Nomifensine maleate
Highest phase reached
Approved
Drug type
Small molecule
First approval year
1984
- First approval year
- 1984
- Listing at source
- Listed
- Highest phase reached
- Approved
- Drug type
- Small molecule
- Drug name
- Nomifensine maleate
- Molecular weight
- 354.41
- Structure (SMILES)
- CN1Cc2c(N)cccc2C(c2ccccc2)C1.O=C(O)/C=C\C(=O)O
- Alival (antidepressant)
- alival antidepressant
- merital
- Merital
- (±)-NOMIFENSINE HYDROGEN MALEATE
- antidepressant
- Antidepressant
- hoe 984
- HOE 984
- HOE-984
- hostalival
- Hostalival
- nomifensine hydrogen maleate
- Nomifensine hydrogen maleate
- nomifensine maleate
- Nomifensine maleate
- NOMIFENSINE MALEATE [MART.]
- NOMIFENSINE MALEATE [MI]
- NOMIFENSINE MALEATE [USAN]
- Nomifensine maleate [WHO-DD]
- nomifensine maleate mart
- nomifensine maleate mi
- nomifensine maleate usan
- nomifensine maleate who dd
- nsc 289114
- NSC-289114
- psicronizer
- Psicronizer
- CAS registry numbers
- 32795-47-4
- ChEMBL ID
- CHEMBL1256842
- InChIKey
- GEOCVSMCLVIOEV-BTJKTKAUSA-N
- RxNorm IDs (RxCUI)
- 262302
- FDA ingredient codes (UNII)
- 76S8CUH5MR
- 5358907
- 6434118
- First in class
- No
- Orphan designation
- No
- Availability
- Withdrawn
- Drug name stem
- -fensine
- Mechanism
- Monoamine transporter inhibitor
- Action type
- Inhibitor
- Target
- Monoamine transporter
- Protein identifier
- P23975
- Mechanism
- Monoamine transporter inhibitor
- Action type
- Inhibitor
- Target
- Monoamine transporter
- Protein identifier
- P31645
- Mechanism
- Monoamine transporter inhibitor
- Action type
- Inhibitor
- Target
- Monoamine transporter
- Protein identifier
- Q01959
Open Targets mechanisms
- Mechanism
- Monoamine transporter inhibitor
- Action type
- Inhibitor
- Target
- Monoamine transporter
- Condition identifier
- MONDO_0002009
- Highest recorded phase
- 4
- Condition identifier
- MONDO_0007254
- Highest recorded phase
- 4
- Warning
- Withdrawn
- Effect
- hematological toxicity
- Description
- increased incidence of hemolytic anemia
- Year
- 1986
- Warning
- Withdrawn
- Effect
- hematological toxicity
- Description
- rare cases of haemolytic anaemia - sometimes fatal - thrombocytopenia, hepatotoxicity
- Year
- 1986
- Warning
- Withdrawn
- Effect
- hematological toxicity
- Description
- Serious hypersensitive reactions; Hemolytic Anemia; Hepatotoxicity
- Year
- 1986
- Warning
- Withdrawn
- Effect
- hepatotoxicity
- Description
- rare cases of haemolytic anaemia - sometimes fatal - thrombocytopenia, hepatotoxicity
- Year
- 1986
- Warning
- Withdrawn
- Effect
- hepatotoxicity
- Description
- Serious hypersensitive reactions; Hemolytic Anemia; Hepatotoxicity
- Year
- 1986
- Warning
- Withdrawn
- Effect
- immune system toxicity
- Description
- Serious hypersensitive reactions; Hemolytic Anemia; Hepatotoxicity
- Year
- 1986
- Warning
- Withdrawn
- Effect
- hematological toxicity
- Description
- increased incidence of hemolytic anemia
- Year
- 1986
- Country
- Worldwide
- Condition
- hemolytic anemia
- Warning
- Withdrawn
- Effect
- hematological toxicity
- Description
- rare cases of haemolytic anaemia - sometimes fatal - thrombocytopenia, hepatotoxicity
- Year
- 1986
- Country
- Worldwide
- Condition
- hemolytic anemia
- Warning
- Withdrawn
- Effect
- hematological toxicity
- Description
- rare cases of haemolytic anaemia - sometimes fatal - thrombocytopenia, hepatotoxicity
- Year
- 1986
- Country
- Worldwide
- Condition
- Thrombocytopenia
- Warning
- Withdrawn
- Effect
- hematological toxicity
- Description
- Serious hypersensitive reactions; Hemolytic Anemia; Hepatotoxicity
- Year
- 1986
- Country
- Worldwide
- Condition
- hemolytic anemia
- Warning
- Withdrawn
- Effect
- hepatotoxicity
- Description
- rare cases of haemolytic anaemia - sometimes fatal - thrombocytopenia, hepatotoxicity
- Year
- 1986
- Country
- Worldwide
- Condition
- drug-induced liver injury
- Warning
- Withdrawn
- Effect
- hepatotoxicity
- Description
- rare cases of haemolytic anaemia - sometimes fatal - thrombocytopenia, hepatotoxicity
- Year
- 1986
- Country
- Worldwide
- Condition
- hepatotoxicity
- Warning
- Withdrawn
- Effect
- hepatotoxicity
- Description
- Serious hypersensitive reactions; Hemolytic Anemia; Hepatotoxicity
- Year
- 1986
- Country
- Worldwide
- Condition
- drug-induced liver injury
- Warning
- Withdrawn
- Effect
- hepatotoxicity
- Description
- Serious hypersensitive reactions; Hemolytic Anemia; Hepatotoxicity
- Year
- 1986
- Country
- Worldwide
- Condition
- hepatotoxicity
- Warning
- Withdrawn
- Effect
- immune system toxicity
- Description
- Serious hypersensitive reactions; Hemolytic Anemia; Hepatotoxicity
- Year
- 1986
- Country
- Worldwide
- Condition
- hypersensitivity reaction disease
- Hydrogen bond acceptors
- 2
- Hydrogen bond donors
- 1
- Polar surface area
- 29.26
- Calculated partition coefficient (ALogP)
- 2.85
- Prodrug
- No
- Chirality
- Racemic
- Inorganic
- No
- Rule-of-five violations
- 0
- Rotatable bonds
- 1
- Heavy atoms
- 26
- Molecular formula
- C20H22N2O4
- Monoisotopic mass
- 354.15795719
- Natural product
- No
- Recorded assays
- 1,788
- Active assays
- 41
- Confirmatory
- Other
- Screening
- Dopamine Uptake Inhibitors
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