> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/ociperlimab-d791e6bc-953d-4124-bef4-03973803b3d8
> Record changed: 2026-10-13

# Ociperlimab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650411)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650411)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650411)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650411)

**Drug name**

Ociperlimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650411)

### Other names (21)

- bgb a1217
- Bgb-a1217
- BGB-A1217
- bgba 1217
- BGBA-1217
- bgba1217
- BGBA1217
- immunoglobulin g1 anti human receptor tigit human mus musculus monoclonal bgb a1217 gamma 1 chain disulfide with human mus musculus monoclonal bgb a1217 kappa chain dimer
- immunoglobulin g1 kappa anti homo sapiens tigit t cell immunoreceptor with ig domain and itim v set ig member 9 vsig9 v set and transmembrane member 3 vstm3 humanized monoclonal antibody gamma1 heavy chain humanized 1 449 vh homo sapiens ighv3 66 01 88 8 ighd ighj4 01 100 cdr imgt 8 8 12 26 33 51 58 97 108 1 119 homo sapiens ighg1 01 ng1m1 g1m17 ch1 k120 216 120 217 hinge 1 15 218 232 ch2 233 342 ch3 e12 358 m14 360 343 447 chs 448 449 120 449 222 214 disulfide with kappa light chain humanized 1 214 v kappa homo sapiens igkv3 15 01 87 4 igkj4 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 228 228 231 231 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa
- immunoglobulin g1 kappa anti homo sapiens tigit t cell immunoreceptor with ig domain and itim v set ig member 9 vsig9 v set and transmembrane member 3 vstm3 humanized monoclonal antibody ociperlimab
- IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS TIGIT (T-CELL IMMUNORECEPTOR WITH IG DOMAIN AND ITIM, V-SET IG MEMBER 9, VSIG9, V-SET AND TRANSMEMBRANE MEMBER 3, VSTM3)), HUMANIZED MONOCLONAL ANTIBODY (OCIPERLIMAB)
- IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS TIGIT (T-CELL IMMUNORECEPTOR WITH IG DOMAIN AND ITIM, V-SET IG MEMBER 9, VSIG9, V-SET AND TRANSMEMBRANE MEMBER 3, VSTM3)), HUMANIZED MONOCLONAL ANTIBODY; GAMMA1 HEAVY CHAIN HUMANIZED (1-449) (VH (HOMO SAPIENS IGHV3-66\*01 (88.8%)-(IGHD)-IGHJ4\*01 (100%)) CDR-IMGT (8.8.12) (26-33.51-58.97-108) (1-119)-HOMO SAPIENS IGHG1\*01 NG1M1, G1M17 (CH1 K120 (216) (120-217), HINGE 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)), (222-214')-DISULFIDE WITH KAPPA LIGHT CHAIN HUMANIZED (1'-214') (V-KAPPA (HOMO SAPIENS IGKV3-15\*01 (87.4%)-IGKJ4\*01 (100%)) CDR-IMGT (6.3.9) (27-32.50-52.89-97) (1'-107')-HOMO SAPIENS IGKC\*01 (100%) KM3 A45.1 (153), V101 (191) (108'-214')); DIMER (228-228'':231-231'')-BISDISULFIDE, PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, GLYCOFORM ALFA
- IMMUNOGLOBULIN G1, ANTI-(HUMAN RECEPTOR TIGIT) (HUMAN-MUS MUSCULUS MONOCLONAL BGB-A1217 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL BGB-A1217 .KAPPA.-CHAIN, DIMER
- ociperlimab
- Ociperlimab
- ociperlimab \[INN\]
- OCIPERLIMAB \[USAN\]
- Ociperlimab \[WHO-DD\]
- ociperlimab inn
- ociperlimab usan
- ociperlimab who dd

## Identifiers

**CAS registry numbers**

- 2342597-93-5

**ChEMBL ID**

CHEMBL4650411

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650411)

**FDA ingredient codes (UNII)**

- 7JNY4KV3NK

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Mechanisms of action

- **Mechanism**  
T-cell immunoreceptor with Ig and ITIM domains inhibitor

**Action type**  
Inhibitor

**Target**  
T-cell immunoreceptor with Ig and ITIM domains

**Protein identifier**  
Q495A1

### Open Targets mechanisms

- **Mechanism**  
T-cell immunoreceptor with Ig and ITIM domains inhibitor

**Action type**  
Inhibitor

**Target**  
T-cell immunoreceptor with Ig and ITIM domains

### Investigated indications (9)

- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Esophageal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005922

