NV-5138
Highest phase reached
Phase 2
Drug type
Small molecule
- Listing at source
- Listed
- Highest phase reached
- Phase 2
- Drug type
- Small molecule
- Drug name
- NV-5138
- Molecular weight
- 181.18
- Structure (SMILES)
- CC(C)(C[C@H](N)C(=O)O)C(F)F
- mefluleucine
- Mefluleucine
- mefluleucine [INN]
- mefluleucine inn
- nv 5138
- Nv-5138
- NV-5138
- nv5138
- NV5138
- pentanoic acid 2 amino 5 5 difluoro 4 4 dimethyl 2s
- PENTANOIC ACID, 2-AMINO-5,5-DIFLUORO-4,4-DIMETHYL-, (2S)-
- CAS registry numbers
- 2095886-80-7
- ChEMBL ID
- CHEMBL4650303
- InChIKey
- HRFIMCJTDKEPPV-BYPYZUCNSA-N
- PubChem compound IDs
- 129050791
- FDA ingredient codes (UNII)
- 06CA9QMG6Z
- First in class
- No
- Orphan designation
- No
- Condition
- Depressive Disorder, Treatment-Resistant
- Highest recorded phase
- 2
- Condition identifier
- EFO:0009854
- Subject identifier
- D061218
- Condition
- Depressive Disorder, Major
- Highest recorded phase
- 2
- Condition identifier
- MONDO:0002009
- Subject identifier
- D003865
- Condition identifier
- EFO_0009854
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0002009
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0002050
- Highest recorded phase
- 1
- NCT03606395
- NCT05066672
- NCT06235905
- Hydrogen bond acceptors
- 2
- Hydrogen bond donors
- 2
- Polar surface area
- 63.32
- Calculated partition coefficient (ALogP)
- 1.08
- Calculated partition coefficient (XLogP)
- -1
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Rule-of-five violations
- 0
- Rotatable bonds
- 4
- Heavy atoms
- 12
- Molecular formula
- C7H13F2NO2
- Monoisotopic mass
- 181.09143498
- Natural product
- No
Related records
Trials (5)
- Mass Balance Study of NV-5138 in Healthy Male Subjects
- Mass Balance Study of NV-5138 in Healthy Male Subjects.
- Open-Label of SPN-820 in Adults With Major Depressive Disorder
- Phase 2 Study of NV-5138 in Adults With Treatment Resistant Depression
- Safety, Tolerability, PK and Efficacy of Single Doses of NV-5138 in Healthy Volunteers and Subjects With Treatment-Resistant Depression
In development for (2)
- Depressive disorder Phase 1
- Major depressive disorder Phase 2