> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/paridiprubart-58fc10af-7812-4b60-a9fa-9a3cd77868d1
> Record changed: 2026-11-04

# Paridiprubart

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095366)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095366)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095366)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095366)

**Drug name**

Paridiprubart

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095366)

### Other names (15)

- eb 05
- EB-05
- eb05
- EB05
- Immunoglobulin G1 \[326-serine,329-phenylalanine,de-448-lysine\], anti-(human Toll-like receptor 4) (human-Mus musculus monoclonal EB05 γ1-chain), disulfide with human-Mus musculus monoclonal EB05 κ-chain, dimer
- immunoglobulin g1 326 serine 329 phenylalanine de 448 lysine anti human toll like receptor 4 human mus musculus monoclonal eb05 γ1 chain disulfide with human mus musculus monoclonal eb05 κ chain dimer
- ni 0101
- Ni-0101
- NI-0101
- paridiprubart
- Paridiprubart
- paridiprubart \[INN\]
- PARIDIPRUBART \[USAN\]
- paridiprubart inn
- paridiprubart usan

## Identifiers

**CAS registry numbers**

- 2641646-59-3

**ChEMBL ID**

CHEMBL5095366

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095366)

**FDA ingredient codes (UNII)**

- 4LH8QAS0LR

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

paridiprubart

**Type**

Antibody

**Drug name stem**

\-bart

### Mechanisms of action

- **Action**  
Binding

**Action type**  
Binding

**Target**  
TLR4

**Gene symbol**  
TLR4

**Protein identifier**  
O00206

**Median affinity**

9.86

**Affinity units**  
pKd

### Investigated indications (6)

- **Condition**  
Cytokine Release Syndrome

**Highest recorded phase**  
1

**Subject identifier**  
D000080424
- **Condition**  
Arthritis, Rheumatoid

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000685

**Subject identifier**  
D001172
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000694

**Subject identifier**  
D045169
- **Condition**  
Respiratory Distress Syndrome

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1000637

**Subject identifier**  
D012128
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169
- **Condition**  
Inflammation

**Highest recorded phase**  
1

**Condition identifier**  
MP:0001845

**Subject identifier**  
D007249

### Open Targets indications (9)

- **Condition identifier**  
EFO\_0000685

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000694
- **Condition identifier**  
EFO\_1000637
- **Condition identifier**  
MONDO\_0005147

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0006502

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008383

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0100096
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
2
- **Condition identifier**  
MP\_0001845

### Trial references (2)

- NCT03241108  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03241108)
- NCT04401475  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04401475)

## Chemical properties

**Prodrug**

No

**Inorganic**

No

**Natural product**

No

### Sequences (4)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QVQLQESGPGLVKPSDTLSLTCAVSGYSITGGYSWHWIRQPPGKGLEWMGYIHYSGYTDFNPSLKTRITISRDTSKNQFSLKLSSVTAVDTAVYYCARKDPSDAFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSSKAFPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
EIVLTQSPDFQSVTPKEKVTITCRASQSISDHLHWYQQKPDQSPKLLIKYASHAISGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQGHSFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGSSPVTKSFNRGEC
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 145-201 $ 145''-201'' $ 221-214' $ 221''-214''' $ 227-227'' $ 230-230'' $ 262-322 $ 262''-322'' $ 368-426 $ 368''-426''
- **Component**  
Glycosylation sites (N)

**Sequence**  
298 $ 298''

## Related records

### Trials (3)

- [JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)](https://trialight.com/data/trial/just-breathe-breathing-life-into-innovative-therapies-for-b9153690-ceb2-4470-888a-92b70ddd73e7.md)
- JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart
- Study of an Anti-TLR4 mAb in Rheumatoid Arthritis

### In development for (6)

- Acute respiratory distress syndrome Phase 1
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2
- Cytokine release syndrome Phase 1
- [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) Phase 2
- [Severe acute respiratory syndrome](https://trialight.com/data/condition/severe-acute-respiratory-syndrome-7654d02a-f750-52a0-bec2-afe3b4b3c224.md) Phase 2
- [Type 1 diabetes mellitus](https://trialight.com/data/condition/type-1-diabetes-mellitus-c22c640e-5db9-525c-8e4b-8da31250a7a3.md) Phase 1

### Targets (1)

- [TLR4](https://trialight.com/data/target/tlr4-661eba21-4c38-5c0b-8deb-f67b52ab14b6.md)

---

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