> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/oxytocin-787cf970-fce1-4bab-b1c9-6d816e9784fb
> Record changed: 2026-10-13

# Oxytocin

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

First approval year

1980

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

## Development status

**First approval year**

1980

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

**Drug name**

Oxytocin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

**Molecular weight**

1,007.21

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

**Structure (SMILES)**

CC\[C@H\](C)\[C@@H\]1NC(=O)\[C@H\](Cc2ccc(O)cc2)NC(=O)\[C@@H\](N)CSSC\[C@@H\](C(=O)N2CCC\[C@H\]2C(=O)N\[C@@H\](CC(C)C)C(=O)NCC(N)=O)NC(=O)\[C@H\](CC(N)=O)NC(=O)\[C@H\](CCC(N)=O)NC1=O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

### Brand names (10)

- orasthin
- Orasthin
- oxytocin
- Oxytocin
- pitocin
- Pitocin
- syntocinon
- Syntocinon
- syntometrine
- Syntometrine

### Other names (96)

- 1 iu intravenous oxytocin
- 1 IU intravenous oxytocin
- 10 units Oxytocin
- 2.5 units Oxytocin
- alpha hypophamine
- alpha hypophamine who ip
- Alpha-hypophamine
- ALPHA-HYPOPHAMINE \[WHO-IP\]
- endopituitrina
- Endopituitrina
- glycinamide l cysteinyl l tyrosyl l isoleucyl l glutaminyl l asparaginyl l cysteinyl l prolyl l leucyl cyclic 1 6 disulfide
- GLYCINAMIDE, L-CYSTEINYL-L-TYROSYL-L-ISOLEUCYL-L-GLUTAMINYL-L-ASPARAGINYL-L-CYSTEINYL-L-PROLYL-L-LEUCYL-, CYCLIC (1->6)-DISULFIDE
- intertocine s
- Intertocine s
- intravenous & intramuscular oxytocin
- intravenous oxytocin
- Intravenous oxytocin
- Intravenous Oxytocin
- Intravenous oxytocin infusion
- Intravenous Syntocinon
- IV Oxytocin
- Oral oxytocin
- Oral Oxytocin
- oxitocina
- Oxitocina

And 71 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- H01BB02

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

**CAS registry numbers**

- 50-56-6

**ChEMBL ID**

CHEMBL395429

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

**InChIKey**

XNOPRXBHLZRZKH-DSZYJQQASA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395429)

**PubChem compound IDs**

- 439302

**FDA ingredient codes (UNII)**

- 1JQS135EYN

### RxNorm IDs (RxCUI) (2)

- 7824
- 1733680

## Regulatory information

### United States

**Applicant**

FRESENIUS KABI USA

**Approval date**

9 Jul 1980

**Application number**

NDA018248

### Other regulatory facts

**Patents**

0

**Designations**

2

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

**Boxed warning**

Yes

## Pharmacology

### Drug classification

**Pharmacology name**

oxytocin

**Type**

Peptide

**Drug name stem**

\-tocin

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Parenteral
- topical

### Mechanisms of action (5)

- **Mechanism**  
Oxytocin receptor agonist

**Action type**  
Agonist

**Target**  
Oxytocin receptor

**Protein identifier**  
P30559
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
V2 receptor

**Gene symbol**  
AVPR2

**Protein identifier**  
P30518

**Affinity units**  
pKi
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
OT receptor

**Gene symbol**  
OXTR

**Protein identifier**  
P30559

**Affinity units**  
pKi

**Primary target**  
Yes
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
V1A receptor

**Gene symbol**  
AVPR1A

**Protein identifier**  
P37288

**Affinity units**  
pKi
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
V1B receptor

**Gene symbol**  
AVPR1B

**Protein identifier**  
P47901

**Affinity units**  
pKi

### Open Targets mechanisms

- **Mechanism**  
Oxytocin receptor agonist

**Action type**  
Agonist

**Target**  
Oxytocin receptor

### DrugCentral mechanisms

- **Action type**  
Agonist

**Gene symbol**  
OXTR

**Protein identifier**  
P30559

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (53)

- **Condition**  
Carcinoma, Intraductal, Noninfiltrating

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000432

**Subject identifier**  
D002285
- **Condition**  
Myocardial Infarction

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000612

**Subject identifier**  
D009203
- **Condition**  
Pre-Eclampsia

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0000668

**Subject identifier**  
D011225
- **Condition**  
Obesity

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001073

**Subject identifier**  
D009765
- **Condition**  
Stress Disorders, Post-Traumatic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001358

