> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/nx-5948-b18ade48-dcbc-4741-9d4b-5562859628d5 > Record changed: 2026-10-13 # NX-5948 Highest phase reached Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5558927) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5558927) ## Development status **Listing at source** Listed **Highest phase reached** Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5558927) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5558927) **Drug name** NX-5948 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5558927) **Molecular weight** 806.97 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5558927) **Structure (SMILES)** CN1CCN(\[C@@H\]2CCCN(c3cnc(C(N)=O)c(Nc4ccc(C5CCN(CC6CCN(c7ccc(C(=O)N\[C@H\]8CCC(=O)NC8=O)nc7)CC6)CC5)cc4)n3)C2)C1=O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5558927) ### Other names (13) - bexobrutideg - Bexobrutideg - bexobrutideg \[INN\] - BEXOBRUTIDEG \[USAN\] - bexobrutideg inn - bexobrutideg usan - btk in 24 - BTK-IN-24 - nx 5948 - NX 5948 \[WHO-DD\] - nx 5948 who dd - Nx-5948 - NX-5948 ## Identifiers **CAS registry numbers** - 2649400-34-8 **ChEMBL ID** CHEMBL5558927 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5558927) **InChIKey** HPTPDBYCFHFWJG-CWTKIQHKSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5558927) **PubChem compound IDs** - 156464216 **FDA ingredient codes (UNII)** - HVD6HGW6JD ## Regulatory information ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Pharmacology name** bexobrutideg **Type** Synthetic organic ### Open Targets indications (10) - **Condition identifier** EFO\_0000095 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005952 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0002571 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004948 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0017604 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0018876 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0018905 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0018906 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0018908 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0100280 **Highest recorded phase** 1 ## Chemical properties **Hydrogen bond acceptors** 12 **Hydrogen bond donors** 4 **Polar surface area** 202.33 **Calculated partition coefficient (ALogP)** 2.68 **Calculated partition coefficient (XLogP)** 2.6 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 2 **Rotatable bonds** 11 **Heavy atoms** 59 **Molecular formula** C42H54N12O5 **Monoisotopic mass** 806.43401287 **Natural product** No ## Evidence counts **Recorded assays** 25 **Active assays** 2 ### Active assay types - Confirmatory ## Biological measurements These details could not be displayed. ## Related records ### Trials (6) - [A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers](https://trialight.com/data/trial/a-single-and-multiple-ascending-doses-relative-e765be29-f034-4382-84c2-075c49a7d226.md) - A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201) - [A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies](https://trialight.com/data/trial/a-study-of-nx-5948-in-adults-with-relapsed-refractory-b-cell-e6f19e49-bdcf-4d6f-9c0f-10ecf9076e2a.md) - Absolute Bioavailability, Absorption, Metabolism, Excretion, and Mass Balance Study of \[14C\] NX-5948 - Study of NX-5948 in Combination With Other Agents in Adults With B-cell Malignancies - Study of NX-5948 Versus Pirtobrutinib in R/R CLL/SLL ### In development for (2) - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 2 - [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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