> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/olmesartan-f08e3b2e-f2f4-481f-b3c2-298612dfb4b3
> Record changed: 2026-10-13

# Olmesartan

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1516)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1516)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1516)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1516)

**Drug name**

Olmesartan

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1516)

**Molecular weight**

446.51

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1516)

**Structure (SMILES)**

CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn\[nH\]2)cc1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1516)

### Other names (25)

- 1h imidazole 5 carboxylic acid 4 1 hydroxy 1 methylethyl 2 propyl 1 2 1h tetrazol 5 yl 1 1 biphenyl 4 yl methyl
- 1H-IMIDAZOLE-5-CARBOXYLIC ACID, 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1-((2'-(1H-TETRAZOL-5-YL) (1,1'-BIPHENYL)-4-YL)METHYL)-
- azelnidipine 8 mg and olmesartan 20 mg
- nsc 759810
- NSC-759810
- olmesartan
- Olmesartan
- olmesartan \[INN\]
- OLMESARTAN \[MI\]
- OLMESARTAN \[USAN\]
- OLMESARTAN \[VANDF\]
- Olmesartan \[WHO-DD\]
- olmesartan inn
- OLMESARTAN MEDOXOMIL IMPURITY A \[EP IMPURITY\]
- olmesartan medoxomil impurity a ep impurity
- olmesartan medoxomil impurity olmesartan
- olmesartan medoxomil impurity olmesartan usp impurity
- Olmesartan medoxomil impurity, olmesartan-
- OLMESARTAN MEDOXOMIL IMPURITY, OLMESARTAN- \[USP IMPURITY\]
- olmesartan mi
- olmesartan usan
- olmesartan vandf
- olmesartan who dd
- rnh 6270
- RNH-6270

## Identifiers

**CAS registry numbers**

- 144689-24-7

**ChEMBL ID**

CHEMBL1516

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1516)

**InChIKey**

VTRAEEWXHOVJFV-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1516)

**PubChem compound IDs**

- 158781

**RxNorm IDs (RxCUI)**

- 321064

**FDA ingredient codes (UNII)**

- 8W1IQP3U10

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

olmesartan

**Type**

Synthetic organic

**Drug name stem**

\-sartan

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (2)

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
AT1 receptor

**Gene symbol**  
AGTR1

**Protein identifier**  
P30556

**Median affinity**

8.1

**Affinity units**  
pIC50

**Primary target**  
Yes
- **Mechanism**  
Type-1 angiotensin II receptor antagonist

**Action type**  
Antagonist

**Target**  
Type-1 angiotensin II receptor

**Protein identifier**  
P30556

### Open Targets mechanisms

- **Mechanism**  
Type-1 angiotensin II receptor antagonist

**Action type**  
Antagonist

**Target**  
Type-1 angiotensin II receptor

### Investigated indications (7)

- **Condition**  
Atrial Fibrillation

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000275

**Subject identifier**  
D001281
- **Condition**  
Hypertension

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000537

**Subject identifier**  
D006973
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000694

**Subject identifier**  
D045169
- **Condition**  
Stroke

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000712

**Subject identifier**  
D020521
- **Condition**  
Arrhythmias, Cardiac

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004269

**Subject identifier**  
D001145
- **Condition**  
Essential Hypertension

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0001134

**Subject identifier**  
D000075222
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (12)

- **Condition identifier**  
EFO\_0000537
- **Condition identifier**  
EFO\_0000712

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000822

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0001134

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0001422
- **Condition identifier**  
MONDO\_0002525

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005044

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005148
- **Condition identifier**  
MONDO\_0021187

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_1060198

**Highest recorded phase**  
2
- **Condition identifier**  
Orphanet\_309005

**Highest recorded phase**  
3

### Reported adverse events (73)

- **Event**  
abdominal hernia

**Reports**  
67

**Reporting signal score**

177.654
- **Event**  
acquired oesophageal web

**Reports**  
29

**Reporting signal score**

112.812
- **Event**  
acute kidney injury

**Reports**  
1,098

**Reporting signal score**  
1,936.97
- **Event**  
aortic valve stenosis

**Reports**  
12

**Reporting signal score**

46.5893
- **Event**  
barrett's oesophagus

**Reports**  
75

**Reporting signal score**

239.577
- **Event**  
blood pressure increased

**Reports**  
186

**Reporting signal score**

106.864
- **Event**  
bronchial secretion retention

**Reports**  
12

**Reporting signal score**

54.7947
- **Event**  
bronchial wall thickening

**Reports**  
12

**Reporting signal score**

57.3636
- **Event**  
chest x-ray abnormal

**Reports**  
12

**Reporting signal score**

37.6867
- **Event**  
cholecystitis

**Reports**  
101

**Reporting signal score**

193.669
- **Event**  
cholecystitis chronic

**Reports**  
97

**Reporting signal score**

371.799
- **Event**  
cholelithiasis

**Reports**  
193

**Reporting signal score**

336.088
- **Event**  
chronic kidney disease

**Reports**  
289

**Reporting signal score**

654.08
- **Event**  
clostridium difficile colitis

**Reports**  
74

**Reporting signal score**

115.936
- **Event**  
coeliac disease

**Reports**  
275

**Reporting signal score**  
1,002.69
- **Event**  
colitis microscopic

**Reports**  
83

**Reporting signal score**

208.913
- **Event**  
colitis ulcerative

**Reports**  
108

**Reporting signal score**

134.383
- **Event**  
colon adenoma

**Reports**  
42

**Reporting signal score**

121.952
- **Event**  
constipation

**Reports**  
622

**Reporting signal score**

746.102
- **Event**  
dehydration

**Reports**  
267

**Reporting signal score**

178.326
- **Event**  
diarrhoea

**Reports**  
802

**Reporting signal score**

364.793
- **Event**  
diverticulitis

**Reports**  
592

**Reporting signal score**  
1,678.81
- **Event**  
diverticulum

**Reports**  
580

**Reporting signal score**  
2,219.68
- **Event**  
diverticulum intestinal

**Reports**  
484

**Reporting signal score**  
2,075.11
- **Event**  
dizziness

**Reports**  
625

**Reporting signal score**

301.511

And 48 more, listed on the interactive page.

