> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/opevesostat-e2e44731-5c22-4113-8383-ea545425e9df > Record changed: 2026-10-13 # Opevesostat Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314533) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314533) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314533) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314533) **Drug name** Opevesostat Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314533) **Molecular weight** 418.52 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314533) **Structure (SMILES)** CS(=O)(=O)N1CCC(COc2coc(CN3Cc4ccccc4C3)cc2=O)CC1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314533) ### Other names (15) - mk 5684 - MK-5684 - odm 208 - Odm-208 - ODM-208 - odm208 - ODM208 - opevesostat - Opevesostat - opevesostat \[INN\] - OPEVESOSTAT \[USAN\] - Opevesostat \[WHO-DD\] - opevesostat inn - opevesostat usan - opevesostat who dd ## Identifiers **CAS registry numbers** - 2231294-96-3 **ChEMBL ID** CHEMBL5314533 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314533) **InChIKey** LHVKCOBGLZGRQZ-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314533) **PubChem compound IDs** - 135151902 **FDA ingredient codes (UNII)** - 1Z7MAV4KQC ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** opevesostat **Type** Synthetic organic **Drug name stem** \-stat ### Mechanisms of action - **Action** Inhibition **Action type** Inhibitor **Target** CYP11A1 **Gene symbol** CYP11A1 **Protein identifier** P05108 **Median affinity** 6.97 **Affinity units** pIC50 ### Investigated indications (3) - **Condition** Prostatic Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000196 **Subject identifier** D011471 - **Condition** Prostatic Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000673 **Subject identifier** D011471 - **Condition** Prostatic Neoplasms, Castration-Resistant **Highest recorded phase** 1 **Condition identifier** MONDO:0008315 **Subject identifier** D064129 ### Open Targets indications (6) - **Condition identifier** EFO\_0000673 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008170 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008315 - **Condition identifier** MONDO\_0008315 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0011962 **Highest recorded phase** 2 ### Trial references (6) - NCT03436485 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03436485) - NCT06104449 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06104449) - NCT06136598 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06136598) - NCT06136650 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06136650) - NCT06353386 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06353386) - NCT06136624 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06136624) ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 0 **Polar surface area** 80.06 **Calculated partition coefficient (ALogP)** 2.21 **Calculated partition coefficient (XLogP)** 1.3 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 6 **Heavy atoms** 29 **Molecular formula** C21H26N2O5S **Monoisotopic mass** 418.15624311 **Natural product** No ## Related records ### Trials (14) - [A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)](https://trialight.com/data/trial/a-clinical-study-of-ifinatamab-deruxtecan-based-treatment-99be48a0-44f7-46eb-bdf5-d3d2adc6018e.md) - A Drug-Drug Interaction Study of Carbamazepine and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-012) - A Drug-Drug Interaction Study of Diltiazem and MK-5684 in Healthy Adult Male Participants (MK-5684-011) - A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-017) - A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) - A Study of Opevesostat (MK-568)4 in Japanese Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-005) - A Study of Opevesostat (MK-5684) in China Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (MK-5684-001) - [A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)](https://trialight.com/data/trial/a-study-of-opevesostat-mk-5684-versus-alternative-next-40ece519-da89-4905-86a7-0c1a844d57e4.md) - A Study of the Absorption, Distribution, Metabolism, and Elimination of Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-008) - A Study to Evaluate Opevesostat (MK-5684) in Male Participants With Moderate Hepatic Impairment (MK-5684-009) - A Study to Evaluate the Effect of MK-5684 in Male Participants With Severe Renal Impairment (RI) and With End-stage Renal Disease (ESRD) (MK-5684-010) - Safety and Pharmacokinetics of ODM-208 in Patients With Metastatic Castration-resistant Prostate Cancer - [Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)](https://trialight.com/data/trial/study-of-opevesostat-mk-5684-versus-alternative-nha-in-mcrpc-332ed2a7-4705-40a6-a799-b3905fd1df96.md) - Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A) ### In development for (3) - [Metastatic prostate carcinoma](https://trialight.com/data/condition/metastatic-prostate-carcinoma-d5fb1084-bad5-5db6-8240-897dc47ea451.md) Phase 3 - [Prostate adenocarcinoma](https://trialight.com/data/condition/prostate-adenocarcinoma-84e3e3af-1ae1-5760-8157-8d9fc0cff608.md) Phase 3 - [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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