> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/palbociclib-2686787c-5f11-4b65-9a5b-549fcd2af644 > Record changed: 2026-10-13 # Palbociclib Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) First approval year 2015 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) ## Development status **First approval year** 2015 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) **Drug name** Palbociclib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) **Molecular weight** 447.54 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) **Structure (SMILES)** CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) ### Brand names (2) - ibrance - Ibrance ### Other names (52) - 100mg palbociclib - 6 acetyl 8 cyclopentyl 5 methyl 2 5 1 piperazinyl 2 pyridinyl amino pyrido 2 3 d pyrimidin 7 8h one - 6-Acetyl-8-cyclopentyl-5-methyl-2-\[\[5-(1-piperazinyl)-2-pyridinyl\]amino\]pyrido\[2,3-d\]pyrimidin-7(8H)-one - azd9833 with palbociclib - ibrance - Ibrance - IBRANCE - palbociclib - Palbociclib - PALBOCICLIB - Palbociclib \[INN\] - Palbociclib \[JAN\] - Palbociclib \[MI\] - Palbociclib \[ORANGE BOOK\] - Palbociclib \[USAN\] - Palbociclib \[WHO-DD\] - Palbociclib 100mg - Palbociclib 125mg - Palbociclib 200mg - Palbociclib 75 mg Capsule - Palbociclib 75mg - Palbociclib 75mg-125mg - Palbociclib capsules - palbociclib inn - palbociclib isethionate And 27 more, listed on the interactive page. ## Identifiers **ATC classification codes** - L01EF01 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) **CAS registry numbers** - 571190-30-2 **ChEMBL ID** CHEMBL189963 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) **InChIKey** AHJRHEGDXFFMBM-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189963) **PubChem compound IDs** - 5330286 **RxNorm IDs (RxCUI)** - 1601374 **FDA ingredient codes (UNII)** - G9ZF61LE7G ## Regulatory information ### United States **Applicant** PFIZER **Approval date** 3 Feb 2015 **Application number** NDA207103 ### European Union **Status** Authorised **Status date** 9 Nov 2016 **Authorisation date** 9 Nov 2016 **Approved indications** Ibrance is indicated for the treatment of hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative locally advanced or metastatic breast cancer: in combination with an aromatase inhibitor; in combination with fulvestrant in women who have received prior endocrine therapy. In pre- or perimenopausal women, the endocrine therapy should be combined with a luteinizing hormone releasing hormone (LHRH) agonist. **Product number** EMEA/H/C/003853 **Authorisation holder** Pfizer Europe MA EEIG **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 1 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Breast Neoplasms European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/ibrance) ### Other regulatory facts **Patents** 10 **Designations** 5 **Earliest recorded loss of exclusivity** 19 Feb 2037 **First in class** Yes **Fast track** No **Breakthrough designation** Yes **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** Yes **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** palbociclib **Type** Synthetic organic **Drug name stem** \-ciclib **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (6) - **Action** Inhibition **Action type** Inhibitor **Target** cyclin dependent kinase 4 **Gene symbol** CDK4 **Protein identifier** P11802 **Median affinity** 7.36 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** cyclin dependent kinase 6 **Gene symbol** CDK6 **Protein identifier** Q00534 **Median affinity** 7.44 **Affinity units** pIC50 - **Mechanism** CDK6/cyclin D1 inhibitor **Action type** Inhibitor **Target** CDK6/cyclin D1 **Protein identifier** P24385 - **Mechanism** CDK6/cyclin D1 inhibitor **Action type** Inhibitor **Target** CDK6/cyclin D1 **Protein identifier** Q00534 - **Mechanism** Cyclin-dependent kinase 4/cyclin D1 inhibitor **Action type** Inhibitor **Target** Cyclin-dependent kinase 4/cyclin D1 **Protein identifier** P11802 - **Mechanism** Cyclin-dependent kinase 4/cyclin D1 inhibitor **Action type** Inhibitor **Target** Cyclin-dependent kinase 4/cyclin D1 **Protein identifier** P24385 ### Open Targets mechanisms (2) - **Mechanism** CDK6/cyclin D1 inhibitor **Action type** Inhibitor **Target** CDK6/cyclin D1 - **Mechanism** Cyclin-dependent kinase 4/cyclin D1 inhibitor **Action type** Inhibitor **Target** Cyclin-dependent kinase 4/cyclin D1 ### DrugCentral mechanisms (4) - **Action type** Inhibitor **Gene symbol** CDK4 **Protein identifier** P11802 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** CDK6 **Protein identifier** Q00534 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** DYRK1A **Protein identifier** Q13627 **Organism** Homo sapiens **Target development level** Chemical evidence - **Action type** Inhibitor **Gene symbol** RPS6KA1 **Protein identifier** Q15418 **Organism** Homo sapiens **Target development level** Chemical evidence ### Investigated indications (53) - **Condition** Sarcoma, Ewing **Highest recorded phase** 2 **Condition identifier** EFO:0000174 **Subject identifier** D012512 - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 3 **Condition identifier** EFO:0000181 **Subject identifier** D002294 - **Condition** Carcinoma, Hepatocellular **Highest recorded phase** 2 **Condition identifier** EFO:0000182 **Subject identifier** D006528 - **Condition** Precursor Cell Lymphoblastic Leukemia-Lymphoma **Highest recorded phase** 1 **Condition identifier** EFO:0000220 **Subject identifier** D054198 - **Condition** Leukemia, Myeloid, Acute **Highest recorded phase** 1 **Condition identifier** EFO:0000222 **Subject identifier** D015470 - **Condition** Adenocarcinoma **Highest recorded phase** 2 **Condition identifier** EFO:0000228 **Subject identifier** D000230 - **Condition** Breast Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:0000305 **Subject identifier** D001943 - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000349 **Subject identifier** D002292 - **Condition** Carcinoma, Intraductal, Noninfiltrating **Highest recorded phase** 2 **Condition identifier** EFO:0000432 **Subject identifier** D002285 - **Condition** Glioblastoma **Highest recorded phase** 1 **Condition identifier** EFO:0000519 **Subject identifier** D005909 - **Condition** Liposarcoma **Highest recorded phase** 2 **Condition identifier** EFO:0000569 **Subject identifier** D008080 - **Condition** Lymphoma **Highest recorded phase** 2 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Oligodendroglioma **Highest recorded phase** 2 **Condition identifier** EFO:0000630 **Subject identifier** D009837 - **Condition** Oligodendroglioma **Highest recorded phase** 2 **Condition identifier** EFO:0000632 **Subject identifier** D009837 - **Condition** Osteosarcoma **Highest recorded phase** 2 **Condition identifier** EFO:0000637 **Subject identifier** D012516 - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000681 **Subject identifier** D002292 - **Condition** Sarcoma **Highest recorded phase** 3 **Condition identifier** EFO:0000691 **Subject identifier** D012509 - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 3 **Condition identifier** EFO:0000707 **Subject identifier** D002294 - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 3 **Condition identifier** EFO:0000708 **Subject identifier** D002294 - **Condition** Melanoma **Highest recorded phase** 2 **Condition identifier** EFO:0000756 **Subject identifier** D008545 - **Condition** Ovarian Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0001075 **Subject identifier** D010051 - **Condition** Multiple Myeloma **Highest recorded phase** 1 **Condition identifier** EFO:0001378 **Subject identifier** D009101 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0002618 **Subject identifier** D010190 - **Condition** Thymus Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0002626 **Subject identifier** D013953 And 28 more, listed on the interactive page. ### Open Targets indications (126) - **Condition identifier** EFO\_0000174 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000181 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000182 - **Condition identifier** EFO\_0000220 - **Condition identifier** EFO\_0000222 - **Condition identifier** EFO\_0000305 - **Condition identifier** EFO\_0000432 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000574 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0000630 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000632 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000681 - **Condition identifier** EFO\_0000691 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000708 - **Condition identifier** EFO\_0000756 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001378 **Highest recorded phase** 2 - **Condition identifier** EFO\_0002618 **Highest recorded phase** 1 - **Condition identifier** EFO\_0002626 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003060 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003085 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003086 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003869 - **Condition identifier** EFO\_0005922 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005952 **Highest recorded phase** 1 - **Condition identifier** EFO\_0006318 **Highest recorded phase** 1 And 101 more, listed on the interactive page. ### Reported adverse events (25) - **Event** alopecia **Reports** 1,925 **Reporting signal score** 2,918.85 - **Event** blood count abnormal **Reports** 599 **Reporting signal score** 1,225.55 - **Event** bone marrow failure **Reports** 541 **Reporting signal score** 768.66 - **Event** breast cancer metastatic **Reports** 315 **Reporting signal score** 753.145 - **Event** constipation **Reports** 902 **Reporting signal score** 444.547 - **Event** decreased appetite **Reports** 1,065 **Reporting signal score** 674.937 - **Event** diarrhoea **Reports** 1,923 **Reporting signal score** 435.04 - **Event** disease progression **Reports** 1,152 **Reporting signal score** 1,237.73 - **Event** dry skin **Reports** 375 **Reporting signal score** 320.641 - **Event** fatigue **Reports** 4,560 **Reporting signal score** 3,684.64 - **Event** full blood count decreased **Reports** 550 **Reporting signal score** 913.627 - **Event** hot flush **Reports** 561 **Reporting signal score** 648.398 - **Event** leukopenia **Reports** 547 **Reporting signal score** 414.329 - **Event** malignant neoplasm progression **Reports** 541 **Reporting signal score** 409.825 - **Event** metastases to bone **Reports** 270 **Reporting signal score** 406.267 - **Event** nausea **Reports** 2,582 **Reporting signal score** 733.332 - **Event** neoplasm progression **Reports** 2,931 **Reporting signal score** 9,391.03 - **Event** neutropenia **Reports** 2,834 **Reporting signal score** 4,023.63 - **Event** neutrophil count decreased **Reports** 694 **Reporting signal score** 879.545 - **Event** oral pain **Reports** 281 **Reporting signal score** 357.677 - **Event** platelet count decreased **Reports** 694 **Reporting signal score** 376.529 - **Event** red blood cell count decreased **Reports** 469 **Reporting signal score** 674.32 - **Event** stomatitis **Reports** 997 **Reporting signal score** 1,458.64 - **Event** tumour marker increased **Reports** 234 **Reporting signal score** 607.197 - **Event** white blood cell count decreased **Reports** 3,283 **Reporting signal score** 6,267.56 ### Trial references (203) - NCT00141297 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00141297) - NCT00420056 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00420056) - NCT02159755 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02159755) - NCT03478514 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03478514) - NCT01209598 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01209598) - NCT01356628 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01356628) - NCT01522989 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01522989) - NCT02925234 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02925234) - NCT03065387 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03065387) - NCT03239015 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03239015) - NCT04185883 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04185883) - NCT04423185 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04423185) - NCT05178888 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05178888) - NCT05867251 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05867251) - NCT01684215 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01684215) - NCT01740427 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01740427) - NCT02297438 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02297438) - NCT02530424 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02530424) - NCT02690480 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02690480) - NCT03220178 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03220178) - NCT03284723 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03284723) - NCT03304080 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03304080) - NCT03423199 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03423199) - NCT03447132 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03447132) - NCT03900884 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03900884) And 178 more, listed on the interactive page. ## Dosing **Dose** 125 mg **Route** Oral **How often** Once daily, 21 days on followed by 7 days off ### Conditions of use - Take with food ## Chemical properties **Hydrogen bond acceptors** 9 **Hydrogen bond donors** 2 **Polar surface area** 105.04 **Calculated partition coefficient (ALogP)** 2.97 **Calculated partition coefficient (XLogP)** 1.8 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 5 **Heavy atoms** 33 **Molecular formula** C24H29N7O2 **Monoisotopic mass** 447.23827319 **Natural product** Yes ## National Drug Codes - 0069-0187 - 0069-0188 - 0069-0189 - 0069-0284 - 0069-0486 - 0069-0688 - 63539-284 - 63539-486 - 63539-688 ## Evidence counts **Recorded assays** 4,498 **Active assays** 831 ### Active assay types (3) - Confirmatory - Other - Screening ## Pharmacologic actions - Antineoplastic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000970.html) - Protein Kinase Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D047428.html) ## Biological measurements ### Observed measurements #### Oral bioavailability **Median** 46 **Mean** 46 **Minimum** 46 **Maximum** 46 **Unit** % **Assays** 2 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (362) - "Neo-Adjuvant Treatment With Palbociclib: Effect on Ki67 and Apoptosis Before, During and After Treatment " - A Biomarker Study of Palbociclib + Fulvestrant for Second, and Third Line of Postmenopausal Women With hr+/her2- Advanced