**Subject identifier**  
D004938
- **Condition**  
Uterine Cervical Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0002974

**Subject identifier**  
D002583
- **Condition**  
Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943

### Open Targets indications (12)

- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0005922

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005580

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007256

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008433

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0018905

**Highest recorded phase**  
1

### Trial references (12)

- NCT04047862  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04047862)
- NCT04164199  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04164199)
- NCT04693234  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04693234)
- NCT04732494  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04732494)
- NCT04746924  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04746924)
- NCT04866017  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04866017)
- NCT05014815  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05014815)
- NCT05791097  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05791097)
- NCT04948697  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04948697)
- NCT04952597  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04952597)
- NCT05267054  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05267054)
- NCT05809895  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05809895)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (5)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
EIVMTQSPATLSVSPGERATLSCKASQDVGTSVAWYQQKPGQAPRLLIYWITKGGGSTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARQTNYDFTMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
EIVMTQSPATLSVSPGERATLSCKASQDVGTSVAWYQQKPGQAPRLLIYWASARHTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYSSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Glycosylation sites (N)

**Sequence**  
299 $ 299''''
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 146-202 $ 146''-202'' $ 214'-202 $ 214'''-202'' $ 228-228'' $ 231-231'' $ 263-323 $ 263''-323'' $ 369-427 $ 369''-427''
- **Component**  
Glycosylation sites (N)

**Sequence**  
299 $ 299''

## Related records

### Trials (13)

- A Study Investigating the Efficacy and Safety of Ociperlimab and Tislelizumab and BAT1706 Combinations in Patients With Advanced HCC
- A Study of Ociperlimab With Tislelizumab Compared to Pembrolizumab in Participants With Untreated Lung Cancer
- A Study to Compare Ociperlimab Plus Tislelizumab Versus Durvalumab Following Concurrent Chemoradiotherapy (cCRT) in Participants With Stage III Unresectable Non-Small Cell Lung Cancer
- AdvanTIG-202: Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) Combined With or Without Anti-TIGIT Monoclonal Antibody Ociperlimab (BGB-A1217) in Participants With Previously Treated Recurrent or Metastatic Cervical Cancer
- Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) Combined With or Without Anti-TIGIT Monoclonal Antibody Ociperlimab (BGB-A1217) in Participants With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma
- Efficacy, Safety, and Pharmacodynamics of Tislelizumab Monotherapy and Multiple Tislelizumab-based Immunotherapy Combinations in Participants With Resectable Non-Small Cell Lung Cancer
- [Ociperlimab With Tislelizumab and Chemotherapy in Participants With Untreated Metastatic Non-Small Cell Lung Cancer](https://trialight.com/data/trial/ociperlimab-with-tislelizumab-and-chemotherapy-in-7c5ce0be-94bc-4300-81e4-bd0002a58b54.md)
- Phase II Study Evaluating the Efficacy and Safety of Ociperlimab in Combination With Tislelizumab and Chemotherapy as First-line Treatment for Participants With Advanced Triple Negative Breast Cancer
- Study of Efficacy and Safety of Ociperlimab in Combination With Tislelizumab and Platinum-based Doublet Chemotherapy as First-line Treatment for Participants With Locally Advanced or Metastatic NSCLC.
- Study of Ociperlimab (BGB-A1217) in Combination With Tislelizumab in Advanced Solid Tumors
- Study of Ociperlimab Plus Tislelizumab Plus Chemoradiotherapy in Participants With Untreated Limited-Stage Small Cell Lung Cancer
- Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies
- Treatment of Relapsed or Refractory Diffuse Large B Cell Lymphoma With Ociperlimab (BGB-A1217) in Combination With Tislelizumab (BGB-A317) or Rituximab

### In development for (9)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 3
- [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 2
- [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 1
- [Esophageal squamous cell carcinoma](https://trialight.com/data/condition/esophageal-squamous-cell-carcinoma-c10bd9c9-02f9-5805-8008-b021f4604e7a.md) Phase 2
- [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) Phase 2
- Neoplasm Phase 3
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 3
- [Small cell lung carcinoma](https://trialight.com/data/condition/small-cell-lung-carcinoma-505ad14d-ce79-5398-b171-f724c32e1b4e.md) Phase 2

### Targets (1)

- [TIGIT](https://trialight.com/data/target/tigit-3420020b-537a-54b3-8cbf-76103a59da64.md) T-cell immunoreceptor with Ig and ITIM domains inhibitor

---

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