> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/pegloxenatide-6d7427b0-c0b0-4e02-9bb8-25f2f8b315d7 > Record changed: 2026-10-13 # Pegloxenatide Highest phase reached Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802213) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802213) ## Development status **Listing at source** Listed **Highest phase reached** Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802213) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802213) **Drug name** Pegloxenatide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802213) ### Other names (17) - peg 40 kd loxenatide - peg loxenatide - Peg loxenatide - Peg-40 kd-loxenatide - pegloxenatide - Pegloxenatide - pegloxenatide \[INN\] - pegloxenatide inn - pex 168 - PEX-168 - pex168 - Pex168 - PEX168 - PEX168(100µg) - PEX168(200µg) - poly oxy 1 2 ethanediyl alpha hydro omega methoxy 39 39 diester with l histidyl d alanyl l alpha glutamylglycyl l threonyl l phenylalanyl l threonyl l seryl l alpha aspartyl l leucyl l seryl l lysyl l glutaminyl l norleucyl l alpha glutamyl l alpha glutamyl l alpha glutamyl l alanyl l valyl l arginyl l leucyl l phenylalanyl l isoleucyl l alpha glutamyl l tryptophyl l leucyl l lysyl l glutaminylglycylglycyl l prolyl l seryl l serylglycyl l alanyl l prolyl l prolyl l prolyl s 1 3 2 2s 2 6 bis carboxyamino 1 oxohexyl amino ethyl amino 3 oxopropyl 2 5 dioxo 3 pyrrolidinyl l cysteinamide - POLY(OXY-1,2-ETHANEDIYL), .ALPHA.-HYDRO-.OMEGA.-METHOXY-, 39,39-DIESTER WITH L-HISTIDYL-D-ALANYL-L-.ALPHA.-GLUTAMYLGLYCYL-L-THREONYL-L-PHENYLALANYL-L-THREONYL-L-SERYL-L-.ALPHA.-ASPARTYL-L-LEUCYL-L-SERYL-L-LYSYL-L-GLUTAMINYL-L-NORLEUCYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-ALANYL-L-VALYL-L-ARGINYL-L-LEUCYL-L-PHENYLALANYL-L-ISOLEUCYL-L-.ALPHA.-GLUTAMYL-L-TRYPTOPHYL-L-LEUCYL-L-LYSYL-L-GLUTAMINYLGLYCYLGLYCYL-L-PROLYL-L-SERYL-L-SERYLGLYCYL-L-ALANYL-L-PROLYL-L-PROLYL-L-PROLYL-S-(1-(3-((2-(((2S)-2,6-BIS(CARBOXYAMINO)-1-OXOHEXYL)AMINO)ETHYL)AMINO)-3-OXOPROPYL)-2,5-DIOXO-3-PYRROLIDINYL)-L-CYSTEINAMIDE ## Identifiers **CAS registry numbers** - 2420483-82-3 **ChEMBL ID** CHEMBL4802213 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802213) **FDA ingredient codes (UNII)** - BS678C7JWM ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** peg-; -tide ### Investigated indications - **Condition** Diabetes Mellitus, Type 2 **Highest recorded phase** 1 **Condition identifier** MONDO:0005148 **Subject identifier** D003924 ### Open Targets indications (2) - **Condition identifier** MONDO\_0005148 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0006096 **Highest recorded phase** 2 ### Trial references (4) - NCT01965496 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01965496) - NCT01976858 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01976858) - NCT02447601 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02447601) - NCT02467790 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02467790) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (49) - A Dose-finding Study to Evaluate the Effect of a Contraceptive Vaginal Ring, Releasing Nestorone® and Estradiol, on Cycle Control, Ovulation Inhibition, and Pharmacokinetics in Normal Cycling Women - A Phase I Study of 8-week Continuous Treatment With Polyethylene Glycol Loxenatide in Patients With Type 2 Diabetes - A Phase I Study of Polyethylene Glycol Loxenatide in Patients With Type 2 Diabetes - A Safety and Immune Response Study to Evaluate Varying Doses of an mRNA Vaccine Against Coronavirus Disease 2019 (COVID-19) in Healthy Adults - A Safety and Immunogenicity of Intranasal Nanoemulsion Adjuvanted Recombinant Anthrax Vaccine in Healthy Adults - A Safety and Immunogenicity of Intranasal Nanoemulsion Adjuvanted Recombinant Pandemic Flu Vaccine in Healthy Adults - A Single and Multiple-Dose Study of MK-8521 in Healthy and Obese Males (MK-8521-002) - A Study of the Safety and Immune Response of 2 Doses of a New Shigella Vaccine in Kenyan Adults - A Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644) - A Study to Find the Best Dose of BI 1387446 Alone or in Combination With Ezabenlimab (BI 754091) in Patients With Different Types of Advanced or Metastatic Cancer (Solid Tumors) - AEF0217 in Participants With Down Syndrome - An Exploratory Study to Evaluate the Safety of Brimonidine Intravitreal Implant in Patients With Retinitis Pigmentosa - Beclomethasone Dipropionate HFA in Adult and Adolescent Subjects With Mild to Moderate Persistent Asthma - Clinical Study of the Effectiveness, Tolerability and Safety of the Drug "Anti-spike, Gel, 100 g in Bottles in Package No. 1" Produced by the Republican Unitary Enterprise "Unitekhprom BSU", With a Single Intraperitoneal Use After Surgery in Adult Patients With Acute Phlegmonous Appendicitis - Clinical Trial to Assess Safety and Immunogenicity of a Synthetic Vaccine Against Streptococcus Pyogenes - Dose Escalation Trial to Evaluate Dose Limiting Toxicity/Maximum Tolerated Dose of Microneedle Arrays Containing Doxorubicin (D-MNA) in Basal Cell Carcinoma (BCC) - Dose-finding of PB-119 Administered Subcutaneously Once Weekly Versus Placebo in Subjects With Type 2 Diabetes - DUVAX: A Phase 1 Alzheimer's Vaccine Study Targeting Amyloid-Beta and Tau - Efficacy and Safety of CHF 1535 200/6µg in Not Adequately Controlled Asthmatic Patients - Efficacy and Safety Study of PEX168 in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin ### In development for (1) - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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