**Subject identifier**  
D013313
- **Condition**  
Cocaine-Related Disorders

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002610

**Subject identifier**  
D019970
- **Condition**  
Child Development Disorders, Pervasive

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003756

**Subject identifier**  
D002659
- **Condition**  
Autistic Disorder

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003758

**Subject identifier**  
D001321
- **Condition**  
Pain

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003843

**Subject identifier**  
D010146
- **Condition**  
Sleep Apnea Syndromes

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003877

**Subject identifier**  
D012891
- **Condition**  
Attention Deficit Disorder with Hyperactivity

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0003888

**Subject identifier**  
D001289
- **Condition**  
Substance-Related Disorders

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003890

**Subject identifier**  
D019966
- **Condition**  
Sleep Apnea, Obstructive

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003918

**Subject identifier**  
D020181
- **Condition**  
Obsessive-Compulsive Disorder

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004242

**Subject identifier**  
D009771
- **Condition**  
Mood Disorders

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004247

**Subject identifier**  
D019964
- **Condition**  
Arrhythmias, Cardiac

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0004269

**Subject identifier**  
D001145
- **Condition**  
Weight Gain

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004566

**Subject identifier**  
D015430
- **Condition**  
Osteoarthritis, Knee

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004616

**Subject identifier**  
D020370
- **Condition**  
Sexual Dysfunction, Physiological

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004714

**Subject identifier**  
D012735
- **Condition**  
Substance Withdrawal Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004777

**Subject identifier**  
D013375
- **Condition**  
Feeding and Eating Disorders

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005203

**Subject identifier**  
D001068
- **Condition**  
Psychotic Disorders

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005411

**Subject identifier**  
D011618
- **Condition**  
Opioid-Related Disorders

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005611

**Subject identifier**  
D009293
- **Condition**  
Neuralgia

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005762

**Subject identifier**  
D009437
- **Condition**  
Postpartum Hemorrhage

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0009579

**Subject identifier**  
D006473

And 28 more, listed on the interactive page.

### Open Targets indications (138)

- **Condition identifier**  
EFO\_0000246
- **Condition identifier**  
EFO\_0000612
- **Condition identifier**  
EFO\_0000668
- **Condition identifier**  
EFO\_0001073

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001358

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0002610
- **Condition identifier**  
EFO\_0002950
- **Condition identifier**  
EFO\_0003756
- **Condition identifier**  
EFO\_0003758

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003768
- **Condition identifier**  
EFO\_0003877

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003888
- **Condition identifier**  
EFO\_0003890

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003918

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003925

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003958

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004242

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004247

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004269
- **Condition identifier**  
EFO\_0004566

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004616

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004714

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004777

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005203

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005611

And 113 more, listed on the interactive page.

