> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/oxaliplatin-bd23604a-83f3-4d4c-8330-93f435fc2a0b
> Record changed: 2026-10-13

# Oxaliplatin

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL414804)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL414804)

First approval year

2002

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL414804)

## Development status

**First approval year**

2002

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL414804)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL414804)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL414804)

**Drug name**

Oxaliplatin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL414804)

**Molecular weight**

395.27

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL414804)

**Structure (SMILES)**

C1\[C@H\](\[C@H\](N)CCC1)N.\[O-\]C(=O)C(=O)\[O-\].\[Pt+2\]

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/04ZR38536J)

### Brand names (8)

- eloxatin
- Eloxatin
- oxaliplatin
- Oxaliplatin
- oxaliplatin component of folfox
- Oxaliplatin component of folfox
- oxaliplatin component of xelox
- Oxaliplatin component of xelox

### Other names (76)

- (SP-4-2-(1R-TRANS))-(1,2-CYCLOHEXANEDIAMINE-N,N')(ETHANEDIOATO(2-)-O,O')PLATINUM
- capecitabine oxaliplatin 5 fluorouracil
- Drug: Oxaliplatin
- eloxatin
- folfox component oxaliplatin
- Folfox component oxaliplatin
- jm 83
- JM-83
- l ohp
- L-OHP
- mbp 426 liposomal oxaliplatin
- MBP-426
- MBP-426 (LIPOSOMAL OXALIPLATIN)
- nsc 266046
- NSC-266046
- oxaliplatin
- Oxaliplatin
- OXALIPLATIN
- OXALIPLATIN (205803BIJ)
- Oxaliplatin (Eloxatin)
- Oxaliplatin (Eloxatin®)
- Oxaliplatin (in FOLFOX)
- Oxaliplatin (L-OHP)
- Oxaliplatin (OXAL)
- oxaliplatin (SR96669)

And 51 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- L01XA03

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL414804)

**CAS registry numbers**

- 61825-94-3

**ChEMBL ID**

CHEMBL414804

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL414804)

**InChIKey**

ZROHGHOFXNOHSO-BNTLRKBRSA-L

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/04ZR38536J)

**PubChem compound IDs**

- 9887054

**RxNorm IDs (RxCUI)**

- 32592

**FDA ingredient codes (UNII)**

- 04ZR38536J

## Regulatory information

### United States

**Applicant**

SHANDONG

**Approval date**

15 Jan 2026

**Application number**

ANDA219765

### Other regulatory facts

**Patents**

0

**Designations**

5

**First in class**

No

**Fast track**

Yes

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

Yes

**Orphan exclusivity**

No

**Accelerated approval**

Yes

**Availability**

Prescription only

**Boxed warning**

Yes

## Pharmacology

### Drug classification

**Pharmacology name**

oxaliplatin

**Type**

Synthetic organic

**Drug name stem**

\-platin

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Parenteral

### Mechanisms of action

- **Mechanism**  
DNA inhibitor

**Action type**  
Inhibitor

**Target**  
DNA

### Investigated indications (104)

- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000096

**Subject identifier**  
D008224
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000178

**Subject identifier**  
D013274
- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Hodgkin Disease

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000183

**Subject identifier**  
D006689
- **Condition**  
Myelodysplastic Syndromes

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000198

**Subject identifier**  
D009190
- **Condition**  
Lymphoma, T-Cell, Peripheral

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000211

**Subject identifier**  
D016411
- **Condition**  
Leukemia, Myeloid, Acute

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000222

**Subject identifier**  
D015470
- **Condition**  
Adenocarcinoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000228

**Subject identifier**  
D000230
- **Condition**  
Carcinoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000313

**Subject identifier**  
D002277
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000365

**Subject identifier**  
D015179
- **Condition**  
Melanoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000389

**Subject identifier**  
D008545
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000503

**Subject identifier**  
D013274
- **Condition**  
Neoplasms, Germ Cell and Embryonal

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000514

**Subject identifier**  
D009373
- **Condition**  
Leukemia

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000565

**Subject identifier**  
D007938
- **Condition**  
Lymphoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Mesothelioma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000588

**Subject identifier**  
D008654
- **Condition**  
Neoplasms

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Neuroblastoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000621

**Subject identifier**  
D009447
- **Condition**  
Carcinoma, Renal Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000681

**Subject identifier**  
D002292
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000707

**Subject identifier**  
D002294
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001075

**Subject identifier**  
D010051
- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Melanoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0002617

**Subject identifier**  
D008545

And 79 more, listed on the interactive page.

