> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/ompekimig-8307899f-ccd5-4b68-ba81-961999803d79 > Record changed: 2026-10-13 # Ompekimig Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068473) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068473) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068473) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068473) **Drug name** Ompekimig Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068473) ### Other names (11) - immunoglobulin anti human macaca fascicularis interleukin 13 human mus musculus monoclonal pf 07296735 κ chain fusion protein with peptide linker ggggs fusion protein with immunoglobulin g1 448 glutamic acid 461 alanine 462 alanine 464 alanine 595 glutamic acid 655 leucine 661 serine anti human macaca fascicularis interleukin 4 human mus musculus monoclonal pf 07296735 γ1 chain cys453 cys230 cys456 cys233 bis disulfide with immunoglobulin g1 225 arginine 238 alanine 239 alanine 241 alanine 413 arginine 432 leucine 438 serine anti human macaca fascicularis interleukin 33 human sprague dawley rat monoclonal pf 07275307 γ1 chain cys218 cys 221 disulfide with immunoglobulin anti human macaca fascicularis interleukin 13 recombinant heavy chain variable constant domain 1 fusion protein with peptide linker epksc cys447 cys218 disulfide with immunoglobulin anti human macaca fascicularis interleukin 4 human mus musculus monoclonal pf 07296735 κ chain cys224 cys213 disulfide with immunoglobulin anti human macaca fascicularis interleukin 33 human sprague dawley rat monoclonal pf 07275307 κ chain cys453 cys230 cys456 cys233 bis disulfide with immunoglobulin g1 225 arginine 238 alanine 239 alanine 241 alanine 413 arginine 432 leucine 438 serine anti human macaca fascicularis interleukin 33 human sprague dawley rat monoclonal pf 07275307 γ1 chain cys218 cys 221 disulfide with immunoglobulin anti human macaca fascicularis interleukin 13 recombinant heavy chain variable constant domain 1 fusion protein with peptide linker epksc cys447 cys218 disulfide with immunoglobulin anti human macaca fascicularis interleukin 4 human mus musculus monoclonal pf 07296735 κ chain cys224 cys213 disulfide with immunoglobulin anti human macaca fascicularis interleukin 33 human sprague dawley rat monoclonal pf 07275307 κ chain - Immunoglobulin, anti-(human/Macaca fascicularis interleukin 13) (human-Mus musculus monoclonal PF-07296735 κ-chain) fusion protein with peptide linker (GGGGS) fusion protein with immunoglobulin G1 \[448-glutamic acid,461-alanine,462-alanine,464-alanine,595-glutamic acid,655-leucine,661-serine\] anti-(human/Macaca fascicularis interleukin 4) (human-Mus musculus monoclonal PF-07296735 γ1-chain), (Cys453→Cys230′),(Cys456→Cys233′)-bis(disulfide) with immunoglobulin G1 \[225-arginine,238-alanine,239-alanine,241-alanine,413-arginine,432-leucine,438-serine\] anti-(human/Macaca fascicularis interleukin 33) (human-Sprague-Dawley rat monoclonal PF-07275307 γ1-chain), (Cys218→Cys-221")-disulfide with immunoglobulin anti-(human/Macaca fascicularis interleukin 13) (recombinant heavy chain variable-constant domain 1) fusion protein with peptide linker (EPKSC), (Cys447→Cys218′′′)-disulfide with immunoglobulin anti-(human/Macaca fascicularis interleukin 4) (human-Mus musculus monoclonal PF-07296735 κ-chain), (Cys224′→Cys213′′′′)-disulfide with immunoglobulin anti-(human/Macaca fascicularis interleukin 33) (human-Sprague-Dawley rat monoclonal PF-07275307 κ-chain) (Cys453→Cys230′),(Cys456→Cys233′)-bis(disulfide) with immunoglobulin G1 \[225-arginine,238-alanine,239-alanine,241-alanine,413-arginine,432-leucine,438-serine\] anti-(human/Macaca fascicularis interleukin 33) (human-Sprague-Dawley rat monoclonal PF-07275307 γ1-chain), (Cys218→Cys-221”)-disulfide with immunoglobulin anti-(human/Macaca fascicularis interleukin 13) (recombinant heavy chain variable-constant domain 1) fusion protein with peptide linker (EPKSC), (Cys447→Cys218′′′)-disulfide with immunoglobulin anti-(human/Macaca fascicularis interleukin 