> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/pelacarsen-sodium-24b0b702-cc3c-464c-a8d6-28bf8b369e0b > Record changed: 2026-10-13 # Pelacarsen sodium Highest phase reached Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298203) Drug type Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298203) ## Development status **Listing at source** Listed **Highest phase reached** Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298203) ## Names and chemistry **Drug type** Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298203) **Drug name** Pelacarsen sodium Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298203) ### Other names (14) - akcea apo a lrx salt - AKCEA-APO(a)-LRx salt - isis 681257 - isis 681257 galnac3 conjugated aso targeting human lipoprotein a - isis 681257 salt - ISIS 681257 salt - isis 681257 sodium - ISIS-681257 - ISIS-681257 (GALNAC3--CONJUGATED ASO TARGETING HUMAN LIPOPROTEIN (A) ) - ISIS-681257 SODIUM - pelacarsen sodium - Pelacarsen sodium - PELACARSEN SODIUM \[USAN\] - pelacarsen sodium usan ## Identifiers **CAS registry numbers** - 2172851-58-8 **ChEMBL ID** CHEMBL4298203 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298203) **FDA ingredient codes (UNII)** - D1J27662O8 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-rsen ### Investigated indications - **Condition** Coronary Artery Disease **Highest recorded phase** 1 **Condition identifier** EFO:0001645 **Subject identifier** D003324 ### Open Targets indications (2) - **Condition identifier** EFO\_0001645 - **Condition identifier** MONDO\_0005010 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences - **Component** Sequence **Type** Nucleic Acid **Sequence** 20Na+ \[(3'-5')R1-U=G-C-U-C-d(C=G=T=T=G=G=T=G=C=T=)U-G-U=U=C\]20- ## Related records ### Trials (15) - [A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis](https://trialight.com/data/trial/a-multicenter-trial-assessing-the-impact-of-lipoprotein-a-51773799-ce02-463c-ae31-aa417295a17d.md) - A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Rate of Weekly Lipoprotein Apheresis Sessions in Patients With Hyperlipoproteinemia(a) and Established Cardiovascular Disease in Germany - A Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Pelacarsen (ISIS 681257) in Healthy Japanese Participants - [An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)](https://trialight.com/data/trial/an-open-label-extension-ole-study-following-completion-of-377637e1-2c3d-44cc-a182-45f5a9dd3202.md) - An Open Label Extension (OLE) Study to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230) - Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Clopidogrel - Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Warfarin - Influence of Pelacarsen on Patients After Myocardial Infarction With High Lp(a) Values (PEMILA) - Lp(a) Lowering Study of Pelacarsen (TQJ230) in Patients in the US With Elevated Lp(a) and Recent ACS (STEMI/NSTEMI) - Lp(a)FRONTIERS PEARL - Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD - Managed Access Programs for TQJ230, Pelacarsen - Pelacarsen Roll-over Extension Program - Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular Disease - Study of ISIS 681257 in Patients With Renal Impairment Compared to Healthy Patients - Study to Assess the Pharmacokinetics of Pelacarsen (TQJ230) in Participants With Mild Hepatic Impairment Compared to Matched Healthy Participants ### In development for (1) - [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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