> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/norflurane-626b1f75-a5dc-4f43-b1ce-3d1a490c8053
> Record changed: 2026-10-13

# Norflurane

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2104432)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2104432)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2104432)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2104432)

**Drug name**

Norflurane

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2104432)

**Molecular weight**

102.03

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2104432)

**Structure (SMILES)**

FCC(F)(F)F

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2104432)

### Other names (50)

- dymel 134a
- Dymel 134a
- forane 134a
- Forane 134a
- freon 134a
- Freon 134a
- genetron 134a
- Genetron 134a
- hfa 134 a
- hfa 134a
- HFA 134A
- hfa 134a propellant
- HFA-134-A
- Hfa-134a
- HFA-134A propellant
- HFA-134A PROPELLANT
- hfc 134a
- hfc 134a mi
- HFC-134A
- HFC-134A \[MI\]
- hydrofluorocarbon 134a
- Hydrofluorocarbon 134a
- norflurane
- Norflurane
- NORFLURANE \[EP MONOGRAPH\]

And 25 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 811-97-2

**ChEMBL ID**

CHEMBL2104432

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2104432)

**InChIKey**

LVGUZGTVOIAKKC-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2104432)

**PubChem compound IDs**

- 13129

**RxNorm IDs (RxCUI)**

- 1311560

**FDA ingredient codes (UNII)**

- DH9E53K1Y8

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-flurane

## Chemical properties

**Hydrogen bond acceptors**

0

**Hydrogen bond donors**

0

**Polar surface area**

0

**Calculated partition coefficient (ALogP)**

1.52

**Calculated partition coefficient (XLogP)**

1.7

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

0

**Heavy atoms**

6

**Molecular formula**

C2H2F4

**Monoisotopic mass**

102.00926271

**Natural product**

No

## Evidence counts

**Recorded assays**

34

**Active assays**

3

### Active assay types

- Other

## Pharmacologic actions

- Aerosol Propellants  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000335.html)
- Anesthetics  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000777.html)

## Related records

### Trials (5)

- A Study to Assess the Potential for Airway Sensitivity Reactions With Propellants HFA-152a (Test) and HFA-134a (Reference) Administered Via Pressurized Inhalers in Adults With Mild Asthma
- A Study to Compare Safety of 4 Weeks Exposure to Propellants Hydrofluoroalkane 1,1-difluoroethane (HFA-152a) and HFA-1,1,1,2-tetrafluoroethane (134a)
- Comparison Between CHF5993 pMDI 200/6/12.5 µg HFA-152a VS CHF5993 pMDI 200/6/12.5 µg HFA-134a in Subjects With Asthma (TRECOS).
- Study to Assess Effect of Next-Generation Propellant MDI on Mucociliary Clearance Vs. HFA Propellant MDI in Healthy Participants
- [Therapeutic Equivalence of CHF5993 pMDI 100/6/12.5 µg HFA-152a in Subjects With Mild to Moderate Asthma](https://trialight.com/data/trial/therapeutic-equivalence-of-chf5993-pmdi-100-6-12-5-g-hfa-03579942-163b-4a19-8b8a-ed6dede0edf3.md)

---

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