Breast Cancer - A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer - A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease - A Drug-Drug Interaction Study To Investigate The Potential For Multiple Doses Of Palbociclib (PD-0332991) To Alter The Pharmacokinetics Of Oral Midazolam In Adult Healthy Women of Non-Childbearing Potential. - [A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors](https://trialight.com/data/trial/a-first-in-human-dose-escalation-and-expansion-study-to-e30c8326-67cd-4bf8-80bf-5c8c78451254.md) - A First-in-Human Study of D-0502 Alone and in Combination With Palbociclib in Women With Advanced or Metastatic ER-Positive and HER2-Negative Breast Cancer - A Open Label Study of the Efficacy and Safety of PD0332991 a Selective Inhibitor of the Cyclin Dependent Kinases 4 and 6 in Patients With Recurrent Ovarian Cancer Demonstrating Rb-proficiency and Low p16 Expression - [A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors](https://trialight.com/data/trial/a-phase-1-study-of-bms-986500-as-monotherapy-or-combination-d34969aa-e987-4889-910e-0aea7d91d410.md) - A Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer Patients - A Phase 1 Trial of TST of PD 0332991 Followed by Cytarabine and Mitoxantrone for Adults With Relapsed and Refractory Acute Leukemias and High-Risk Myelodysplasia - A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer - A Phase I Clinical Study on SHR6390 in Healthy Chinese Volunteers - A Phase Ib/II Study to Evaluate Multiple Combination Therapies of FWD1802 in Patients With ER+/HER2- BC - A Phase II Randomized Study Evaluating the Biological and Clinical Effects of the Combination of Palbociclib With Letrozole as Neoadjuvant Therapy in Post-Menopausal Women With Estrogen-Receptor Positive Primary Breast Cancer - A Phase II Study of Androgen Deprivation Therapy With or Without Palbociclib in RB-Positive Metastatic Prostate Cancer - A Phase II Study of Palbociclib for Recurrent or Refractory Advanced Thymic Epithelial Tumor - A Pilot Study To Investigate The Effect Of Concurrent Antacid Administration On The Bioavailability Of Six Experimental Formulations Of Palbociclib - A Randomized Study Comparing the Immune Modulation Effect of Ribociclib, Palbociclib, and Abemaciclib in ER+/HER2- EBC - A Randomized, Open-label, Multi-center Phase IV Study Evaluating Palbociclib Plus Endocrine Treatment Versus a Chemotherapy-based Treatment Strategy in Patients With Hormone Receptor Positive / HER2 Negative Breast Cancer in a Real World Setting (GBG 93 - PADMA Study). ### Approved for (6) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) - Breast carcinoma - [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - [HER2 positive breast carcinoma](https://trialight.com/data/condition/her2-positive-breast-carcinoma-eb8493ec-908e-5435-bf56-0d20c0c9bb88.md) - Neoplasm ### In development for (47) - Acute lymphoblastic leukemia Phase 1 - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 1 - [Adenocarcinoma](https://trialight.com/data/condition/adenocarcinoma-b5c321d1-7c49-5bf9-abd0-dfa99dbd5f29.md) Phase 2 - [Breast disorder](https://trialight.com/data/condition/breast-disorder-c24c48eb-9ec6-54b1-80b7-1e9cec90eba4.md) Phase 1 - Breast ductal adenocarcinoma Phase 1 - Chordoma Phase 2 - [Clear cell renal carcinoma](https://trialight.com/data/condition/clear-cell-renal-carcinoma-789eee25-ec64-5771-9b7d-d19544781b11.md) Phase 2 - Colon carcinoma Phase 2 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2 - [Dedifferentiated liposarcoma](https://trialight.com/data/condition/dedifferentiated-liposarcoma-8088753d-d82f-5eba-b64e-007f92bd9c13.md) Phase 2 - Ductal breast carcinoma in situ Phase 2 - [Endometrial cancer](https://trialight.com/data/condition/endometrial-cancer-4da2a0bc-7943-502b-a698-cc2beccbed8c.md) Phase 2 - [Esophageal squamous cell carcinoma](https://trialight.com/data/condition/esophageal-squamous-cell-carcinoma-c10bd9c9-02f9-5805-8008-b021f4604e7a.md) Phase 2 - Ewing sarcoma Phase 2 - Exocrine pancreatic carcinoma Phase 1 - Glioblastoma Phase 1 - [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 3 - [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) Phase 2 - Hereditary breast ovarian cancer syndrome Phase 1 - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1 ### Other linked conditions (2) - Childhood medulloblastoma - [Schizophrenia](https://trialight.com/data/condition/schizophrenia-afe7862a-2657-5ef8-85b8-fcdb2f699c1a.md) ### Targets (3) - [CCND1](https://trialight.com/data/target/ccnd1-5f6a6270-9aec-5f1d-9fd9-19c16cfaf816.md) CDK6/cyclin D1 inhibitor - [CDK4](https://trialight.com/data/target/cdk4-7911e947-47b0-5d57-b5c3-76425934201f.md) Cyclin-dependent kinase 4/cyclin D1 inhibitor - [CDK6](https://trialight.com/data/target/cdk6-a48645cb-6daf-5fe9-a635-f8d00b55b425.md) CDK6/cyclin D1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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