> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/oseltamivir-phosphate-258395ae-7f3d-48b8-9c12-7d46cfeae884 > Record changed: 2026-10-13 # Oseltamivir phosphate Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200340) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200340) First approval year 1999 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200340) ## Development status **First approval year** 1999 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200340) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200340) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200340) **Drug name** Oseltamivir phosphate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200340) **Molecular weight** 410.4 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200340) **Structure (SMILES)** CCOC(=O)C1=C\[C@@H\](OC(CC)CC)\[C@H\](NC(C)=O)\[C@@H\](N)C1.O=P(O)(O)O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200340) ### Brand names (6) - ebilfumin - Ebilfumin - oseltamivir phosphate - Oseltamivir phosphate - tamiflu - Tamiflu ### Other names (47) - (-)-Oseltamivir phosphate - (3R-(3.ALPHA.,4.BETA.,5.ALPHA.))-ETHYL 4-(ACETYLAMINO)-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLATE PHOSPHATE (1:1) - 3r 3 alpha 4 beta 5 alpha ethyl 4 acetylamino 5 amino 3 1 ethylpropoxy 1 cyclohexene 1 carboxylate phosphate 1 1 - agucort - Agucort - Oseltamivir (as phosphate) - oseltamivir as phosphate - oseltamivir phosphate - Oseltamivir phosphate - Oseltamivir phosphate \[EP MONOGRAPH\] - Oseltamivir phosphate \[JAN\] - Oseltamivir phosphate \[MART.\] - Oseltamivir phosphate \[MI\] - Oseltamivir phosphate \[ORANGE BOOK\] - Oseltamivir phosphate \[USAN\] - Oseltamivir phosphate \[USP IMPURITY\] - Oseltamivir phosphate \[USP MONOGRAPH\] - Oseltamivir phosphate \[USP-RS\] - Oseltamivir phosphate \[VANDF\] - Oseltamivir phosphate \[WHO-DD\] - Oseltamivir phosphate \[WHO-IP\] - oseltamivir phosphate ep monograph - oseltamivir phosphate jan - oseltamivir phosphate mart - oseltamivir phosphate mi And 22 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 204255-11-8 **ChEMBL ID** CHEMBL1200340 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200340) **InChIKey** PGZUMBJQJWIWGJ-ONAKXNSWSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200340) **RxNorm IDs (RxCUI)** - 259275 **FDA ingredient codes (UNII)** - 4A3O49NGEZ ### PubChem compound IDs (2) - 78000 - 11154112 ## Regulatory information ### United States **Applicant** ROCHE **Approval date** 27 Oct 1999 **Application number** NDA021087 ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Drug name stem** \-vir #### Administration routes - Oral ### Mechanisms of action (2) - **Mechanism** Neuraminidase inhibitor **Action type** Inhibitor **Target** Neuraminidase **Protein identifier** P03468 - **Mechanism** Neuraminidase inhibitor **Action type** Inhibitor **Target** Neuraminidase **Protein identifier** P03474 ### Open Targets mechanisms - **Mechanism** Neuraminidase inhibitor **Action type** Inhibitor **Target** Neuraminidase ### Investigated indications (3) - **Condition** Virus Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0000763 **Subject identifier** D014777 - **Condition** Kidney Failure, Chronic **Highest recorded phase** 4 **Condition identifier** EFO:0003884 **Subject identifier** D007676 - **Condition** Influenza, Human **Highest recorded phase** 4 **Condition identifier** EFO:0007328 **Subject identifier** D007251 ### Open Targets indications (4) - **Condition identifier** EFO\_0003884 - **Condition identifier** EFO\_0007328 - **Condition identifier** MONDO\_0005300 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005812 **Highest recorded phase** 4 ### Reported adverse events (12) - **Event** abnormal behaviour **Reports** 690 **Reporting signal score** 1,934.97 - **Event** convulsion **Reports** 158 **Reporting signal score** 117.806 - **Event** delirium **Reports** 199 **Reporting signal score** 287.141 - **Event** enterocolitis haemorrhagic **Reports** 43 **Reporting signal score** 116.701 - **Event** fatigue **Reports** 56 **Reporting signal score** 119.781 - **Event** hallucination **Reports** 307 **Reporting signal score** 451.452 - **Event** influenza **Reports** 196 **Reporting signal score** 181.444 - **Event** injection site pain **Reports** 1 **Reporting signal score** 86.5281 - **Event** normal newborn **Reports** 331 **Reporting signal score** 1,233.88 - **Event** pregnancy **Reports** 274 **Reporting signal score** 565.467 - **Event** premature delivery **Reports** 72 **Reporting signal score** 86.0895 - **Event** vomiting **Reports** 442 **Reporting signal score** 122.371 ### Trial references (11) - NCT00803595 