### Trial references (20)

- NCT00098137  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00098137)
- NCT00139698  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00139698)
- NCT00902538  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00902538)
- NCT01599104  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01599104)
- NCT01615198  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01615198)
- NCT01785472  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01785472)
- NCT00362115  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00362115)
- NCT00696241  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00696241)
- NCT00696436  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00696436)
- NCT00759551  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00759551)
- NCT01613209  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01613209)
- NCT01692301  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01692301)
- NCT01870739  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01870739)
- NCT01876368  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01876368)
- NCT02483936  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02483936)
- NCT02493322  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02493322)
- NCT05103332  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05103332)
- NCT05110898  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05110898)
- NCT03655964  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03655964)
- NCT04606563  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04606563)

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

3

**Polar surface area**

129.81

**Calculated partition coefficient (ALogP)**

3.66

**Calculated partition coefficient (XLogP)**

3.2

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

8

**Heavy atoms**

33

**Molecular formula**

C24H26N6O3

**Monoisotopic mass**

446.20663871

**Natural product**

Yes

## Evidence counts

**Recorded assays**

760

**Active assays**

13

### Active assay types (3)

- Confirmatory
- Other
- Screening

## Pharmacologic actions

- Antihypertensive Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000959.html)
- Angiotensin II Type 1 Receptor Blockers  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D047228.html)

## Biological measurements

### Observed measurements

#### Oral bioavailability

**Median**

26

**Mean**

26

**Minimum**

26

**Maximum**

26

**Unit**

%

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (48)

- A Clinical Trial to Evaluate the Efficacy and Safety of Olmesartan/Amlodipine/Rosuvastatin Combination Treatment in Patients With Concomitant Hypertension and Hyperlipidemia
- A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With Hypertension
- Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy
- An Efficacy and Safety Study of Azilsartan Medoxomil Compared to Valsartan and Olmesartan in Participants With Essential Hypertension.
- Angiotensin Receptor Blocker Combined With Calcium Antagonist Evaluation of Safety and Lowering of Systolic Blood Pressure Study
- Assessment of the Effectiveness of OLMETEC® and OLMETEC PLUS® for Treatment of Hypertension in Stage I and II Patients (Study P05254)(COMPLETED)
- Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance
- Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome
- Clinical Study for Patients With Hypertension Associated With Dyslipidemia
- Clinical Study to Evaluate Adherence Improvement Fixed-dose Combination of Olostar Tab. in Patients With Hypertension and Dyslipidemia
- Clinical Trail to Evaluate the Efficacy and Safety of DWJ1451
- Clinical Trial to Evaluate Pharmacokinetic Interaction of ATB-1011 and ATB-1012 in Healthy Adult Volunteers
- Clinical Trial to Evaluate the Efficacy and Safety of OLOMAX Tab
- Clinical Trial to Investigate the Efficacy and Safety of DWJ1351
- Comparison of Sevikar® and the Combination of Perindopril/Amlodipine on Central Blood Pressure
- Effect of Olmesartan and Nebivolol on Ambulatory Blood Pressure and Arterial Stiffness in Acute Stage of Ischemic Stroke
- Effect of Olmesartan on Angiotensin(1-7) Levels and Vascular Functions in Diabetes and Hypertension
- Effect of olmesaRtan on Walking distancE and quaLIty of lifE in Peripheral Artery Disease Patients With Hypertension Treated For Intermittent Claudication (RELIEF)
- Effects of Antihypertensive Drugs in Patients With Hypertension and Obstructive Sleep Apnea (OSA)
- Efficacy and Safety of a Therapy Change From Candesartan 32 mg to Fixed Combination of Olmesartan 40 mg/Amlodipine 10 mg

### In development for (7)

- [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md) Phase 3
- Cardiac rhythm disease Phase 3
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3
- [Essential hypertension](https://trialight.com/data/condition/essential-hypertension-bd582df2-4596-58b0-aa00-37f10a4759d3.md) Phase 3
- [Hypertensive disorder](https://trialight.com/data/condition/hypertensive-disorder-6d786557-b9e8-5afc-80f3-89a1995f9da5.md) Phase 3
- [Severe acute respiratory syndrome](https://trialight.com/data/condition/severe-acute-respiratory-syndrome-7654d02a-f750-52a0-bec2-afe3b4b3c224.md) Phase 3
- [Stroke disorder](https://trialight.com/data/condition/stroke-disorder-f6ef16d6-34dc-5c87-b764-37f0b5b8d504.md) Phase 2

### Targets (1)

- [AGTR1](https://trialight.com/data/target/agtr1-c59c8e57-b1b7-5c8f-a953-a2b3d70939ed.md) Type-1 angiotensin II receptor antagonist

---

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