> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/oteracil-6bad6a40-4113-4f92-a2ce-1fd23fc478de > Record changed: 2026-10-13 # Oteracil Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL181932) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL181932) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL181932) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL181932) **Drug name** Oteracil Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL181932) **Molecular weight** 157.08 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL181932) **Structure (SMILES)** O=C(O)c1nc(=O)\[nH\]c(=O)\[nH\]1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL181932) ### Other names (21) - 5 azaorotic acid - 5-azaorotic acid - allantoxanic acid - Allantoxanic acid - gimeracil and oteracil potassium capsule - oteracil - Oteracil - OTERACIL \[EMA EPAR\] - oteracil \[INN\] - Oteracil \[WHO-DD\] - oteracil ema epar - oteracil inn - oteracil who dd - oteracilo - Oteracilo - oxonic acid - Oxonic acid - OXONIC ACID \[MI\] - oxonic acid mi - s triazine 2 4 dione 6 carboxylic acid - S-TRIAZINE-2,4-DIONE-6-CARBOXYLIC ACID ## Identifiers **CAS registry numbers** - 937-13-3 **ChEMBL ID** CHEMBL181932 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL181932) **InChIKey** RYYCJUAHISIHTL-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL181932) **PubChem compound IDs** - 4604 **FDA ingredient codes (UNII)** - 5VT6420TIG ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-racil ### DrugCentral mechanisms - **Action type** Inhibitor **Gene symbol** UMPS **Protein identifier** P11172 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (35) - **Condition** Stomach Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000178 **Subject identifier** D013274 - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000181 **Subject identifier** D002294 - **Condition** Carcinoma, Hepatocellular **Highest recorded phase** 2 **Condition identifier** EFO:0000182 **Subject identifier** D006528 - **Condition** Adenocarcinoma **Highest recorded phase** 3 **Condition identifier** EFO:0000228 **Subject identifier** D000230 - **Condition** Colorectal Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000365 **Subject identifier** D015179 - **Condition** Stomach Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000503 **Subject identifier** D013274 - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Small Cell Lung Carcinoma **Highest recorded phase** 2 **Condition identifier** EFO:0000702 **Subject identifier** D055752 - **Condition** Liver Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0001421 **Subject identifier** D008107 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0002618 **Subject identifier** D010190 - **Condition** Esophageal Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0002916 **Subject identifier** D004938 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 2 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Kidney Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0003086 **Subject identifier** D007674 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0003860 **Subject identifier** D010190 - **Condition** Breast Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0003869 **Subject identifier** D001943 - **Condition** Stomach Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0003897 **Subject identifier** D013274 - **Condition** Colorectal Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0004142 **Subject identifier** D015179 - **Condition** Cholangiocarcinoma **Highest recorded phase** 3 **Condition identifier** EFO:0005221 **Subject identifier** D018281 - **Condition** Esophageal Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0005922 **Subject identifier** D004938 - **Condition** Head and Neck Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0006859 **Subject identifier** D006258 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:1000359 **Subject identifier** D010190 - **Condition** Rectal Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:1000657 **Subject identifier** D012004 - **Condition** Stomach Neoplasms **Highest recorded phase** 3 **Condition identifier** MONDO:0001056 **Subject identifier** D013274 - **Condition** Carcinoma, Neuroendocrine **Highest recorded phase** 2 **Condition identifier** MONDO:0002120 **Subject identifier** D018278 - **Condition** Uterine Cervical Neoplasms **Highest recorded phase** 1 **Condition identifier** MONDO:0002974 **Subject identifier** D002583 And 10 more, listed on the interactive page. ### Open Targets indications (46) - **Condition identifier** EFO\_0000181 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000182 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000365 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000503 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000616 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000702 **Highest recorded phase** 2 - **Condition identifier** EFO\_0002618 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003060 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003086 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003860 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003897 - **Condition identifier** EFO\_0004142 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005221 **Highest recorded phase** 3 - **Condition identifier** EFO\_0005922 **Highest recorded phase** 3 - **Condition identifier** EFO\_0006859 **Highest recorded phase** 3 - **Condition identifier** EFO\_1000359 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002120 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002974 - **Condition identifier** MONDO\_0003060 - **Condition identifier** MONDO\_0003060 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0003219 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0003219 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005008 **Highest recorded phase** 3 And 21 more, listed on the interactive page. ### Reported adverse events (8) - **Event** collateral circulation **Reports** 1 **Reporting signal score** 7.58695 - **Event** decreased appetite **Reports** 5 **Reporting signal score** 11.2788 - **Event** hepatic function abnormal **Reports** 3 **Reporting signal score** 8.87124 - **Event** hepatitis acute **Reports** 2 **Reporting signal score** 8.19425 - **Event** hepatitis b **Reports** 2 **Reporting signal score** 8.55681 - **Event** myositis **Reports** 2 **Reporting signal score** 7.67268 - **Event** portosplenomesenteric venous thrombosis **Reports** 1 **Reporting signal score** 8.28 - **Event** pyogenic granuloma **Reports** 2 **Reporting signal score** 13.2661 ### Trial references (223) - NCT00072787 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00072787) - NCT00088816 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00088816) - NCT00134095 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00134095) - NCT00142350 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00142350) - NCT00150670 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00150670) - NCT00152217 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00152217) - NCT00182611 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00182611) - NCT00195572 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00195572) - NCT00202969 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00202969) - NCT00209638 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00209638) - NCT00209664 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00209664) - NCT00209729 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00209729) - NCT00216034 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00216034) - NCT00278863 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00278863) - NCT00287768 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00287768) - NCT00400179 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00400179) - NCT00503321 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00503321) - NCT00687843 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00687843) - NCT00816543 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00816543) - NCT00915382 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00915382) - NCT00960349 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00960349) - NCT00985556 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00985556) - NCT01283204 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01283204) - NCT01285557 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01285557) - NCT01286766 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01286766) And 198 more, listed on the interactive page. ## Chemical properties **Hydrogen bond acceptors** 4 **Hydrogen bond donors** 3 **Polar surface area** 115.91 **Calculated partition coefficient (ALogP)** \-1.84 **Calculated partition coefficient (XLogP)** \-1 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 1 **Heavy atoms** 11 **Molecular formula** C4H3N3O4 **Monoisotopic mass** 157.01235559 **Natural product** Yes ## Evidence counts **Recorded assays** 7 **Active assays** 0 ## Related records ### Trials (18) - [A LM-302 Combination With Other Anti-Tumor Therapies Phase ll Study](https://trialight.com/data/trial/a-lm-302-combination-with-other-anti-tumor-therapies-phase-f867e7b8-f10d-4281-8491-ff6441459c77.md) - A Phase II Study of Gimatecan (ST1481) in Locally Advanced or Metastatic Pancreatic Cancer - A Phase lb/lI Clinical Study in Advanced or Metastatic Esophageal Squamous Cell Carcinoma - A Study of Intraperitoneal Paclitaxel in Combination With SOX Compared With SOX Alone in Gastric Cancer With Malignant Ascites - CCRT Followed by Tegafur, Gimeracil and Oteracil Potassium in Cervical Cancer - Clinical Study of Endostar Injection Concomitant With SOX Protocols to Treat Advanced Gastric Cancer - DC-CIK In Combination With Chemotherapy ( Gio / Oxaliplatin or Cisplatin ) Versus First-line Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma Randomized Controlled Phase II Clinical Study of Treatment - Diffuse Gastric and Esophagogastric Junction Cancer S-1 Trial - Docetaxel+Oxaliplatin+S-1 (DOS) Regimen as Neoadjuvant Chemotherapy in Advanced Gastric Cancer - Effect and Safety of Huaier Granule Versus SOX Regimen in Gastric Cancer Patients - Endostar Combined With MPFC Adjuvant Treatment of Esophageal Cancer Clinical Trial - Neoadjuvant and Adjuvant Therapy Studies of Sintilimab Combined With Chemotherapy With or Without Ipilimumab N01 in Resectable Gastric/Gastroesophageal Junction Adenocarcinoma - Perioperative Chemotherapy for Potentially Resectable Gastric Cancer - Perioperative Therapy for HER2-negative Hepatoid Adenocarcinoma of Stomach - Phase II Study of TS-1 Therapy and TS-1+PSK Therapy Against Advanced Gastric Carcinoma - Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01) - SOX Versus XELOX as Adjuvant Chemotherapy for Stage III Colorectal Cancer Patients - Tripletrumab Combined With Oxaliplatin and Teggio (SOX) in First-line Treatment of Gastric and Gastroesophageal Junction Adenocarcinoma ### In development for (34) - [Adenocarcinoma](https://trialight.com/data/condition/adenocarcinoma-b5c321d1-7c49-5bf9-abd0-dfa99dbd5f29.md) Phase 3 - [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 3 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2 - [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 2 - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2 - Carcinoma of esophagus Phase 3 - [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 1 - [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 3 - [Colorectal adenocarcinoma](https://trialight.com/data/condition/colorectal-adenocarcinoma-49107d5a-ece1-5f2b-8783-f2077e298ffa.md) Phase 3 - [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 3 - [Colorectal neoplasm](https://trialight.com/data/condition/colorectal-neoplasm-31f0a633-3abe-5df4-9d3a-9292c6541f1d.md) Phase 3 - [Esophageal cancer](https://trialight.com/data/condition/esophageal-cancer-a3b5271c-e6d4-537b-8dfd-9391c60e2af2.md) Phase 3 - [Esophageal squamous cell carcinoma](https://trialight.com/data/condition/esophageal-squamous-cell-carcinoma-c10bd9c9-02f9-5805-8008-b021f4604e7a.md) Phase 3 - Exocrine pancreatic carcinoma Phase 3 - [Gastric adenocarcinoma](https://trialight.com/data/condition/gastric-adenocarcinoma-6bb74a55-7ba6-53e3-a113-22296a84d6ae.md) Phase 3 - [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 3 - Gastric carcinoma Phase 3 - [Gastric neoplasm](https://trialight.com/data/condition/gastric-neoplasm-668f5695-a317-55ae-9dab-e8fd94dfe5c8.md) Phase 3 - [Gastroesophageal junction adenocarcinoma](https://trialight.com/data/condition/gastroesophageal-junction-adenocarcinoma-de7e280e-cbd1-5266-a5dd-dda00261a706.md) Phase 3 - [Head and neck cancer](https://trialight.com/data/condition/head-and-neck-cancer-3a2645b9-a3db-5103-b6f8-5d2ec40c5339.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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