> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/nomegestrol-acetate-2dc212bb-4e53-49f4-acd2-2f2cd1a6169a
> Record changed: 2026-10-13

# Nomegestrol acetate

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1476022)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1476022)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1476022)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1476022)

**Drug name**

Nomegestrol acetate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1476022)

**Molecular weight**

370.49

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1476022)

**Structure (SMILES)**

CC(=O)O\[C@\]1(C(C)=O)CC\[C@H\]2\[C@@H\]3C=C(C)C4=CC(=O)CC\[C@@H\]4\[C@H\]3CC\[C@@\]21C

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1476022)

### Brand names (2)

- ioa
- Ioa

### Other names (27)

- 17 acetoxy 6 methyl 19 norpregn 4 6 dien 3 20 dione
- 17-ACETOXY-6-METHYL-19-NORPREGN-4,6-DIEN-3,20-DIONE
- 19 norpregna 4 6 diene 3 20 dione 17 acetyloxy 6 methyl
- 19-NORPREGNA-4,6-DIENE-3,20-DIONE, 17-(ACETYLOXY)-6-METHYL-
- 6 methyl 3 20 dioxo 19 norpregna 4 6 dien 17 yl acetate
- 6-Methyl-3,20-dioxo-19-norpregna-4,6-dien-17-yl acetate
- nomac
- Nomac
- NOMAC
- nomegestrol acetate
- Nomegestrol acetate
- NOMEGESTROL ACETATE \[EP MONOGRAPH\]
- NOMEGESTROL ACETATE \[MART.\]
- NOMEGESTROL ACETATE \[USAN\]
- Nomegestrol acetate \[WHO-DD\]
- nomegestrol acetate ep monograph
- nomegestrol acetate mart
- nomegestrol acetate usan
- nomegestrol acetate who dd
- org 10486 0
- ORG 10486-0
- ORG-10486-0
- tx 066
- TX 066
- TX-066

And 2 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- G03DB04

Sources for recorded values

Source: [mor.nlm.nih.gov](https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=31930)

**CAS registry numbers**

- 58652-20-3

**ChEMBL ID**

CHEMBL1476022

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1476022)

**InChIKey**

IIVBFTNIGYRNQY-YQLZSBIMSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1476022)

**PubChem compound IDs**

- 91668

**FDA ingredient codes (UNII)**

- 83J78V5W05

### RxNorm IDs (RxCUI) (2)

- 31930
- 53744

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-estr-; -gest-

### Mechanisms of action

- **Mechanism**  
Progesterone receptor agonist

**Action type**  
Agonist

**Target**  
Progesterone receptor

**Protein identifier**  
P06401

### Open Targets mechanisms

- **Mechanism**  
Progesterone receptor agonist

**Action type**  
Agonist

**Target**  
Progesterone receptor

### Investigated indications (4)

- **Condition**  
Polycystic Ovary Syndrome

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000660

**Subject identifier**  
D011085
- **Condition**  
Menopause

**Highest recorded phase**  
1

**Condition identifier**  
GO:0042697

**Subject identifier**  
D008593
- **Condition**  
Dysmenorrhea

**Highest recorded phase**  
2

**Condition identifier**  
HP:0100607

**Subject identifier**  
D004412
- **Condition**  
Multiple Sclerosis

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0005301

**Subject identifier**  
D009103

### Open Targets indications (10)

- **Condition identifier**  
EFO\_0000660

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0009520

**Highest recorded phase**  
4
- **Condition identifier**  
GO\_0030728

**Highest recorded phase**  
2
- **Condition identifier**  
GO\_0042697

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0100607

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005301

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0007254
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0008487

**Highest recorded phase**  
1

### Reported adverse events (12)

- **Event**  
amenorrhoea

**Reports**  
3

**Reporting signal score**

11.4932
- **Event**  
dysmenorrhoea

**Reports**  
2

**Reporting signal score**

8.6086
- **Event**  
exposure keratitis

**Reports**  
1

**Reporting signal score**

9.6027
- **Event**  
hyperprolactinaemia

**Reports**  
2

**Reporting signal score**

8.77761
- **Event**  
hypomenorrhoea

**Reports**  
3

**Reporting signal score**

18.2999
- **Event**  
meningioma

**Reports**  
3

**Reporting signal score**

14.8508
- **Event**  
meningioma surgery

**Reports**  
1

**Reporting signal score**

8.4241
- **Event**  
peripheral swelling

**Reports**  
4

**Reporting signal score**

7.58774
- **Event**  
pregnancy on oral contraceptive

**Reports**  
2

**Reporting signal score**

11.1762
- **Event**  
thrombosis

**Reports**  
6

**Reporting signal score**

17.2429
- **Event**  
tracheal pain

**Reports**  
1

**Reporting signal score**

7.6144
- **Event**  
xith nerve injury

**Reports**  
1

**Reporting signal score**

10.2958

### Trial references (4)

- NCT00127075  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00127075)
- NCT01345786  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01345786)
- NCT01603745  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01603745)
- NCT01670656  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01670656)

