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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/pamvatamig-a5df2d74-d3e2-4073-9237-22262c600757 > Record changed: 2026-10-13 # Pamvatamig Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314862) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314862) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314862) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314862) **Drug name** Pamvatamig Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314862) ### Other names (17) - gamma1 heavy chain anti met homo sapiens 1 452 vh homo sapiens ighv7 4 1 02 95 9 ighd ighj5 02 100 cdr imgt 8 8 16 26 33 51 58 97 112 1 123 homo sapiens ighg1 03 g1m3 ng1m1ch1 r120 e12 m14 g1v72 ch3 d7 e24 ch1 r120 220 124 221 hinge 1 15 222 236 ch2 237 346 ch3 e12 362 m14 364 l7 d 357 l24 e 374 347 451 chs k2 del 452 124 452 226 214 disulfide with common kappa light chain homo sapiens 1 214 v kappa homo sapiens igkv1 39 01 100 igkj1 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 gamma1 heavy chain anti egfr homo sapiens 1 451 vh homo sapiens ighv1 18 01 98 0 ighd ighj4 01 100 cdr imgt 8 8 15 26 33 51 58 97 111 1 122 homo sapiens ighg1 03 g1m3 ng1m1 ch1 r120 e12 m14 g1v73 ch3 k7 k22 ch1 r120 219 123 220 hinge 1 15 221 235 ch2 236 345 ch3 e12 361 m14 363 l7 k 356 t22 k 371 346 450 chs k2 del 451 124 452 226 214 disulfide with common kappa light chain homo sapiens 1 214 v kappa homo sapiens igkv1 39 01 100 igkj1 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 232 231 235 234 bisdisulfide produced in a chinese hamster ovary cho - Gamma1 heavy chain anti-MET Homo sapiens (1-452)\[VH (Homo sapiens IGHV7-4-1\*02 (95.9%) -(IGHD) -IGHJ5\*02 (100%), CDR-IMGT \[8.8.16\] (26-33.51-58.97-112)) (1-123)-Homo sapiens IGHG1\*03, G1m3, nG1m1CH1 R120, E12, M14, G1v72 CH3 D7, E24 (CH1 R120(220) (124-221), hinge 1-15 (222-236), CH2 (237-346),CH3 E12 (362), M14 (364), L7>D (357), L24>E (374)(347-451), CHS K2>del (452)) (124-452)\], (226-214')-disulfide with common kappa light chain Homo sapiens (1'-214') \[V-KAPPA (Homo sapiens IGKV1-39\*01(100%) -IGKJ1\*01 (100%), CDR-IMGT \[6.3.9\] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC\*01(100%), Km3 A45.1 (153), V101 (191) (108'-214')\],gamma1 heavy chain anti-EGFR Homo sapiens (1''-451'') \[VH (Homo sapiens IGHV1-18\*01 (98.0%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[8.8.15\] (26''-33''.51''-58''.97''-111'')) (1''-122'')-Homo sapiens IGHG1\*03, G1m3, nG1m1 CH1 R120, E12, M14,G1v73 CH3 K7, K22 (CH1 R120 (219'') (123''-220''),hinge 1-15 (221''-235''), CH2 (236''-345''), CH3 E12(361''), M14 (363''), L7>K (356''), T22>K (371'') (346''-450''), CHS K2>del (451'')) (124''-452'')\], (226''-214''')-disulfide with common kappa light chain Homo sapiens (1'''-214''') \[V-KAPPA (Homo sapiens IGKV1-39\*01(100%) -IGKJ1\*01 (100%), CDR-IMGT \[6.3.9\] (27'''-32'''.50'''-52'''.89'''-97''')) (1'''-107''') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153'''), V101 (191''')(108'''-214''')\], dimer (232-231'':235-234'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) - Immunoglobulin G1 \[357-aspartic acid,374-glutamic acid,de-C-terminal-lysine\], anti-(human hepatocyte growth factor receptor c-Met) (human monoclonal MCLA-129 γ1-chain), disulfide with human monoclonal MCLA-129 κ-chain, (232→231′),(235→234′)-bis(disulfide) with immunoglobulin G1 \[356-lysine,371-lysine,de-C-terminal-lysine\] anti-(human epidermal growth factor receptor) (human monoclonal MCLA-129 γ1-chain) disulfide with human monoclonal MCLA-129 κ-chain - immunoglobulin g1 357 