Nurandociguat
Highest phase reached
Phase 2
Drug type
Small molecule
- Listing at source
- Listed
- Highest phase reached
- Phase 2
- Drug type
- Small molecule
- Drug name
- Nurandociguat
- Molecular weight
- 572.1
- Structure (SMILES)
- CC(C)CN1CCN(c2ccc(-c3ccc(Cl)cc3N3CCC[C@@H](n4ncc(C(=O)O)c4C(F)F)C3)cc2)CC1
- bay 3283142
- BAY-3283142
- bay3283142
- BAY3283142
- nurandociguat
- Nurandociguat
- Nurandociguat (BAY3283142) new tablet
- Nurandociguat (BAY3283142) new tablet - SD
- Nurandociguat (BAY3283142) old tablet
- Nurandociguat (BAY3283142) old tablet - SD
- nurandociguat [INN]
- NURANDOCIGUAT [USAN]
- nurandociguat inn
- nurandociguat usan
- CAS registry numbers
- 2781965-75-9
- ChEMBL ID
- CHEMBL6068024
- InChIKey
- KNGOFJLMZYHAGD-XMMPIXPASA-N
- PubChem compound IDs
- 163396665
- FDA ingredient codes (UNII)
- LPU8429UK5
- First in class
- No
- Orphan designation
- No
- Drug name stem
- -ciguat
Open Targets indications
- Condition identifier
- MONDO_0005010
- Highest recorded phase
- 1
- Hydrogen bond acceptors
- 6
- Hydrogen bond donors
- 1
- Polar surface area
- 64.84
- Calculated partition coefficient (ALogP)
- 6.46
- Calculated partition coefficient (XLogP)
- 3.9
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Rule-of-five violations
- 2
- Rotatable bonds
- 8
- Heavy atoms
- 40
- Molecular formula
- C30H36ClF2N5O2
- Monoisotopic mass
- 571.2525594
- Natural product
- No
Related records
Trials (9)
- A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
- A Study to Learn About How a New Nurandociguat Tablet is Absorbed and Processed in the Body Compared to an Old Tablet and How Food Affects the Way the New Tablet is Absorbed and Processed in the Body
- A Study to Learn About How BAY 3283142 Moves Into, Through, and Out of the Body After a Single Dose in Participants With Reduced Liver Function Compared to Participants With Normal Liver Function
- A Study to Learn About How Safe Nitroglycerin is and How it Affects the Body When Taken Along With Nurandociguat in People With Coronary Artery Disease
- A Study to Learn About How Well BAY3283142 Works and Its Safety in Participants With Chronic Kidney Disease
- A Study to Learn About the Safety of BAY3283142 in People With Mild to Moderate High Blood Pressure
- A Study to Learn How Safe BAY3283142 is When Taken as a Single Dose or as Multiple Doses in Healthy Chinese Participants
- A Study to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body, How it Moves Into, Through and Out of the Body When Single and Multiple Amounts Are Taken as Tablets in Japanese Healthy Male Participants
- A Study to Learn More About How Safe Nurandociguat is and How it Affects the Way the Body Processes Rosuvastatin and Dabigatran in Healthy Adults