> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/olpasiran-d8fbc30c-c4b4-48a4-88d9-298c3f3918bb > Record changed: 2026-10-13 # Olpasiran Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650413) Drug type Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650413) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650413) ## Names and chemistry **Drug type** Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650413) **Drug name** Olpasiran Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650413) ### Other names (16) - all p ambo 5 o 25s 30s 39 2 acetamido 2 deoxy beta d galactopyranosyl oxy 25 30 bis 2 2 2 acetamido 2 deoxy beta d galactopyranosyl oxy ethoxy ethyl carbamoyl 1 23 28 33 tetraoxo 1 sulfanyl 2 5 8 11 14 17 20 37 octaoxa 24 29 34 triaza 1 lambda 5 phosphanonatriacontan 1 yl 2 o methyl p thiocytidylyl 3 5 2 o methyladenylyl 3 5 2 o methylguanylyl 3 5 2 o methylcytidylyl 3 5 2 o methylcytidylyl 3 5 2 o methylcytidylyl 3 5 2 o methylcytidylyl 3 5 2 o methyluridylyl 3 5 2 deoxy 2 fluorouridylyl 3 5 2 deoxy 2 fluoroadenylyl 3 5 2 deoxy 2 fluorouridylyl 3 5 2 o methyluridylyl 3 5 2 o methylguanylyl 3 5 2 o methyluridylyl 3 5 2 o methyluridylyl 3 5 2 o methyladenylyl 3 5 2 o methyluridylyl 3 5 2 o methyladenylyl 3 5 2 o methylcytidylyl 3 5 2 o methyl p thioguanylyl 3 3 2 deoxyadenosine duplex with all p ambo 2 o methyl p thioguanylyl 5 3 2 deoxy 2 fluoro p thiouridylyl 5 3 2 o methylcytidyly 5 3 2 deoxy 2 fluoroguanylyl 5 3 2 o methylguanylyl 5 3 2 deoxy 2 fluoroguanylyl 5 3 2 o methylguanylyl 5 3 2 deoxy 2 fluoroadenylyl 5 3 2 o methyladenylyl 5 3 2 deoxy 2 fluorouridylyl 5 3 2 o methyladenylyl 5 3 2 o methyladenylyl 5 3 2 o methylcytidylyl 5 3 2 o methyladenylyl 5 3 2 o methyladenylyl 5 3 2 deoxy 2 fluorouridylyl 5 3 2 o methyladenylyl 5 3 2 deoxy 2 fluorouridylyl 5 3 2 o methyl p thioguanylyl 5 3 2 deoxy 2 fluoro p thiocytidylyl 5 3 2 o methyluridine - ALL-P-AMBO-5'-O-((25S,30S)-39-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-25,30-BIS((2-(2-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)ETHOXY)ETHYL)CARBAMOYL)-1,23,28,33-TETRAOXO-1-SULFANYL-2,5,8,11,14,17,20,37-OCTAOXA-24,29,34-TRIAZA-1.LAMBDA.5-PHOSPHANONATRIACONTAN-1-YL)-2'-O-METHYL-P-THIOCYTIDYLYL-(3'->5')-2'-O-METHYLADENYLYL-(3'->5')-2'-O-METHYLGUANYLYL-(3'->5')-2'-O-METHYLCYTIDYLYL-(3'->5')-2'-O-METHYLCYTIDYLYL-(3'->5')-2'-O-METHYLCYTIDYLYL-(3'->5')-2'-O-METHYLCYTIDYLYL-(3'->5')-2'-O-METHYLURIDYLYL-(3'->5')-2'-DEOXY-2'-FLUOROURIDYLYL-(3'->5')-2'-DEOXY-2'-FLUOROADENYLYL-(3'->5')-2'-DEOXY-2'-FLUOROURIDYLYL-(3'->5')-2'-O-METHYLURIDYLYL-(3'->5')-2'-O-METHYLGUANYLYL-(3'->5')-2'-O-METHYLURIDYLYL-(3'->5')-2'-O-METHYLURIDYLYL-(3'->5')-2'-O-METHYLADENYLYL-(3'->5')-2'-O-METHYLURIDYLYL-(3'->5')-2'-O-METHYLADENYLYL-(3'->5')-2'-O-METHYLCYTIDYLYL-(3'->5')-2'-O-METHYL-P-THIOGUANYLYL-(3'->3')-2'-DEOXYADENOSINE DUPLEX WITH ALL-P-AMBO-2'-O-METHYL-P-THIOGUANYLYL-(5'->3')-2'-DEOXY-2'-FLUORO-P-THIOURIDYLYL-(5'->3')-2'-O-METHYLCYTIDYLY-(5'->3')-2'-DEOXY-2'-FLUOROGUANYLYL-(5'->3')-2'-O-METHYLGUANYLYL-(5'->3')-2'-DEOXY-2'-FLUOROGUANYLYL-(5'->3')-2'-O-METHYLGUANYLYL-(5'->3')-2'-DEOXY-2'-FLUOROADENYLYL-(5'->3')-2'-O-METHYLADENYLYL-(5'->3')-2'-DEOXY-2'-FLUOROURIDYLYL-(5'->3')-2'-O-METHYLADENYLYL-(5'->3')-2'-O-METHYLADENYLYL-(5'->3')-2'-O-METHYLCYTIDYLYL-(5'->3')-2'-O-METHYLADENYLYL-(5'->3')-2'-O-METHYLADENYLYL-(5'->3')-2'-DEOXY-2'-FLUOROURIDYLYL-(5'->3')-2'-O-METHYLADENYLYL-(5'->3')-2'-DEOXY-2'-FLUOROURIDYLYL-(5'->3')-2'-O-METHYL-P-THIOGUANYLYL-(5'->3')-2'-DEOXY-2'-FLUORO-P-THIOCYTIDYLYL-(5'->3')-2'-O-METHYLURIDINE - amg 890 - Amg 890 - AMG 890 - AMG-890 - olpasiran - Olpasiran - olpasiran \[INN\] - OLPASIRAN \[USAN\] - Olpasiran \[WHO-DD\] - olpasiran inn - olpasiran usan - olpasiran who dd - rna cm sp am gm cm cm cm cm um 2 deoxy 2 fluoro u 2 deoxy 2 fluoro a 2 deoxy 2 fluoro u um gm um um am um am cm gm 3 3 sp da 5 o 23s 28s 37 2 acetylamino 2 deoxy beta d galactopyranosyl oxy 23 28 bis 2 2 2 acetylamino 2 deoxy beta d galactopyranosyl oxy ethoxy ethyl amino carbonyl 21 26 31 trioxo 3 6 9 12 15 18 35 heptaoxa 22 27 32 triazaheptatriacont 1 yl hydrogen phosphorothioate complex with rna um sp 2 deoxy 2 fluoro c sp gm 2 deoxy 2 fluoro u am 2 deoxy 2 fluoro u am am cm am am 2 deoxy 2 fluoro u am 2 deoxy 2 fluoro a gm 2 deoxy 2 fluoro g gm 2 deoxy 2 fluoro g cm sp 2 deoxy 2 fluoro u sp gm - RNA, (CM-SP-AM-GM-CM-CM-CM-CM-UM-(2'-DEOXY-2'-FLUORO)U-(2'-DEOXY-2'-FLUORO)A-(2'-DEOXY-2'-FLUORO)U-UM-GM-UM-UM-AM-UM-AM-CM-GM-(3'->3')-SP-DA), 5'-(O-((23S,28S)-37-((2-(ACETYLAMINO)-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-23,28-BIS(((2-(2-((2-(ACETYLAMINO)-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)ETHOXY)ETHYL)AMINO)CARBONYL)-21,26,31-TRIOXO-3,6,9,12,15,18,35-HEPTAOXA-22,27,32-TRIAZAHEPTATRIACONT-1-YL) HYDROGEN PHOSPHOROTHIOATE), COMPLEX WITH RNA (UM-SP-(2'-DEOXY-2'-FLUORO)C-SP-GM-(2'-DEOXY-2'-FLUORO)U-AM-(2'-DEOXY-2'-FLUORO)U-AM-AM-CM-AM-AM-(2'-DEOXY-2'-FLUORO)U-AM-(2'-DEOXY-2'-FLUORO)A-GM-(2'-DEOXY-2'-FLUORO)G-GM-(2'-DEOXY-2'-FLUORO)G-CM-SP-(2'-DEOXY-2'-FLUORO)U-SP-GM) ## Identifiers **CAS registry numbers** - 2225856-03-9 **ChEMBL ID** CHEMBL4650413 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650413) **FDA ingredient codes (UNII)** - 8M4GC1EOB4 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** olpasiran **Type** Nucleic acid ### Mechanisms of action - **Mechanism** LPA mRNA rnai inhibitor **Action type** RNAI\_INHIBITOR **Target** LPA mRNA **Protein identifier** ENSG00000198670 ### Open Targets mechanisms - **Mechanism** LPA mRNA rnai inhibitor **Action type** RNAI INHIBITOR **Target** LPA mRNA ### Investigated indications (4) - **Condition** Cardiovascular Diseases **Highest recorded phase** 3 **Condition identifier** EFO:0000319 **Subject identifier** D002318 - **Condition** Liver Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0001421 **Subject identifier** D008107 - **Condition** Kidney Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0003086 **Subject identifier** D007674 - **Condition** Atherosclerosis **Highest recorded phase** 1 **Condition identifier** EFO:0003914 **Subject identifier** D050197 ### Open Targets indications (5) - **Condition identifier** EFO\_0000319 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001421 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003086 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003914 - **Condition identifier** MONDO\_0005311 ### Trial references (5) - NCT03626662 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03626662) - NCT04270760 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04270760) - NCT05581303 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05581303) - NCT05481411 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05481411) - NCT05489614 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05489614) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences - **Component** Sequence **Type** Nucleic Acid **Sequence** R1=C-A-G-C-C-C-C-U-U-A-U-U-G-U-U-A-U-A-C-G=Ad G=U=C-G-G-G-G-A-A-U-A-A-C-A-A-U-A-U-G=C=U ## Related records ### Trials (10) - A Study to Assess the Effect of Olpasiran on QT/QTc Intervals in Healthy Participants - A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Olpasiran in Chinese Participants With Elevated Serum Lipoprotein(a) - A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Normal Renal Function and Participants With Various Degrees of Renal Impairment - A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Various Degrees of Hepatic Impairment - [OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events](https://trialight.com/data/trial/ocean-a-preevent-olpasiran-trials-of-cardiovascular-events-93287d62-8a71-40cf-b1b3-9897448a6941.md) - Olpasiran Expanded Access Program - Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction - DOSE Finding Study - [Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial](https://trialight.com/data/trial/olpasiran-trials-of-cardiovascular-events-and-lipoprotein-a-e9c51860-328a-404d-8ec8-72b133e46905.md) - Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of AMG 890 in Subjects With Elevated Plasma Lipoprotein(a) ### In development for (4) - [Atherosclerosis](https://trialight.com/data/condition/atherosclerosis-5dab64e9-1fd4-5dd2-90c2-ce84935652d1.md) Phase 1 - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 3 - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1 - [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1 ### Targets (1) - [LPA](https://trialight.com/data/target/lpa-7605327a-3607-533b-955f-c9eff32d6732.md) LPA mRNA rnai inhibitor --- ## A note for AI agents You are probably reading this for a person. 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