> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/patritumab-deruxtecan-4c50b491-6b8e-4e9b-a05d-3ab136f301a9
> Record changed: 2026-10-13

# Patritumab deruxtecan

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594611)

Drug type

Antibody drug conjugate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594611)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594611)

## Names and chemistry

**Drug type**

Antibody drug conjugate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594611)

**Drug name**

Patritumab deruxtecan

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594611)

### Other names (26)

- anti her3 antibody drug conjugate u3 1402
- ANTI-HER3 ANTIBODY-DRUG CONJUGATE U3 1402
- immunoglobulin g1 anti human epidermal growth factor receptor her3 human monoclonal u3 1287 γ1 chain complex with human monoclonal u3 1287 κ chain dimer octakis thioether with n 6 3 mercapto 2 5 dioxo 1 pyrrolidinyl 1 oxohexyl glycylglycyl l phenylalanyl n 2 1s 9s 9 ethyl 5 fluoro 2 3 9 10 13 15 hexahydro 9 hydroxy 4 methyl 10 13 dioxo 1h 12h benzo de pyrano 3 4 6 7 indolizino 1 2 b quinolin 1 yl amino 2 oxoethoxy methyl glycinamide
- immunoglobulin g1 kappa anti homo sapiens erbb3 receptor tyrosine protein kinase erbb 3 her3 homo sapiens monoclonal antibody conjugated to deruxtecan comprising a linker and a camptothecin derivative gamma1 heavy chain homo sapiens 1 447 vh homo sapiens ighv4 34 01 99 0 ighd ighj2 01 100 8 7 11 1 117 homo sapiens ighg1 03 100 g1m3 ng1m1 ch1 r120 214 118 215 hinge 1 15 216 230 ch2 231 340 ch3 e12 356 m14 358 341 445 chs 446 447 123 452 220 220 disulfide with kappa light chain homo sapiens 1 220 v kappa homo sapiens igkv4 1 01 95 0 igkj1 01 100 12 3 9 1 113 homo sapiens igkc 01 100 km3 a45 1 159 v101 197 114 220 dimer 226 226 229 229 bisdisulfide produced in chinese hamster ovary cho cell line glycoform alfa conjugated on an average of 8 cysteinyl to deruxtecan comprising a linker and a camptothecin derivative
- Immunoglobulin G1-kappa, anti-\[Homo sapiens ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3)\], Homo sapiens monoclonal antibody, conjugated to deruxtecan, comprising a linker and a camptothecin derivative; gamma1 heavy chain Homo sapiens (1-447) \[VH (Homo sapiens IGHV4-34\*01 (99.0%) -(IGHD) - IGHJ2\*01 (100%)) \[8.7.11\] (1-117) - Homo sapiens IGHG1\*03 (100%) G1m3, nG1m1 (CH1 R120 (214) (118-215), hinge 1-15 (216-230), CH2 (231-340), CH3 E12 (356), M14 (358) (341-445), CHS (446-447)) (123-452)\], (220-220')-disulfide with kappa light chain Homo sapiens (1'-220') \[V-KAPPA (Homo sapiens IGKV4-1\*01 (95.0%) -IGKJ1\*01 (100%)) \[12.3.9\] (1'-113') - Homo sapiens IGKC\*01 (100%) Km3 A45.1 (159), V101 (197) (114'-220')\]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO) cell line, glycoform alfa; conjugated, on an average of 8 cysteinyl, to deruxtecan, comprising a linker and a camptothecin derivative
- Immunoglobulin G1, anti-(human epidermal growth factor receptor HER3) (human monoclonal U3-1287 γ1-chain), complex with human monoclonal U3-1287 κ-chain, dimer, octakis(thioether) with N-\[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl\]glycylglycyl-L-phenylalanyl-N-\[\[2-\[\[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo\[de\]pyrano\[3′,4′:6,7\]indolizino\[1,2-b\]quinolin-1-yl\]amino\]-2-oxoethoxy\]methyl\]glycinamide
- patritumab deruxtecan
- Patritumab deruxtecan
- Patritumab Deruxtecan
- Patritumab Deruxtecan (Fixed dose)
- Patritumab Deruxtecan (Up-Titration)
- patritumab deruxtecan \[INN\]
- PATRITUMAB DERUXTECAN \[JAN\]
- PATRITUMAB DERUXTECAN \[USAN\]
- Patritumab deruxtecan \[WHO-DD\]
- patritumab deruxtecan inn
- patritumab deruxtecan jan
- patritumab deruxtecan usan
- patritumab deruxtecan who dd
- u3 1402
- U3 1402
- u3 1402a
- U3-1402
- U3-1402A
- u31402

And 1 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- L01FX36

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594611)

**CAS registry numbers**

- 2227102-46-5

**ChEMBL ID**

CHEMBL4594611

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594611)