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00803595) - NCT00979251 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00979251) - NCT00988325 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00988325) - NCT01053377 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01053377) - NCT01053663 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01053663) - NCT01690637 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01690637) - NCT02232945 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02232945) - NCT02572583 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02572583) - NCT02662426 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02662426) - NCT02989012 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02989012) - NCT02469298 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02469298) ## Dosing **Dose** 75 mg **Route** Oral **How often** Twice daily for 5 days ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 2 **Polar surface area** 90.65 **Calculated partition coefficient (ALogP)** 1.29 **Prodrug** Yes **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 7 **Heavy atoms** 27 **Molecular formula** C16H31N2O8P **Monoisotopic mass** 410.18180295 **Natural product** No ## National Drug Codes - 0004-0800 - 0004-0802 - 0004-0822 - 0093-8180 - 0527-4591 - 0527-4592 - 0527-4593 - 0527-5137 - 27241-139 - 31722-108 - 31722-630 - 31722-631 - 31722-632 - 33342-256 - 33342-257 - 33342-258 - 42291-567 - 42291-664 - 42291-666 - 42385-985 - 42385-986 - 42385-987 - 42677-320 - 42677-321 - 42677-322 And 101 more, listed on the interactive page. ## Evidence counts **Recorded assays** 166 **Active assays** 20 ### Active assay types - Confirmatory ## Pharmacologic actions - Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. - Enzyme Inhibitors Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. ## Biological measurements ### Observed measurements #### Oral bioavailability **Median** 4.3 **Mean** 4.3 **Minimum** 4.3 **Maximum** 4.3 **Unit** % **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (138) - A Bioequivalence Study of Oseltamivir From Oseltamivir 75 mg Caps (Pharmacare PLC, Palestine) and Tamiflu® 75 mg Caps (Hoffmann-La Roche, Switzerland) - A Clinical Study of Treating Influenza With Liugan Shuangjie Heji - A Clinical Trial Comparing Oseltamivir With Placebo And Zanamivir With Control As First Line Treatment For Human Swine Influenza Infection - A Clinical Trial to Investigate the Influence of CES1 Polymorphism on Oseltamivir - A Drug-Drug Interaction Study to Evaluate the Effect of AL-794 on the Pharmacokinetics of Oseltamivir and JNJ-63623872 - A Multicenter Randomized Open-label Study of Oseltamivir Combined With HD-DEX Versus HD-DEX in the Management of ITP - A Multinational Phase III Study of CS-8958 (MARVEL) - A Multiple-Dose Study of Oral Oseltamivir in Participants on Hemodialysis (HD) and Continuous Ambulatory Peritoneal Dialysis (CAPD) - A Pharmacokinetic Study on Co-administration of Tamiflu (Oseltamivir) and Rimantadine in Healthy Volunteers - A Pharmacokinetic/Pharmacodynamic (PK/PD) and Safety Evaluation of Oseltamivir \[Tamiflu\] in the Treatment of Infants 0 to <12 Months of Age With Confirmed Flu Infection - A Pharmacokinetic/Pharmacodynamic Study of Oseltamivir in Immunocompromised Children With Confirmed Influenza Infection - A Pharmacokinetics Study of Favipiravir in Patients With Severe Influenza - A Pharmacokinetics, Pharmacodynamics and Safety Study of Warfarin in Combination With Tamiflu (Oseltamivir) - A Phase 2 Trial Comparing Antiviral Treatments in Early Symptomatic Influenza - A Phase 2a to Evaluate the Safety of MEDI8852 in Adults With Uncomplicated Influenza - A Prospective/Retrospective,Randomized Controlled Clinical Study of Antiviral Therapy in the 2019-nCoV Pneumonia - A Randomised Controlled Trial on the Effect of Post-exposure Oseltamivir Prophylaxis on Influenza Transmission in Nursing Homes - A Randomized,Open,Controlled Clinical Study to Evaluate the Efficacy of ASC09F and Ritonavir for 2019-nCoV Pneumonia - A Single Dose Study of Tamiflu in Volunteers in Dialysis And in Volunteers With Reduced Creatinine Clearance - A Study of Intravenous Oseltamivir \[Tamiflu\] in Infants With Influenza ### Approved for (2) - [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) - [Influenza](https://trialight.com/data/condition/influenza-ea12369b-7ed6-5f6b-94fe-eb0e56c24def.md) ### In development for (1) - [Viral infectious disease](https://trialight.com/data/condition/viral-infectious-disease-43db42a3-adad-5b9d-b74c-f17df0674c21.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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