> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/oditrasertib-c75ee3d7-8d17-43fa-80cc-5474ac2cd10b
> Record changed: 2026-10-13

# Oditrasertib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314474)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314474)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314474)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314474)

**Drug name**

Oditrasertib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314474)

**Molecular weight**

295.29

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314474)

**Structure (SMILES)**

CC(C)(C(=O)N1CCOc2c(C#N)cncc2C1)C(F)F

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314474)

### Other names (27)

- c19061501 f
- C19061501-F
- dn 2489
- DN-2489
- dn0002489
- DN0002489
- dn2489
- DN2489
- dnl 788
- DNL-788
- dnl788
- DNL788
- oditrasertib
- Oditrasertib
- oditrasertib \[INN\]
- ODITRASERTIB \[USAN\]
- oditrasertib inn
- oditrasertib usan
- ra 15804589
- RA-15804589
- ra15804589
- RA15804589
- sar 443820
- SAR-443820
- sar443820

And 2 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2252271-93-3

**ChEMBL ID**

CHEMBL5314474

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314474)

**InChIKey**

CSCLQCHKUAMZOY-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314474)

**PubChem compound IDs**

- 135382587

**FDA ingredient codes (UNII)**

- I1YQT8HC89

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

oditrasertib

**Type**

Synthetic organic

**Drug name stem**

\-sertib

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
receptor interacting serine/threonine kinase 1

**Gene symbol**  
RIPK1

**Protein identifier**  
Q13546

**Affinity units**  
pIC50

### Investigated indications (2)

- **Condition**  
Amyotrophic Lateral Sclerosis

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004976

**Subject identifier**  
D000690
- **Condition**  
Multiple Sclerosis

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005301

**Subject identifier**  
D009103

### Open Targets indications (2)

- **Condition identifier**  
MONDO\_0004976

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005301

**Highest recorded phase**  
2

### Trial references (5)

- NCT05237284  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05237284)
- NCT05795907  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05795907)
- NCT05797701  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05797701)
- NCT05797753  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05797753)
- NCT05630547  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05630547)

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

0

**Polar surface area**

66.22

**Calculated partition coefficient (ALogP)**

1.97

**Calculated partition coefficient (XLogP)**

1.3

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

2

**Heavy atoms**

21

**Molecular formula**

C14H15F2N3O2

**Monoisotopic mass**

295.11323305

**Natural product**

No

## Evidence counts

**Recorded assays**

1

**Active assays**

1

### Active assay types

- Confirmatory

## Related records

### Trials (5)

- A Study in Healthy Adult Male & Female Participants to Assess the Amount of the Study Medicine (SAR443820) Absorbed by the Body, When Given Orally in Fasted Condition as a Tablet Versus as a Capsule (Part 1) and When Given Orally as a Tablet in Fasted Condition Versus as a Tablet After Food (Part 2)
- A Study to Assess the Effect of Erythromycin on the Test Medicine (SAR443820) When Given Orally as Tablets to Healthy Adult Male and Female Participants (Part A); and the Effect of Itraconazole on the Test Medicine (SAR443820) When Given Orally as Capsules to Healthy Adult Male Participants (Part B)
- A Study to Evaluate the Effect of SAR443820 on Serum Neurofilament Levels in Male and Female Adult Participants With Multiple Sclerosis
- [Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS)](https://trialight.com/data/trial/phase-2-study-for-sar443820-in-participants-with-amyotrophic-570b7bb1-68b0-4ca0-8e94-beb2a80787af.md)
- Single & Multiple Ascending Dose Study of SAR443820 in Healthy Adult Participants

### In development for (2)

- [Amyotrophic lateral sclerosis](https://trialight.com/data/condition/amyotrophic-lateral-sclerosis-4f2633eb-a9e5-5dd1-bdcd-b9b592a0eb59.md) Phase 2
- [Multiple sclerosis](https://trialight.com/data/condition/multiple-sclerosis-62806c95-fe1b-529e-bd16-95cb92d15375.md) Phase 2

---

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