**FDA ingredient codes (UNII)**

- 3XPI7EG4W8

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

Yes

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

patritumab deruxtecan

**Type**

Antibody

**Drug name stem**

\-mab; -tecan

### Mechanisms of action (3)

- **Mechanism**  
Receptor tyrosine-protein kinase erbB-3 binding agent

**Action type**  
BINDING\_AGENT

**Target**  
Receptor tyrosine-protein kinase erbB-3

**Protein identifier**  
P21860
- **Action**  
Binding

**Action type**  
Binding

**Target**  
erb-b2 receptor tyrosine kinase 3

**Gene symbol**  
ERBB3

**Protein identifier**  
P21860

**Affinity units**  
pKd
- **Mechanism**  
DNA topoisomerase I inhibitor

**Action type**  
Inhibitor

**Target**  
DNA topoisomerase 1

**Protein identifier**  
P11387

### Open Targets mechanisms (2)

- **Mechanism**  
Receptor tyrosine-protein kinase erbB-3 binding agent

**Action type**  
BINDING AGENT

**Target**  
Receptor tyrosine-protein kinase erbB-3
- **Mechanism**  
DNA topoisomerase I inhibitor

**Action type**  
Inhibitor

**Target**  
DNA topoisomerase 1

### Investigated indications (4)

- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000305

**Subject identifier**  
D001943
- **Condition**  
Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943

### Open Targets indications (26)

- **Condition identifier**  
EFO\_0000305
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001480

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003219

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004986

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004992
- **Condition identifier**  
MONDO\_0005028

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005036

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005140

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005192

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005212

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008903

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0010150

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0011962

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0018666

**Highest recorded phase**  
1

And 1 more, listed on the interactive page.

### Trial references (8)

- NCT02980341  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02980341)
- NCT04610528  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04610528)
- NCT04699630  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04699630)
- NCT04965766  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04965766)
- NCT05569811  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05569811)
- NCT06298084  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06298084)
- NCT04619004  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04619004)
- NCT06383884  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06383884)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (4)

- **Component**  
Disulfide bridges

**Sequence**  
22-95 $ 22''-95'' $ 23'-94' $ 23'''-94''' $ 140'-200' $ 140'''-200''' $ 144-200 $ 144''-200'' $ 220-220' $ 220''-220''' $ 226-226'' $ 229-229'' $ 261-321 $ 261''-321'' $ 367-425 $ 367''-425''
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIEMTQSPDSLAVSLGERATINCRSSQSVLYSSSNRNYLAWYQQNPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVETSKNQFSLKLSSVTAADTAVYYCARDKWTWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Glycosylation sites (N)

**Sequence**  
297 $ 297''

## Related records

### Trials (106)

- 26-week Open Study of telmisartan40mg+amlodipine10mg or telmisartan80mg+amlodipine10 mg in Hypertension
- A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)
- [A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)](https://trialight.com/data/trial/a-clinical-study-of-patritumab-deruxtecan-to-treat-breast-1962c52e-34fb-4ad2-b312-330e0edf6f40.md)
- A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) Cholesterol
- A Phase Ib/II Study of SYS6090 Combination Therapy in Advanced Colorectal Cancer
- A Phase II, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Neoadjuvant Therapy With Inavolisib Plus Pertuzumab and Trastuzumab as Subcutaneous (PH-FDC SC) and 3-week Cycle Nab-paclitaxel for PIK3CA-mutated, HER2+, eBC
- A Study Assessing a Range of Formulations of the Fixed Dose Combination Product Containing Dutasteride (0.5mg) and Tamsulosin Hydrochloride (0.2mg) to Find a Formulation Which is Bioequivalent to Harnal-D Tablets (Tamsulosin Hydrochloride, 0.2mg) in Healthy Male Subjects From North East Asia
- [A Study in Healthy Male Subjects to Investigate the Comparability of Pharmacokinetics of the Fixed-Dose Combination of Pertuzumab and Trastuzumab Administered Subcutaneously Using a Handheld Syringe or Using the On-Body Delivery System](https://trialight.com/data/trial/a-study-in-healthy-male-subjects-to-investigate-the-5cbf2ca9-365d-4fdb-b6ec-aa6dd12ddb84.md)
- A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain
- A Study of Patritumab Deruxtecan (HER3-DXd) in Combination With Trastuzumab Deruxtecan (T-DXd) in Participants With HR-Positive, HER2-Low or HER2-Ultralow Unresectable or Metastatic Breast Cancer
- A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)
- A Study of U3-1402 (Patritumab Deruxtecan) in Subjects With Metastatic Breast Cancer
- A Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administration in Participants With Early or Locally Advanced/Inflammatory HER2-Positive Breast Cancer
- A Study to Evaluate U3-1402 in Subjects With Advanced or Metastatic Colorectal Cancer
- A Trial to Learn if Fianlimab and Cemiplimab Are Safe and Work Better Than Anti-PD1 Alone in Adult Participants With Resectable Stage 3 or 4 Melanoma
- A Window of Opportunity Study of Patritumab Deruxtecan in Patients With Brain Metastases
- A Window-of-opportunity Study of U3-1402, a HER3-targeting Antibody-drug Conjugate in Operable Breast Cancer According to ERBB3 Expression
- ALTAIR - Alternative Antiretroviral Strategies : a Comparison of Three Initial Regimens
- Assessing the Benefits of Dry Needling for Low Back Pain When Combined With Regular Treatment
- Asthma Research in Children and Adolescents

### In development for (5)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- Breast carcinoma Phase 2
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2
- Neoplasm Phase 3
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2

### Other linked conditions (1)

- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md)

### Targets (2)

- [ERBB3](https://trialight.com/data/target/erbb3-916f416c-8797-5fc1-ae92-02910fca19c6.md) Receptor tyrosine-protein kinase erbB-3 binding agent
- [TOP1](https://trialight.com/data/target/top1-efb273d0-ed4a-5281-9372-90a0abb25f90.md) DNA topoisomerase I inhibitor

---

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