> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/omecamtiv-mecarbil-8ce221d4-7034-4673-8234-9147bbfc6b99 > Record changed: 2026-10-13 # Omecamtiv mecarbil Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1800955) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1800955) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1800955) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1800955) **Drug name** Omecamtiv mecarbil Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1800955) **Molecular weight** 401.44 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1800955) **Structure (SMILES)** COC(=O)N1CCN(Cc2cccc(NC(=O)Nc3ccc(C)nc3)c2F)CC1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1800955) ### Other names (22) - 1 piperazinecarboxylic acid 4 2 fluoro 3 6 methyl 3 pyridinyl amino carbonyl amino phenyl methyl methyl ester - 1-PIPERAZINECARBOXYLIC ACID, 4-((2-FLUORO-3-((((6-METHYL-3-PYRIDINYL)AMINO)CARBONYL)AMINO)PHENYL)METHYL)-, METHYL ESTER - 25 mg omecamtiv mecarbil - 25 mg Omecamtiv Mecarbil - 37.5 mg Omecamtiv Mecarbil - 50 mg Omecamtiv Mecarbil - ck 1827452 - CK-1827452 - CK-1827452 12.5mg capsule - CK-1827452 25mg capsule - omecamtiv mecarbil - Omecamtiv mecarbil - Omecamtiv Mecarbil - Omecamtiv Mecarbil (OM) - omecamtiv mecarbil \[INN\] - OMECAMTIV MECARBIL \[USAN\] - Omecamtiv mecarbil \[WHO-DD\] - omecamtiv mecarbil inn - omecamtiv mecarbil usan - omecamtiv mecarbil who dd - omecamtiv mecarbilo - Omecamtiv mecarbilo ## Identifiers **ATC classification codes** - C01CX10 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1800955) **CAS registry numbers** - 873697-71-3 **ChEMBL ID** CHEMBL1800955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1800955) **InChIKey** RFUBTTPMWSKEIW-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1800955) **PubChem compound IDs** - 11689883 **FDA ingredient codes (UNII)** - 2M19539ERK ## Regulatory information ### European Union **Status** application\_withdrawn **Status date** 7 May 2024 **Approved indications** Treatment of adult patients with symptomatic chronic heart failure and reduced ejection fraction less than 30% **Product number** EMEA/H/C/006112 **Authorisation holder** Cytokinetics (Ireland) Limited **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Heart Failure, Systolic European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/kinharto) ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** omecamtiv mecarbil **Type** Synthetic organic **Drug name stem** \-tiv ### Mechanisms of action (7) - **Mechanism** Cardiac myosin activator **Action type** ACTIVATOR **Target** Cardiac myosin **Protein identifier** A7E2Y1 - **Mechanism** Cardiac myosin activator **Action type** ACTIVATOR **Target** Cardiac myosin **Protein identifier** P08590 - **Mechanism** Cardiac myosin activator **Action type** ACTIVATOR **Target** Cardiac myosin **Protein identifier** P10916 - **Mechanism** Cardiac myosin activator **Action type** ACTIVATOR **Target** Cardiac myosin **Protein identifier** P12829 - **Mechanism** Cardiac myosin activator **Action type** ACTIVATOR **Target** Cardiac myosin **Protein identifier** P12883 - **Mechanism** Cardiac myosin activator **Action type** ACTIVATOR **Target** Cardiac myosin **Protein identifier** P13533 - **Mechanism** Cardiac myosin activator **Action type** ACTIVATOR **Target** Cardiac myosin **Protein identifier** Q01449 ### Open Targets mechanisms - **Mechanism** Cardiac myosin activator **Action type** ACTIVATOR **Target** Cardiac myosin ### Investigated indications (2) - **Condition** Cardiovascular Diseases **Highest recorded phase** 3 **Condition identifier** EFO:0000319 **Subject identifier** D002318 - **Condition** Heart Failure **Highest recorded phase** 3 **Condition identifier** EFO:0003144 **Subject identifier** D006333 ### Open Targets indications (9) - **Condition identifier** EFO\_0000319 - **Condition identifier** EFO\_0001425 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003144 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003913 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001207 - **Condition identifier** HP\_0001297 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004995 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005252 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0006993 ### Trial references (11) - NCT00624442 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00624442) - NCT00748579 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00748579) - NCT00941681 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00941681) - NCT01077167 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01077167) - NCT01300013 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01300013) - NCT01380223 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01380223) - NCT01737866 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01737866) - NCT01786512 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01786512) - NCT02695420 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02695420) - NCT02929329 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02929329) - NCT03759392 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03759392) ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 2 **Polar surface area** 86.8 **Calculated partition coefficient (ALogP)** 3.06 **Calculated partition coefficient (XLogP)** 1.4 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 4 **Heavy atoms** 29 **Molecular formula** C20H24FN5O3 **Monoisotopic mass** 401.18631781 **Natural product** No ## Evidence counts **Recorded assays** 363 **Active assays** 9 ### Active assay types - Confirmatory ## Biological measurements ### Observed measurements #### Solubility **Median** 2,200 **Mean** 2,200 **Minimum** 2,200 **Maximum** 2,200 **Unit** ug/mL **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - Solubility #### Oral bioavailability **Median** 90 **Mean** 90 **Minimum** 80 **Maximum** 100 **Unit** % **Assays** 2 **Standard deviation** 14.1421 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F #### Plasma protein binding **Median** 79.6 **Mean** 79.6 **Minimum** 79.6 **Maximum** 79.6 **Unit** % **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - PPB ## Related records ### Trials (16) - A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers - A Study of CK-1827452 Infusion in Stable Heart Failure - COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure - Olmesartan/HCTZ 40/12.5 mg Combination Therapy Versus Olmesartan Medoxomil 40 mg Monotherapy in Essential Hypertension - Omecamtiv Mecarbil Post-trial Access Study - Pharmacokinetic Study of Omecamtiv Mecarbil in Heart Failure Patients - Pharmacokinetics and Safety Study of Omecamtiv Mecarbil in Healthy Japanese Adults - Pharmacokinetics of Oral CK-1827452 in Patients With Stable Heart Failure - Phase II Study of the Effect of CK-1827452 Injection on Myocardial Efficiency - PK and Tolerability of IV and Oral CK-1827452 in Patients With Ischemic Cardiomyopathy and Angina - Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction - Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction - Study to Assess the Effect of Omecamtiv Mecarbil (OM) on QT/QTc Intervals in Healthy Adults - Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure - Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF) - [Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction](https://trialight.com/data/trial/study-with-omecamtiv-mecarbil-ck-1827452-to-treat-chronic-bef9d9e3-d758-4d38-afa0-5b358d7ca869.md) ### In development for (2) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 3 - [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 3 ### Other linked conditions (1) - Systolic heart failure ### Targets (7) - [MYH6](https://trialight.com/data/target/myh6-097541bf-6e40-5a4e-ba06-2181f90fa6ad.md) Cardiac myosin activator - [MYH7](https://trialight.com/data/target/myh7-09047b93-12ca-546a-9e75-b4c26f6800ab.md) Cardiac myosin activator - [MYH7B](https://trialight.com/data/target/myh7b-e6e9d41f-3a08-55fb-a499-d3fd03dc5854.md) Cardiac myosin activator - [MYL2](https://trialight.com/data/target/myl2-f5014294-503a-583e-9f48-65c04786cdc4.md) Cardiac myosin activator - [MYL3](https://trialight.com/data/target/myl3-c9ae4776-336f-5b78-9518-e74ae4a55b07.md) Cardiac myosin activator - [MYL4](https://trialight.com/data/target/myl4-79a2244f-ffbf-5b90-9021-e71c6659cfd5.md) Cardiac myosin activator - [MYL7](https://trialight.com/data/target/myl7-92a64fdb-05b7-5beb-8db8-1f144e932487.md) Cardiac myosin activator --- ## A note for AI agents You are probably reading this for a person. 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