### Open Targets indications (215)

- **Condition identifier**  
EFO\_0000178

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000182
- **Condition identifier**  
EFO\_0000183

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000228

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000313

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000365

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000403

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000503

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000514

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000574

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000588

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000621

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000638

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000681

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000707

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0002618

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0002916

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003100
- **Condition identifier**  
EFO\_0003859

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003860

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003869

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003891

**Highest recorded phase**  
3

And 190 more, listed on the interactive page.

### Warnings

- **Warning**  
Black Box Warning

**Effect**  
immune system toxicity

### Open Targets warnings

- **Warning**  
Black Box Warning

**Effect**  
immune system toxicity

**Country**  
United States

### Reported adverse events (29)

- **Event**  
bone marrow failure

**Reports**  
430

**Reporting signal score**

484.184
- **Event**  
chills

**Reports**  
706

**Reporting signal score**

403.133
- **Event**  
dermatitis acneiform

**Reports**  
220

**Reporting signal score**

422.649
- **Event**  
diarrhoea

**Reports**  
3,036

**Reporting signal score**  
1,374.3
- **Event**  
disease progression

**Reports**  
1,115

**Reporting signal score**  
1,069.46
- **Event**  
febrile neutropenia

**Reports**  
706

**Reporting signal score**

544.347
- **Event**  
gastrointestinal toxicity

**Reports**  
187

**Reporting signal score**

361.878
- **Event**  
haematotoxicity

**Reports**  
282

**Reporting signal score**

451.318
- **Event**  
headache

**Reports**  
236

**Reporting signal score**

355.199
- **Event**  
laryngospasm

**Reports**  
384

**Reporting signal score**  
1,084.18
- **Event**  
leukopenia

**Reports**  
690

**Reporting signal score**

595.873
- **Event**  
metastases to liver

**Reports**  
274

**Reporting signal score**

395.296
- **Event**  
mucosal inflammation

**Reports**  
586

**Reporting signal score**

754.604
- **Event**  
myelosuppression

**Reports**  
267

**Reporting signal score**

375.837
- **Event**  
nausea

**Reports**  
2,539

**Reporting signal score**

548.354
- **Event**  
neuropathy peripheral

**Reports**  
1,988

**Reporting signal score**  
2,909.96
- **Event**  
neurotoxicity

**Reports**  
765

**Reporting signal score**  
1,464.52
- **Event**  
neutropenia

**Reports**  
1,912

**Reporting signal score**  
1,853.36
- **Event**  
palmar-plantar erythrodysaesthesia syndrome

**Reports**  
778

**Reporting signal score**  
1,338.22
- **Event**  
paraesthesia

**Reports**  
970

**Reporting signal score**

632.409
- **Event**  
peripheral sensory neuropathy

**Reports**  
296

**Reporting signal score**

559.342
- **Event**  
polyneuropathy

**Reports**  
328

**Reporting signal score**

495.963
- **Event**  
portal hypertension

**Reports**  
176

**Reporting signal score**

376.207
- **Event**  
pyrexia

**Reports**  
1,517

**Reporting signal score**

422.968
- **Event**  
skin toxicity

**Reports**  
254

**Reporting signal score**

498.654

And 4 more, listed on the interactive page.

### Trial references (1,331)

- NCT00003260  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003260)
- NCT00003287  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003287)
- NCT00003427  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003427)
- NCT00003594  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003594)
- NCT00004102  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00004102)
- NCT00004187  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00004187)
- NCT00005050  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00005050)
- NCT00006015  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00006015)
- NCT00006115  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00006115)
- NCT00006468  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00006468)
- NCT00006479  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00006479)
- NCT00008060  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00008060)
- NCT00008281  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00008281)
- NCT00012389  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00012389)
- NCT00016198  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00016198)
- NCT00016978  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00016978)
- NCT00017082  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00017082)
- NCT00025142  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00025142)
- NCT00026299  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00026299)
- NCT00034619  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00034619)
- NCT00039208  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00039208)
- NCT00049101  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00049101)
- NCT00055822  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00055822)
- NCT00058474  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00058474)
- NCT00061815  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00061815)

And 1,306 more, listed on the interactive page.

