-rilvegostomig-or-pembrolizumab-2214dc53-fd67-4cf8-80fd-2e328685ed0a.md) - A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer. - A Multi-cohort Study of Efbemalenograstim Alfa Injection for Preventing ANC Reduction in Solid Tumor Patients Post Immune-chemotherapy. - A Multicenter Exploratory Clinical Study of Iruplaltinib Combined With Pemetrexed as Neoadjuvant Therapy for Resectable ALK-Positive Non-Squamous Non-Small Cell Lung Cancer - A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC) - A Personal Cancer Vaccine (NEO-PV-01) With Pembrolizumab and Chemotherapy for Patients With Lung Cancer - A Phase 1 Study in Patients With Solid Tumors - A Phase 1/2 Study Evaluating ABT-751 in Combination With Alimta in Advanced Non-Small Cell Lung Cancer - A Phase 1/2 Study of BA3071 in Patients With Solid Tumors - A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors ### Approved for (5) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Malignant peritoneal mesothelioma - Malignant pleural mesothelioma - [Mesothelioma](https://trialight.com/data/condition/mesothelioma-49ad8bc3-59bf-506b-aa1a-b31c5d0f0e9d.md) - Neoplasm ### In development for (57) - [Adenocarcinoma](https://trialight.com/data/condition/adenocarcinoma-b5c321d1-7c49-5bf9-abd0-dfa99dbd5f29.md) Phase 2 - [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 2 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2 - [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 2 - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) Phase 3 - Carcinoma of esophagus Phase 2 - [Cervical adenocarcinoma](https://trialight.com/data/condition/cervical-adenocarcinoma-013a4346-286c-5c50-bd25-66fde59ac6a0.md) Phase 3 - [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 3 - Chordoma Phase 1 - [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2 - [Colorectal neoplasm](https://trialight.com/data/condition/colorectal-neoplasm-31f0a633-3abe-5df4-9d3a-9292c6541f1d.md) Phase 2 - [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 2 - [Endometrial cancer](https://trialight.com/data/condition/endometrial-cancer-4da2a0bc-7943-502b-a698-cc2beccbed8c.md) Phase 1 - [Esophageal cancer](https://trialight.com/data/condition/esophageal-cancer-a3b5271c-e6d4-537b-8dfd-9391c60e2af2.md) Phase 2 - Exocrine pancreatic carcinoma Phase 2 - [Fallopian tube cancer](https://trialight.com/data/condition/fallopian-tube-cancer-b95d05ee-41d5-565a-87e1-041170b88760.md) Phase 2 - Fallopian tube carcinoma Phase 2 - [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 3 - Gastric carcinoma Phase 3 - [Gastric neoplasm](https://trialight.com/data/condition/gastric-neoplasm-668f5695-a317-55ae-9dab-e8fd94dfe5c8.md) Phase 3 ### Targets (3) - [DHFR](https://trialight.com/data/target/dhfr-e77e5dcd-f4e0-5e26-b456-0a5b230a72b3.md) Dihydrofolate reductase inhibitor - [GART](https://trialight.com/data/target/gart-01a731ec-9c88-556f-8fc6-2217fab015bc.md) GAR transformylase inhibitor - [TYMS](https://trialight.com/data/target/tyms-8b1d20f5-3314-546a-bd58-610c1db66b0f.md) Thymidylate synthase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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