aspartic acid 374 glutamic acid de c terminal lysine anti human hepatocyte growth factor receptor c met human monoclonal mcla 129 γ1 chain disulfide with human monoclonal mcla 129 κ chain 232 231 235 234 bis disulfide with immunoglobulin g1 356 lysine 371 lysine de c terminal lysine anti human epidermal growth factor receptor human monoclonal mcla 129 γ1 chain disulfide with human monoclonal mcla 129 κ chain - immunoglobulin g1 kappa anti homo sapiens met met proto oncogene hepatocyte growth factor hgf receptor hgfr scatter factor sf receptor hgf sf receptor receptor tyrosine protein kinase c met papillary renal cell carcinoma 2 rccp2 and anti homo sapiens egfr epidermal growth factor receptor receptor tyrosine protein kinase erbb 1 erbb1 her1 her 1 erbb homo sapiens monoclonal antibody bispecific - Immunoglobulin G1-kappa, anti-\[Homo sapiens MET (met proto-oncogene, hepatocyte growth factor (HGF) receptor, HGFR, scatter factor (SF) receptor, HGF/SF receptor, receptor tyrosine-protein kinase c-met, papillary renal cell carcinoma 2, RCCP2)\] and anti-\[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)\], Homo sapiens monoclonal antibody, bispecific - mcla 129 - MCLA 129 \[WHO-DD\] - mcla 129 who dd - Mcla-129 - MCLA-129 - pamvatamig - Pamvatamig - pamvatamig \[INN\] - PAMVATAMIG \[USAN\] - pamvatamig inn - pamvatamig usan ## Identifiers **CAS registry numbers** - 2750004-05-6 **ChEMBL ID** CHEMBL5314862 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314862) **FDA ingredient codes (UNII)** - X3U67W8G5W ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-mig ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (7) - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0003060 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005580 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0010150 **Highest recorded phase** 1 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (5) - **Component** Glycosylation sites (N) **Sequence** 303 $ 302'' - **Component** Heavy chain: anti-MET (H) **Type** Protein **Sequence** QVQLVQSGSELKKPGASVKVSCKASGYTFTTYSMNWVRQAPGQGLEWMGWINTYTGDPTYAQGFTGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARETYFYDRGGYPFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTDPPSREEMTKNQVSLTCEVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG - **Component** Heavy chain: anti-EGFR (H'') **Type** Protein **Sequence** QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISAYNANTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCAKDRHWHWWLDAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTKPPSREEMTKNQVSLKCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 149''-205'' $ 150-206 $ 225''-214''' $ 226-214' $ 232-231'' $ 235-234'' $ 266''-326'' $ 267-327 $ 372''-430'' $ 373-431 ## Related records ### Trials (5) - Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination - [Study of MCLA-129 Combined With Befotertinib in the Treatment of Advanced Non-small Cell Lung Cancer With EGFR Sensitive Mutation](https://trialight.com/data/trial/study-of-mcla-129-combined-with-befotertinib-in-the-9e66c214-4897-447a-83df-219b6a614fca.md) - Study of MCLA-129 in Combination With Ensartinib in Patients With Advanced Solid Tumors. - Study of MCLA-129 in the Treatment of Advanced Non-small Cell Lung Cancer with AGA and MET Amplification. - Study of MCLA-129, a Human Bispecific EGFR and cMet Antibody, in Patients With Advanced NSCLC and Other Solid Tumors ### In development for (2) - Neoplasm Phase 2 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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