4) (human-Mus musculus monoclonal PF-07296735 κ-chain), (Cys224′→Cys213′′′′)-disulfide with immunoglobulin anti-(human/Macaca fascicularis interleukin 33) (human-Sprague-Dawley rat monoclonal PF-07275307 κ-chain) - ompekimig - Ompekimig - ompekimig \[INN\] - OMPEKIMIG \[USAN\] - ompekimig inn - ompekimig usan - pf 07264660 - Pf-07264660 - PF-07264660 ## Identifiers **CAS registry numbers** - 2981477-39-6 **ChEMBL ID** CHEMBL6068473 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068473) **FDA ingredient codes (UNII)** - 7S9F79AD9Z ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-mig ### Investigated indications (3) - **Condition** Dermatitis, Atopic **Highest recorded phase** 2 **Condition identifier** EFO:0000274 **Subject identifier** D003876 - **Condition** Dermatitis **Highest recorded phase** 1 **Condition identifier** HP:0011123 **Subject identifier** D003872 - **Condition** Inflammation **Highest recorded phase** 1 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (4) - **Condition identifier** EFO\_0000274 **Highest recorded phase** 2 - **Condition identifier** HP\_0011123 - **Condition identifier** MONDO\_0004980 **Highest recorded phase** 2 - **Condition identifier** MP\_0001845 ### Trial references - NCT05995964 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05995964) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (7) - **Component** DualFab anti-IL-13 LC-linker-anti-IL-4 HC; (H) **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCKASESVDHFGWSLVHWYQQKPGKAPKLLIYRASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGGGSEVTLRESGPALVKPTQTLTLTCTFSGFSLSNFGEGLSWIRQPPGKGLEWLAHIYWDDDKRYNPSLKSRLTISKDTSRNQVVLTMTNMDPVDTATYYCARRETVFYWYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCEKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCEVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHSHYTQKSLSLSPGK - **Component** Glycosylation sites (N) **Sequence** 524 $ 301''' - **Component** Disulfide bridges **Sequence** 222'-95' $ 22'''-96''' $ 23''''-88'''' $ 23-92 $ 23''-92'' $ 133''''-193'''' $ 138-198 $ 138''-198'' $ 145'-201' $ 148'''-204''' $ 218-221' $ 224'''-213'''' $ 245-320 $ 265'''-325''' $ 371-427'' $ 371'''-429'' $ 447-218'' $ 453-230''' $ 456-233''' $ 488-548 $ 594-652 - **Component** Single Fab Anti-IL-33 (L'''') **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCRASQPIHNHLDWYQQKPGKAPKLLIYFGKNLQEGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCFQYKKGWSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Single Fab Anti-IL-33 HC; (H''') **Type** Protein **Sequence** EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYWMYWVRQAPGKGLEWVAAITPNAGEDYYPESVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARGQYYYTKYSLGYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCRKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVLHEALHSHYTQKSLSLSPGK - **Component** DualFab Anti-IL-13 mFd; (M') **Type** Protein **Sequence** EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVASISSGDTTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARNEGYYFGLTLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC - **Component** DualFab Anti-IL-4 LC; (L'') **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCRASQSVDEEGDSYMNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNKDPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC ## Related records ### Trials (3) - A Preliminary Study to Evaluate PF-07264660 in Healthy Participants - [A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis](https://trialight.com/data/trial/a-study-to-learn-about-two-study-medicines-pf-07275315-and-d318ca7a-09b3-4260-9698-26637c1cbe41.md) - A Study to Learn More About the Study Medicine PF-07264660 in Healthy Chinese Adult Participants ### In development for (2) - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2 - [Dermatitis](https://trialight.com/data/condition/dermatitis-cf8b2157-f593-5138-bd3d-f2a74343308e.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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