### Warnings

- **Warning**  
Black Box Warning

### Open Targets warnings

- **Warning**  
Black Box Warning

**Country**  
United States

### Reported adverse events (122)

- **Event**  
activated partial thromboplastin time prolonged

**Reports**  
7

**Reporting signal score**

12.7353
- **Event**  
acute pulmonary oedema

**Reports**  
11

**Reporting signal score**

26.2018
- **Event**  
acute right ventricular failure

**Reports**  
2

**Reporting signal score**

8.77716
- **Event**  
amniotic cavity infection

**Reports**  
6

**Reporting signal score**

22.0258
- **Event**  
amniotic fluid embolus

**Reports**  
3

**Reporting signal score**

22.9285
- **Event**  
anaphylactic reaction

**Reports**  
42

**Reporting signal score**

60.5397
- **Event**  
anaphylactic shock

**Reports**  
12

**Reporting signal score**

13.4733
- **Event**  
anaphylactoid syndrome of pregnancy

**Reports**  
2

**Reporting signal score**

10.4923
- **Event**  
apgar score low

**Reports**  
17

**Reporting signal score**

67.8678
- **Event**  
apnoea

**Reports**  
6

**Reporting signal score**

8.98611
- **Event**  
artificial rupture of membranes

**Reports**  
6

**Reporting signal score**

41.7092
- **Event**  
assisted delivery

**Reports**  
2

**Reporting signal score**

12.2776
- **Event**  
asthenia

**Reports**  
2

**Reporting signal score**

11.1049
- **Event**  
bradycardia

**Reports**  
25

**Reporting signal score**

20.8617
- **Event**  
bradycardia foetal

**Reports**  
25

**Reporting signal score**

120.737
- **Event**  
bradycardia neonatal

**Reports**  
4

**Reporting signal score**

10.6881
- **Event**  
brief psychotic disorder, with postpartum onset

**Reports**  
2

**Reporting signal score**

9.50979
- **Event**  
caesarean section

**Reports**  
68

**Reporting signal score**

226.466
- **Event**  
cardiac arrest

**Reports**  
13

**Reporting signal score**

12.9347
- **Event**  
cardiac output increased

**Reports**  
8

**Reporting signal score**

43.7102
- **Event**  
central venous pressure increased

**Reports**  
2

**Reporting signal score**

8.93654
- **Event**  
cerebral palsy

**Reports**  
4

**Reporting signal score**

14.1561
- **Event**  
cerebrovascular spasm

**Reports**  
3

**Reporting signal score**

13.245
- **Event**  
cervix disorder

**Reports**  
3

**Reporting signal score**

10.2195
- **Event**  
convulsion neonatal

**Reports**  
3

**Reporting signal score**

9.28564

And 97 more, listed on the interactive page.

### Trial references (177)

- NCT00263796  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00263796)
- NCT00490802  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00490802)
- NCT01183221  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01183221)
- NCT01308749  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01308749)
- NCT01624194  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01624194)
- NCT01912378  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01912378)
- NCT03033784  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03033784)
- NCT03183674  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03183674)
- NCT00663039  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00663039)
- NCT00813436  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00813436)
- NCT01012167  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01012167)
- NCT01394471  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01394471)
- NCT01517360  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01517360)
- NCT01568528  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01568528)
- NCT01699997  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01699997)
- NCT01712646  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01712646)
- NCT01987050  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01987050)
- NCT02566356  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02566356)
- NCT02567032  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02567032)
- NCT02568709  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02568709)
- NCT02577575  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02577575)
- NCT03900754  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03900754)
- NCT00776360  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00776360)
- NCT00785395  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00785395)
- NCT00884897  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00884897)

And 152 more, listed on the interactive page.

## Dosing

**Dose**

1-10 drops

**Route**

Sublingual

**How often**

3 times a day or as directed by a health professional

### Conditions of use

- Consult a physician for use in children under 12 years of age

## Chemical properties

**Calculated partition coefficient (XLogP)**

\-2.6

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Heavy atoms**

69

**Molecular formula**

C43H66N12O12S2

**Monoisotopic mass**

1006.43645793

**Natural product**

Yes

## National Drug Codes

- 0143-9742
- 0143-9743
- 42023-116
- 42023-130
- 63323-012
- 65219-021
- 55154-9584

## Evidence counts

**Recorded assays**

374

**Active assays**

103

### Active assay types (2)

- Confirmatory
- Other

## Pharmacologic actions

- Oxytocics  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D010120.html)

## Biological measurements

### Observed measurements

#### Oral bioavailability

**Median**

0.85

**Mean**

0.85

**Minimum**

0.85

**Maximum**

0.85

**Unit**

%

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

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### In development for (47)

- [Alcohol dependence](https://trialight.com/data/condition/alcohol-dependence-d26b3f0d-c0fb-5084-9194-e963df0e9179.md) Phase 3
- Alcohol withdrawal Phase 2
- Anorexia nervosa Early phase 1
- [Anxiety disorder](https://trialight.com/data/condition/anxiety-disorder-d84a28fc-7045-53b8-a1b6-52babcd37d08.md) Phase 2
- Attention deficit-hyperactivity disorder Early phase 1
- Autism Phase 2
- Autism spectrum disorder Phase 3
- Benign muscle neoplasm Phase 3
- Cardiac rhythm disease Early phase 1
- Cocaine dependence Phase 2
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2
- [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) Phase 2
- [Diabetes insipidus](https://trialight.com/data/condition/diabetes-insipidus-eb0e3300-ebb1-5892-a012-f19eda2b45b3.md) Phase 1
- Drug dependence Phase 2
- Ductal breast carcinoma in situ Phase 2
- Dystocia Phase 3
- Eating disorder Phase 2
- Fragile X syndrome Phase 2
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- [Gastroparesis](https://trialight.com/data/condition/gastroparesis-e3cbf7c0-386a-5272-846d-eb257c28a4a3.md) Early phase 1

### Other linked conditions (3)

- [Leiomyoma](https://trialight.com/data/condition/leiomyoma-f84b9cb4-e902-5ed0-bb93-4d36211170f3.md)
- Nicotine dependence
- Type 1 diabetes mellitus

### Targets (1)

- [OXTR](https://trialight.com/data/target/oxtr-0754c97c-91cc-5451-9d2f-ebf7271cf9f7.md) Oxytocin receptor agonist

---

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