## Dosing

**Dose**

85 mg/m 2

**Route**

Intravenous

**How often**

Every 2 weeks

### Conditions of use

- Administer over 120 minutes in separate bags with leucovorin

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Heavy atoms**

15

**Molecular formula**

C8H12N2O4Pt

**Monoisotopic mass**

397.060151

**Natural product**

No

## National Drug Codes

- 0781-3315
- 0781-3317
- 0781-9315
- 0781-9317
- 16729-332
- 25021-233
- 31722-357
- 31722-358
- 42677-336
- 42677-337
- 43066-014
- 43066-018
- 55150-331
- 55150-332
- 61703-363
- 67457-442
- 67457-469
- 68001-468
- 68083-170
- 68083-171
- 68083-176
- 68083-177
- 68083-314
- 71288-101
- 71288-149

And 15 more, listed on the interactive page.

## Evidence counts

**Recorded assays**

32

**Active assays**

10

### Active assay types

- Screening

## Pharmacologic actions

- Antineoplastic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000970.html)

## Related records

### Trials (1,697)

- (PGA) for Platinum-resistant/Refractory, Paclitaxel-Pretreated Recurrent Ovarian and Peritoneal Carcinoma
- 1stline Study Capecitabine Administered on Continuous Way Plus Oxaliplatin&Bevacizumab Every 2weeks in Metastatic CCR.
- 2 Versus 6 Hour Oxaliplatin Infusions in Patients With Gastrointestinal Cancers
- 2nd-line Treatment of Metastatic Colorectal Cancer
- 5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer
- 5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab
- 5-FU, Leucovorin, Oxaliplatin and Docetaxel (FLOT) Versus Epirubicin, Cisplatin and 5-FU (ECF) in Patients With Locally Advanced, Resectable Gastric Cancer
- A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
- A Clinical Study of SH006 Injection in Combination Therapy Versus Regorafenib in the Treatment of Advanced Hepatocellular Carcinoma
- A Clinical Study of SHR-A1811 Combined With Chemotherapy for Platinum Sensitive Recurrent Ovarian Cancer
- A Clinical Study of Sintilimab Combined With Chemothrapy Versus Chemotherapy as Adjuvant Therapy for Gastric/Gastroesophageal Junction Adenocarcinoma
- A Clinical Study of TQB2930 Injection and Chemotherapy With or Without Bevacizumab in the Treatment of Advanced Colorectal Cancer
- A Clinical Study To Evaluate Camrelizumab (SHR-1210) Plus Capecitabine and Oxaliplatin Followed by Sequential Treatment With Camrelizumab Plus Apatinib Mesylate in Advanced or Metastatic Gastric Cancer (GC) or Gastroesophageal Junction Cancer (GEJ) Without Prior Systemic Therapy
- A Clinical Study to Evaluate the Safety and Tolerability of AWT020 in Patients With Advanced Malignancies
- A Clinical Study to Evaluate the Safety and Tolerability of JS107 in Advanced or Metastatic Solid Tumors
- A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course Radiotherapy Followed by TNT in Locally Advanced Rectal Cancer
- [A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body](https://trialight.com/data/trial/a-clinical-trial-of-a-new-combination-treatment-domvanalimab-855f2af6-2909-4db2-a114-5887eeab4af4.md)
- A Clinical Trial of Docetaxel and Oxaliplatin in Patients With Recurrent or Metastatic Breast Cancer
- A Clinical Trial of Two Adjuvant Chemotherapy Regimens for Postoperative Gastric Cancer
- A Feasibility Study of Chemo-radiotherapy to Treat Operable Oesophageal Cancer

### Approved for (2)

- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md)
- Neoplasm

### In development for (103)

- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 1
- [Adenocarcinoma](https://trialight.com/data/condition/adenocarcinoma-b5c321d1-7c49-5bf9-abd0-dfa99dbd5f29.md) Phase 3
- Adult glioblastoma Phase 1
- [Adult hepatocellular carcinoma](https://trialight.com/data/condition/adult-hepatocellular-carcinoma-c10a1a4b-50f0-572a-8bff-bf597d4b7fae.md) Phase 3
- Adult T-cell leukemia/lymphoma Phase 2
- Anus cancer Phase 2
- Bile duct cancer Phase 2
- Bile duct carcinoma Phase 2
- [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 3
- [Biliary tract neoplasm](https://trialight.com/data/condition/biliary-tract-neoplasm-5b757066-5940-52f7-aa7d-e5aafdc5b54e.md) Phase 3
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 2
- Carcinoid tumor Phase 2
- [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) Phase 3
- Carcinoma of esophagus Phase 3
- Central nervous system germ cell tumor Phase 2
- [Central nervous system neoplasm](https://trialight.com/data/condition/central-nervous-system-neoplasm-bd35c306-06e5-549c-a882-45bdfbcbb7d8.md) Phase 2
- [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 2
- [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 3
- Colon adenocarcinoma Phase 3

---

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