> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/olomorasib-96d5c218-8b5d-4ae5-b9d4-970dd492f808
> Record changed: 2026-10-13

# Olomorasib

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068410)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068410)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068410)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068410)

**Drug name**

Olomorasib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068410)

**Molecular weight**

528.97

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068410)

**Structure (SMILES)**

C=CC(=O)N1CCN2C(=O)c3cc(F)c(-c4ccc(F)c5sc(N)c(C#N)c45)c(Cl)c3OCC\[C@H\]2C1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068410)

### Other names (13)

- ly 3537982
- LY-3537982
- ly3537982
- Ly3537982
- LY3537982
- olomorasib
- Olomorasib
- olomorasib \[INN\]
- OLOMORASIB \[USAN\]
- Olomorasib \[WHO-DD\]
- olomorasib inn
- olomorasib usan
- olomorasib who dd

## Identifiers

**CAS registry numbers**

- 2771246-13-8

**ChEMBL ID**

CHEMBL6068410

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068410)

**InChIKey**

OZUPICRWMLEFCS-LBPRGKRZSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068410)

**PubChem compound IDs**

- 156472638

**FDA ingredient codes (UNII)**

- C2VJ83PSN7

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

olomorasib

**Type**

Synthetic organic

**Drug name stem**

\-rasib

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
KRAS

**Gene symbol**  
KRAS

**Protein identifier**  
P01116

**Median affinity**

9.02

**Affinity units**  
pIC50

### Investigated indications

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369

### Open Targets indications (5)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
HP\_0000083

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0001399

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
3

### Trial references

- NCT06235983  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06235983)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

1

**Polar surface area**

99.66

**Calculated partition coefficient (ALogP)**

4.58

**Calculated partition coefficient (XLogP)**

4.8

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

2

**Heavy atoms**

36

**Molecular formula**

C25H19ClF2N4O3S

**Monoisotopic mass**

528.0834457

**Natural product**

No

## Evidence counts

**Recorded assays**

56

**Active assays**

3

### Active assay types

- Confirmatory

## Related records

### Trials (15)

- A Drug-Drug Interaction Study of LY3537982 on Midazolam, Digoxin, and Rosuvastatin in Healthy Participants
- A Study of \[14C\]-LY3537982 in Healthy Participants
- A Study of Amivantamab and Olomorasib Combination Therapy in Participants With Metastatic Non-Small Cell Lung Cancer
- [A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer](https://trialight.com/data/trial/a-study-of-first-line-olomorasib-ly3537982-and-pembrolizumab-38b7e50a-d236-4c05-adcc-ba5bb20a9907.md)
- A Study of LY3537982 in Chinese Participants With Advanced Solid Tumors
- A Study of LY3537982 in Participants With Kidney Problems Compared With Participants With Normal Kidney Function
- A Study of Multiple Olomorasib (LY3537982) Capsules in Healthy Participants
- [A Study of Olomorasib (LY3537982) in Healthy Japanese Participants](https://trialight.com/data/trial/a-study-of-olomorasib-ly3537982-in-healthy-japanese-5adb93b0-1405-4633-bc22-e8b783ed958d.md)
- A Study of Olomorasib (LY3537982) in Healthy Participants
- A Study of Olomorasib (LY3537982) in Participants With Hepatic Impairment and Healthy Participants
- A Study of the Effect of Food on LY3537982 in Healthy Participants
- A Study of the Effects of Itraconazole or Carbamazepine on LY3537982 in Healthy Participants
- Olomorasib + Pembrolizumab KRAS G12C Mutant, PD-L1 TPS 1-49% Locally Advanced or Metastatic NSCLC
- Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)
- Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

### In development for (1)

- Neoplasm Phase 1

---

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