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

0

**Polar surface area**

60.44

**Calculated partition coefficient (ALogP)**

4.19

**Calculated partition coefficient (XLogP)**

2.6

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

2

**Heavy atoms**

27

**Molecular formula**

C23H30O4

**Monoisotopic mass**

370.21440943

**Natural product**

Yes

## Evidence counts

**Recorded assays**

608

**Active assays**

9

### Active assay types (2)

- Confirmatory
- Screening

## Related records

### Trials (20)

- A Dose-Finding Study to Evaluate Ovarian Function and Vaginal Bleeding in Next Generation Rings (P06109/MK-8175A/MK-8342B-012)
- A Study to Evaluate the Effect of Contraceptive Vaginal Rings on Primary Dysmenorrhea (P08257/MK-8175A/MK-8342B-057)
- A Trial to Assess the Pharmacokinetic Profile (e.g., Uptake, Distribution and Excretion of a Substance in the Body) of Nomegestrol Acetate (NOMAC), Estradiol (E2) and Estrone (E1) After Multiple and Single Dose Administration of the Combined Oral Contraception NOMAC-E2 (COMPLETED)(P05822)
- Bioequivalence of Nomegestrol Acetate (NOMAC) and Estradiol (E2) in Commercial Versus Phase 3 Pivotal Clinical Batches of NOMAC-E2 Tablets (P06328)
- Comparison of Coagulation Profiles Between Zoely and Minidoz: RCT
- [Contraceptive Efficacy and Safety of NOMAC-E2 Combined Oral Contraceptive](https://trialight.com/data/trial/contraceptive-efficacy-and-safety-of-nomac-e2-combined-oral-3608af25-8fcd-490b-b7a8-24ba26e103ca.md)
- Effects of Drospirenone-ethinylestradiol and/or NOMAC-valerate Estradiol on Cardiovascular Risk in Women With Polycystic Ovary Syndrome
- Effects on Bone Mineral Density (BMD) of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG/EE (292005)(P05765)(COMPLETED)
- Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764)
- Effects on Ovarian Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing DRSP/EE (292003)(COMPLETED)(P05723)
- Efficacy and Safety of Oral NOMAC-E2 in Indian Women (P07057/MK-8175A-017)
- Efficacy and Safety of the Combined Oral Contraceptive (COC) NOMAC-E2 Compared to a COC Containing DRSP/EE (292001)(COMPLETED)(P05724)
- Efficacy and Safety Study of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing DRSP/EE (292002)(P05722)
- Minimal Effective Dose of Nomegestrol Acetate Inhibiting the Ovulation in Women Receiving Estradiol
- Ovulation and Follicular Development Associated With Mid Follicular Phase Initiation of Combined Hormonal Contraception
- POPART'MUS: Prevention of Post Partum Relapses With Progestin and Estradiol in Multiple Sclerosis
- Study of the Contraceptive Efficacy and Safety of a NOMAC-E2 Combined Oral Contraceptive (COC)(P06448)
- The Use of Drospirenone/Estetrol, Nomegestrol Acetate/Estradiol and Ethinylestradiol/Dienogest in Random Start Rapid Endometrial Preparation
- The Use of Nomegestrol Acetate/Estradiol in Random Start Rapid Endometrial Preparation
- Thorough QT/QTc Study of Multiple Oral Doses of NOMAC-E2 (Org 10486 0 + Org 2317) in Healthy Women (Study 292011)(P05802)

### In development for (3)

- Dysmenorrhea Phase 2
- [Multiple sclerosis](https://trialight.com/data/condition/multiple-sclerosis-62806c95-fe1b-529e-bd16-95cb92d15375.md) Phase 3
- Polycystic ovary syndrome Phase 1

### Other linked conditions (1)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md)

### Targets (1)

- [PGR](https://trialight.com/data/target/pgr-4e536b31-8799-5ace-a427-be36fd8a5f9f.md) Progesterone receptor agonist

---

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