> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/orn-0829-hydrate-92f99085-a773-43bb-b77b-07a441e66c94 > Record changed: 2026-10-13 # Orn-0829 hydrate Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650522) Drug type Small molecule Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/O67SLE6VA3) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650522) ## Names and chemistry **Drug type** Small molecule Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/O67SLE6VA3) **Drug name** Orn-0829 hydrate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650522) **Structure (SMILES)** C(=O)(c1c(ccc(c1)C)-n2nccn2)N3\[C@H\](Cn4nc(cc4)-c5ccc(cn5)F)OCCC3.O.C(=O)(c1c(ccc(c1)C)-n2nccn2)N3\[C@H\](Cn4nc(cc4)-c5ccc(cn5)F)OCCC3.C(=O)(c1c(ccc(c1)C)-n2nccn2)N3\[C@H\](Cn4nc(cc4)-c5ccc(cn5)F)OCCC3.C(=O)(c1c(ccc(c1)C)-n2nccn2)N3\[C@H\](Cn4nc(cc4)-c5ccc(cn5)F)OCCC3 Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/O67SLE6VA3) ### Other names (11) - orn 0829 hydrate - Orn-0829 hydrate - ORN-0829 HYDRATE - orn0829 hydrate - ORN0829 HYDRATE - ts 142 - Ts-142 - TS-142 - TS-142 10 mg - TS-142 5 mg - TS-142, 10 mg ## Identifiers **CAS registry numbers** - 2265899-50-9 **ChEMBL ID** CHEMBL4650522 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650522) **InChIKey** VFOCOQRYYZPTLV-RUCMDRKWSA-N Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/O67SLE6VA3) **PubChem compound IDs** - 154572855 **FDA ingredient codes (UNII)** - O67SLE6VA3 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Mechanisms of action (2) - **Mechanism** Orexin receptor antagonist **Action type** Antagonist **Target** Orexin receptor **Protein identifier** O43613 - **Mechanism** Orexin receptor antagonist **Action type** Antagonist **Target** Orexin receptor **Protein identifier** O43614 ### Open Targets mechanisms - **Mechanism** Orexin receptor antagonist **Action type** Antagonist **Target** Orexin receptor ### Investigated indications (3) - **Condition** Liver Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0001421 **Subject identifier** D008107 - **Condition** Sleep Apnea, Obstructive **Highest recorded phase** 1 **Condition identifier** EFO:0003918 **Subject identifier** D020181 - **Condition** Sleep Initiation and Maintenance Disorders **Highest recorded phase** 3 **Condition identifier** EFO:0004698 **Subject identifier** D007319 ### Open Targets indications (4) - **Condition identifier** EFO\_0001421 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003918 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004698 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0013600 **Highest recorded phase** 3 ### Trial references (6) - NCT04469023 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04469023) - NCT04573725 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04573725) - NCT05453136 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05453136) - NCT05461352 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05461352) - NCT04746105 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04746105) - NCT05624944 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05624944) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Heavy atoms** 133 **Monoisotopic mass** 1806.73816921 **Natural product** No ## Related records ### Trials (16) - A Clinical Pharmacology Study of TS-142 in Patients with Obstructive Sleep Apnea Hypopnea. - A Food Effect Study of TS-142 in Healthy Subjects - A Pharmacokinetic Study of TS-142 in Patients with Hepatic Impairment - A Phase I Study of TS-142 in Healthy Participants (Repeated Doses) - A Phase I Study of TS-142 in Healthy Participants (Single Doses) - A QT/QTc Evaluation Study of TS-142 in Healthy Adult Subjects - A Single Ascending and Repeated Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TS-142 in Healthy Participants - A Study to Evaluate Next Day Effects of TS-142 on Driving Performance in Healthy Subjects - A Study to Investigate the Next-day Residual Effects of TS-142 in Healthy Elderly Subjects - Drug-drug Interaction Study with TS-142 in Healthy Adult Subjects (concomitant Administration of Itraconazole) - Early Phase 2 Clinical Study of TS-142 in Patients with Insomnia Disorder - Late Phase II Study of TS-142 in Patients with Insomnia - Long-Term Study of TS-142 in Patients with Insomnia - Mass Balance Study of TS-142 in Healthy Adult Subjects. - [Phase III Study of TS-142 in Patients with Insomnia](https://trialight.com/data/trial/phase-iii-study-of-ts-142-in-patients-with-insomnia-2f0ba642-8986-42fb-9537-760154c5558e.md) - Safety, Pharmacokinetic, and Pharmacodynamic Study of TS-142 in Healthy Subjects ### In development for (3) - [Insomnia](https://trialight.com/data/condition/insomnia-57f6af86-fd71-567b-813f-5867cfd4790c.md) Phase 3 - [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1 - [Obstructive sleep apnea syndrome](https://trialight.com/data/condition/obstructive-sleep-apnea-syndrome-02928491-a2d7-50f4-a4b7-30b79e6771ff.md) Phase 1 ### Targets (2) - [HCRTR1](https://trialight.com/data/target/hcrtr1-fe2b8b6d-e646-5d68-8fcc-5f3c29444e6b.md) Orexin receptor antagonist - [HCRTR2](https://trialight.com/data/target/hcrtr2-c8fa6f8b-e837-58ac-8b0b-19ceb613dc17.md) Orexin receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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