> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/nivisnebart-24826803-d482-4174-b52d-6636b4a1c6d3 > Record changed: 2026-10-13 # Nivisnebart Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068272) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068272) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068272) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068272) **Drug name** Nivisnebart Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068272) ### Other names (20) - al 101 - AL 101 - gsk 4527226 - GSK-4527226 - gsk4527226 - GSK4527226 - h gamma1 heavy chain homo sapiens 1 459 vh homo sapiens ighv1 46 01 96 9 ighd ighj6 01 94 1 cdr imgt 8 8 22 26 33 51 58 97 118 1 129 homo sapiens ighg1 01 g1m17 1 ch1 k120 ch3 d12 l14 g1v40 ch2 a1 3 a1 2 s116 ch1 k120 226 130 227 hinge 1 15 228 242 ch2 l1 3 a 246 l1 2 a 247 p116 s 343 243 352 ch3 d12 368 l14 370 353 457 chs 458 459 130 459 232 214 disulfide with l kappa light chain homo sapiens 1 214 v kappa homo sapiens igkv3 15 01 100 igkj4 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 v101 c kappa a45 1 153 v101 191 108 214 dimer 238 238 241 241 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa - H-gamma1 heavy chain Homo sapiens (1-459) \[VH (Homo sapiens IGHV1-46\*01 (96.9%) -(IGHD) -IGHJ6\*01 (94.1%), CDR-IMGT \[8.8.22\] (26-33.51-58.97-118)) (1-129) -Homo sapiens IGHG1\*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v40 CH2 A1.3, A1.2, S116 (CH1 K120 (226) (130-227), hinge 1-15 (228-242), CH2 L1.3>A (246), L1.2>A (247), P116>S (343) (243-352), CH3 D12 (368), L14 (370) (353-457), CHS (458-459)) (130-459)\], (232-214')-disulfide with L-kappa light chain Homo sapiens (1'-214') \[V-KAPPA (Homo sapiens IGKV3-15\*01 (100%) -IGKJ4\*01 (100%), CDR-IMGT \[6.3.9\] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC\*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')\]; dimer (238-238'':241-241'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa - Immunoglobulin G1 \[246-alanine,247-alanine,343-serine\], anti-(human sortilin) (recombinant human monoclonal S-15-10-7 allotype G1m17(1) γ1-chain), disulfide with recombinant human monoclonal S-15-10-7 κ-chain, dimer - immunoglobulin g1 246 alanine 247 alanine 343 serine anti human sortilin recombinant human monoclonal s 15 10 7 allotype g1m17 1 γ1 chain disulfide with recombinant human monoclonal s 15 10 7 κ chain dimer - immunoglobulin g1 kappa anti homo sapiens sort1 sortilin 1 gp95 nt3 homo sapiens monoclonal antibody - immunoglobulin G1-kappa, anti-\[Homo sapiens SORT1 (sortilin 1, Gp95, NT3)\], Homo sapiens monoclonal antibody; - nivisnebart - Nivisnebart - nivisnebart \[INN\] - NIVISNEBART \[USAN\] - nivisnebart inn - nivisnebart usan - s15 10 7 - S15-10-7 ## Identifiers **CAS registry numbers** - 2923556-87-8 **ChEMBL ID** CHEMBL6068272 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068272) **FDA ingredient codes (UNII)** - YRU8TD2FZD ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** nivisnebart **Type** Antibody **Drug name stem** \-bart ### Mechanisms of action - **Action** Antagonist **Action type** Antagonist **Target** sortilin 1 **Gene symbol** SORT1 **Protein identifier** Q99523 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Light chain **Type** Protein **Sequence** EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGRAPRLLIYGASTRATGIPARESGSGSGTEETLTISSLQSEDEAVYYCQQARLGPWTEGGGTKVEIKRTVAAPSVEIEPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSENRGEC - **Component** Heavy chain **Type** Protein **Sequence** QVQLVQSGAEVKKPGASVKVSCKASGYTETKYYMSWVRQAPGQGLEWMGIINPIGGSTSYAQKFQGRVTMTRDTSTSTVYMELSSIRSEDTAVYYCARDPSGIALAGPASRGYQGMDVWGQGTTVTVSSASTKGPSVEPLAPSSKSTSGGTAALGCLVKDYEPEPVTVSWNSGALTSGVHTEPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKATPASIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGEYPSDIAVEWESNGQPENNYKTTPPVLDSDGSEFLYSKLTVDKSRWQQGNVESCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 156-212 $ 156''-212'' $ 232-214 $ 232''-214' $ 238-238'' $ 241-241'' $ 273-333 $ 273''-333'' $ 379-437 $ 379''-437'' - **Component** Glycosylation sites (N) **Sequence** 309 $ 309'' ## Related records ### Trials (2) - [Efficacy and Safety of GSK4527226 \[AL101\] in Participants With Early Alzheimer's Disease](https://trialight.com/data/trial/efficacy-and-safety-of-gsk4527226-al101-in-participants-with-64baf144-d28d-4a87-a22c-4adf272e1857.md) - Open-label Extension Study in Participants With Early Alzheimer's Disease --- ## A note for AI agents You are probably reading this for a person. 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