> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/oleclumab-139659b0-af92-40b9-87db-3fe0f315881b
> Record changed: 2026-10-13

# Oleclumab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990016)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990016)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990016)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990016)

**Drug name**

Oleclumab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990016)

### Other names (17)

- durvalumab oleclumab
- immunoglobulin g1 anti human 5 nucleotidase human monoclonal medi9447 heavy chain disulfide with human monoclonal medi9447 lambda chain dimer
- IMMUNOGLOBULIN G1, ANTI-(HUMAN 5'-NUCLEOTIDASE) (HUMAN MONOCLONAL MEDI9447 HEAVY CHAIN), DISULFIDE WITH HUMAN MONOCLONAL MEDI9447 .LAMBDA.-CHAIN, DIMER
- medi 9447
- MEDI-9447
- medi9447
- MEDI9447
- MEDI9447 (oleclumab)
- oleclumab
- Oleclumab
- Oleclumab (MEDI9447)
- oleclumab \[INN\]
- OLECLUMAB \[USAN\]
- Oleclumab \[WHO-DD\]
- oleclumab inn
- oleclumab usan
- oleclumab who dd

## Identifiers

**CAS registry numbers**

- 1803176-05-7

**ChEMBL ID**

CHEMBL3990016

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990016)

**FDA ingredient codes (UNII)**

- 5CRY01URYQ

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

oleclumab

**Type**

Antibody

**Drug name stem**

\-mab

### Mechanisms of action (2)

- **Action**  
Binding

**Action type**  
Binding

**Target**  
Ecto-5'-Nucleotidase

**Gene symbol**  
NT5E

**Protein identifier**  
P21589

**Median affinity**

11.38

**Affinity units**  
pKd

**Primary target**  
Yes
- **Mechanism**  
5'-nucleotidase inhibitor

**Action type**  
Inhibitor

**Target**  
5'-nucleotidase

**Protein identifier**  
P21589

### Open Targets mechanisms

- **Mechanism**  
5'-nucleotidase inhibitor

**Action type**  
Inhibitor

**Target**  
5'-nucleotidase

### Investigated indications (11)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003869

**Subject identifier**  
D001943
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001951

**Subject identifier**  
D015179
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0001187

**Subject identifier**  
D001749
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Pancreatic Ductal

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005184

**Subject identifier**  
D021441
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005575

**Subject identifier**  
D015179
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Prostatic Neoplasms, Castration-Resistant

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0008315

**Subject identifier**  
D064129

### Open Targets indications (17)

- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0002618

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004986

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005089

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005184

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005494

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005549

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006047

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0009807

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0010150

**Highest recorded phase**  
2

### Trial references (20)

- NCT02503774  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02503774)
- NCT04261075  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04261075)
- NCT03334617  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03334617)
- NCT03381274  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03381274)
- NCT03794544  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03794544)
- NCT03801902  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03801902)
- NCT03819465  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03819465)
- NCT03822351  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03822351)
- NCT03833440  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03833440)
- NCT05061550  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05061550)
- NCT05221840  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05221840)
- NCT03616886  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03616886)
- NCT03736473  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03736473)
- NCT03742102  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03742102)
- NCT03773666  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03773666)
- NCT04068610  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04068610)
- NCT04089553  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04089553)
- NCT04145193  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04145193)
- NCT04940286  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04940286)
- NCT06060405  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06060405)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (3)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAYSWVRQAPGKGLEWVSAISGSGGRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLGYGRVDEWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
QSVLTQPPSASGTPGQRVTISCSGSLSNIGRNPVNWYQQLPGTAPKLLIYLDNLRLSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSHPGWTFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
- **Component**  
Disulfide bridges location

**Sequence**  
22'-89'$22'''-89'''$22-96$22''-96''$138'-197'$138'''-197'''$144-200$144''-200''$215'-220$215'''-220''$226-226''$ 229-229''$261-321$261''-321''$367-425$367''-425'

## Related records

### Trials (29)

- A Feasibility Study of Durvalumab +/- Oleclumab as Neoadjuvant Therapy for Muscle-invasive Bladder Cancer (BLASST-2)
- [A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer](https://trialight.com/data/trial/a-global-study-to-assess-the-effects-of-durvalumab-with-9b1ffaa8-7388-46c3-8f09-9f534f48bdb9.md)
- A Multi-Cancer, Multi-State, Platform Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Pancreatic Adenocarcinoma, Non-Small Cell Lung Cancer and Squamous Cell Carcinoma of the Head and Neck to Correlate Clinical, Molecular and Immunologic Parameters With DNA Methylation
- A Phase 1 Clinical Study of AZD4635 in Patients With Advanced Solid Malignancies
- A Phase 2 Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Multi-Cancer Populations With Correlation to Clinical, Molecular and Immunologic Parameters With DNA MethylaTION
- A Phase I Study of MEDI9447 (Oleclumab) in Japanese Patients
- A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer
- A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC
- A Study to Investigate the Effects of Durvalumab With Oleclumab Following Chemoradiation in Participants With Locally Advanced Unresectable Non-Small Cell Lung Cancer (LADOGA)
- An Open-label, Phase II Study of AZD4635 in Patients With Prostate Cancer
- COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC
- Durvalumab Alone or in Combination With Novel Agents in Subjects With NSCLC
- Durvalumab and Oleclumab in Resectable PDAC
- Gemcitabine, Nab-paclitaxel, Durvalumab, and Oleclumab Before Surgery for the Treatment of in Resectable/Borderline Resectable Primary Pancreatic Cancer
- IPH5201 as Monotherapy or in Combination With Durvalumab +/- Oleclumab in Subjects With Advanced Solid Tumors.
- MEDI9447 Alone and in Combination With MEDI4736 in Adult Participants With Select Advanced Solid Tumors.
- MEDI9447(Oleclumab) Pancreatic Chemotherapy Combination Study.
- Neo-adjuvant Chemotherapy Combined With Stereotactic Body Radiotherapy to the Primary Tumour +/- Durvalumab, +/- Oleclumab in Luminal B Breast Cancer:
- [Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer](https://trialight.com/data/trial/neoadjuvant-and-adjuvant-treatment-in-resectable-non-small-c5704130-e063-4bfd-817c-edc38351eb37.md)
- Neoadjuvant Durvalumab Alone or in Combination With Novel Agents in Resectable Non-Small Cell Lung Cancer

### In development for (11)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 1
- [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 1
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2
- [Colorectal carcinoma](https://trialight.com/data/condition/colorectal-carcinoma-51401c02-7884-5c5c-bb91-90106e7d0d4a.md) Phase 2
- Exocrine pancreatic carcinoma Phase 2
- Neoplasm Phase 1
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 3
- [Pancreatic ductal adenocarcinoma](https://trialight.com/data/condition/pancreatic-ductal-adenocarcinoma-77c1c5a8-638b-51d0-b18e-2c881b8902e5.md) Phase 2
- [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 2
- Urinary bladder cancer Phase 1

### Targets (1)

- [NT5E](https://trialight.com/data/target/nt5e-260380f3-4e4a-56ba-b945-772d6d406143.md) 5'-nucleotidase inhibitor

---

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