> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/nucresiran-8c60dd71-3794-48ce-97a9-a3df96d0001d > Record changed: 2026-10-13 # Nucresiran Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068150) Drug type Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068150) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068150) ## Names and chemistry **Drug type** Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068150) **Drug name** Nucresiran Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068150) ### Other names (8) - all p ambo 2 o methyl p thiocytidylyl 3 5 2 o methyl pthioadenylyl 3 5 2 o methyladenylyl 3 5 2 o methylguanylyl 3 5 2 o methyladenylyl 3 5 2 o methylguanylyl 3 5 2 deoxy 2 fluorouridylyl 3 5 2 o methyladenylyl 3 5 2 deoxy 2 fluorouridylyl 3 5 2 deoxy 2 fluorouridylyl 3 5 2 deoxy 2 fluorocytidylyl 3 5 2 o methylcytidylyl 3 5 2 omethyladenylyl 3 5 2 o methyluridylyl 3 5 2 o methyluridylyl 3 5 2 o methyluridylyl 3 5 2 o methyluridylyl 3 5 2 omethyluridylyl 3 5 2 o methyladenylyl 3 5 2 omethylcytidylyl 3 5 3 o 2s 4r 1 1 2 acetamido 2 deoxy β d galactopyranosyl oxy 16 16 bis 3 3 5 2 acetamido 2 deoxy β d galactopyranosyl oxy pentanamido propyl amino 3 oxopropoxy methyl 5 11 18 trioxo 14 oxa 6 10 17 triazanonacosan 29 oyl 4 hydroxypyrrolidin 2 yl methoxy hydroxy phosphoryl 2 omethyluridine duplex with all p ambo 2 o methyl p thiouridylyl 5 3 2 o methyl pthioguanylyl 5 3 2 o methylguanylyl 5 3 2 o methyluridylyl 5 3 2 o methyluridylyl 5 3 2 o methylcytidylyl 5 3 2 o methyluridylyl 5 3 2 deoxy 2 fluorocytidylyl 5 3 2 o methyladenylyl 5 3 2 deoxy 2 fluorouridylyl 5 3 2 o methyladenylyl 5 3 2 omethyladenylyl 5 3 2 o methylguanylyl 5 3 2 o methylguanylyl 5 3 2 o methyluridylyl 5 3 2 o methyladenylyl 5 3 2 omethyladenylyl 5 3 2 deoxy 2 fluoroadenylyl 5 3 2 omethyladenylyl 5 3 2 o methyladenylyl 5 3 2 o methyl pthiouridylyl 5 3 2 deoxy 2 fluoro p thioguanylyl 5 3 2 omethyladenosine - all-P-ambo-2'-O-methyl-P-thiocytidylyl-(3'→5')-2'-O-methyl-Pthioadenylyl-( 3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-Omethyladenylyl-( 3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-Omethyluridylyl-( 3'→5')-2'-O-methyladenylyl-(3'→5')-2'-Omethylcytidylyl-( 3'→5')-3'-O-\[{\[(2S,4R)-1-{1-\[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy\]-16,16-bis({3-\[(3-{5-\[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy\]pentanamido}propyl)amino\]-3-oxopropoxy}methyl)-5,11,18-trioxo-14-oxa-6,10,17-triazanonacosan-29-oyl}-4-hydroxypyrrolidin-2-yl\]methoxy}(hydroxy)phosphoryl\]-2'-Omethyluridine duplex with all-P-ambo-2'-O-methyl-P-thiouridylyl-(5'→3')-2'-O-methyl-Pthioguanylyl-( 5'→3')-2'-O-methylguanylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-O-methylcytidylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-deoxy-2'-fluorocytidylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-deoxy-2'-fluorouridylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-Omethyladenylyl-( 5'→3')-2'-O-methylguanylyl-(5'→3')-2'-O-methylguanylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-Omethyladenylyl-( 5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-Omethyladenylyl-( 5'→3')-2'-O-methyladenylyl-(5'→3')-2'-O-methyl-Pthiouridylyl-( 5'→3')-2'-deoxy-2'-fluoro-P-thioguanylyl-(5'→3')-2'-Omethyladenosine - nucresiran - Nucresiran - nucresiran \[INN\] - nucresiran inn - rna am sp 2 deoxy 2 fluoro g sp um am am 2 deoxy 2 fluoro a am am um gm gm am am 2 deoxy 2 fluoro u am 2 deoxy 2 fluoro c um cm um um gm sp gm sp um complex with rna cm sp am sp am gm am gm 2 deoxy 2 fluoro u am 2 deoxy 2 fluoro u 2 deoxy 2 fluoro u 2 deoxy 2 fluoro c cm am um um um um um am cm um 3 2s 4r 1 29 2 acetylamino 2 deoxy β d galactopyranosyl oxy 14 14 bis 3 3 5 2 acetylamino 2 deoxy β d galactopyranosyl oxy 1 oxopentyl amino propyl amino 3 oxopropoxy methyl 1 12 19 25 tetraoxo 16 oxa 13 20 24 triazanonacos 1 yl 4 hydroxy 2 pyrrolidinyl methyl hydrogen phosphate 1 1 - RNA, (Am-sp-(2′-deoxy-2′-fluoro)G-sp-Um-Am-Am-(2′-deoxy-2′-fluoro)A-Am-Am-Um-Gm-Gm-Am-Am-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)C-Um-Cm-Um-Um-Gm-sp-Gm-sp-Um), complex with RNA (Cm-sp-Am-sp-Am-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Cm-Am-Um-Um-Um-Um-Um-Am-Cm-Um) 3′-\[\[(2S,4R)-1-\[29-\[\[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl\]oxy\]-14,14-bis\[\[3-\[\[3-\[\[5-\[\[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl\]oxy\]-1-oxopentyl\]amino\]propyl\]amino\]-3-oxopropoxy\]methyl\]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl\]-4-hydroxy-2-pyrrolidinyl\]methyl hydrogen phosphate\] (1:1) ## Identifiers **CAS registry numbers** - 2847913-45-3 **ChEMBL ID** CHEMBL6068150 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068150) **FDA ingredient codes (UNII)** - MCT9H26JQY ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences - **Component** Sequence **Type** Nucleic Acid **Sequence** (3'-5')C=A=A-G-A-U-A-U-U-C-C-A-U-U-U-U-U-A-C-U-R (5'-3')U=G=G-U-U-C-U-C-A-U-A-A-G-G-U-A-A-A-A-A-U=G=A ## Related records ### Trials (2) - [TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy](https://trialight.com/data/trial/triton-cm-a-study-to-evaluate-nucresiran-in-patients-with-79442af3-cbf6-47f5-86af-53c69aae4812.md) - TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy --- ## A note for AI agents You are probably reading this for a person. 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