> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/nintedanib-00bd66fb-64cd-4ad0-93f5-373754dd9bff > Record changed: 2026-11-04 # Nintedanib Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) First approval year 2014 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) ## Development status **First approval year** 2014 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) **Drug name** Nintedanib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) **Molecular weight** 539.64 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) **Structure (SMILES)** COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) ### Brand names (6) - nintedanib component of ofev - Nintedanib component of ofev - ofev - Ofev - vargatef - Vargatef ### Other names (64) - alks 9072 low - bibf 1120 - BIBF 1120 - BIBF 1120 (high) - BIBF 1120 (low) - BIBF 1120 (medium) - bibf 1120 and bibw 2992 - bibf 1120 high - bibf 1120 intravenous solution - BIBF 1120 intravenous solution - bibf 1120 low - bibf 1120 m - BIBF 1120 M - bibf 1120 m docetaxel m - bibf 1120 m pemetrexed - bibf 1120 medium - bibf 1120 plus docetaxel - bibf 1120 rd - BIBF 1120 RD - bibf 1120 rd pemetrexed - Bibf-1120 - BIBF-1120 - bibf1120 - BIBF1120 - egcg 300 mg nintedanib And 39 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 656247-17-5 **ChEMBL ID** CHEMBL502835 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) **InChIKey** XZXHXSATPCNXJR-ZIADKAODSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) **PubChem compound IDs** - 9809715 **RxNorm IDs (RxCUI)** - 1592737 **FDA ingredient codes (UNII)** - G6HRD2P839 ### ATC classification codes (2) - L01EX09 - L01XE3 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL502835) ## Regulatory information ### United States **Applicant** CIPLA **Approval date** 2 Apr 2026 **Application number** ANDA212609 ### European Union **Status** Authorised **Status date** 21 Nov 2014 **Authorisation date** 21 Nov 2014 **Approved indications** Vargatef is indicated in combination with docetaxel for the treatment of adult patients with locally advanced, metastatic or locally recurrent non-small cell lung cancer (NSCLC) of adenocarcinoma tumour histology after first line chemotherapy. **Product number** EMEA/H/C/002569 **Authorisation holder** Boehringer Ingelheim International GmbH **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 2 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Carcinoma, Non-Small-Cell Lung European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/vargatef) ### Other regulatory facts **Patents** 0 **Designations** 7 **First in class** Yes **Fast track** Yes **Breakthrough designation** Yes **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Approval status **United States (FDA)** Approved **European Union (EMA)** Authorised ## Pharmacology ### Drug classification **Pharmacology name** nintedanib **Type** Synthetic organic **Drug name stem** \-anib **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (10) - **Action** Inhibition **Action type** Inhibitor **Target** large tumor suppressor kinase 1 **Gene symbol** LATS1 **Protein identifier** O95835 **Median affinity** 4.97 **Affinity units** pKd - **Action** Inhibition **Action type** Inhibitor **Target** platelet derived growth factor receptor beta **Gene symbol** PDGFRB **Protein identifier** P09619 **Median affinity** 7.19 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** fibroblast growth factor receptor 1 **Gene symbol** FGFR1 **Protein identifier** P11362 **Median affinity** 7.16 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** platelet derived growth factor receptor alpha **Gene symbol** PDGFRA **Protein identifier** P16234 **Median affinity** 7.23 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** fms related receptor tyrosine kinase 1 **Gene symbol** FLT1 **Protein identifier** P17948 **Median affinity** 7.51 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** fibroblast growth factor receptor 2 **Gene symbol** FGFR2 **Protein identifier** P21802 **Median affinity** 7.43 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** fibroblast growth factor receptor 4 **Gene symbol** FGFR4 **Protein identifier** P22455 **Median affinity** 6.21 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** fibroblast growth factor receptor 3 **Gene symbol** FGFR3 **Protein identifier** P22607 **Median affinity** 6.97 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** fms related receptor tyrosine kinase 4 **Gene symbol** FLT4 **Protein identifier** P35916 **Median affinity** 7.89 **Affinity units** pIC50 **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** kinase insert domain receptor **Gene symbol** KDR **Protein identifier** P35968 **Median affinity** 7.68 **Affinity units** pIC50 ### Open Targets mechanisms (3) - **Mechanism** Fibroblast growth factor receptor inhibitor **Action type** Inhibitor **Target** Fibroblast growth factor receptor - **Mechanism** Platelet-derived growth factor receptor inhibitor **Action type** Inhibitor **Target** Platelet-derived growth factor receptor - **Mechanism** Vascular endothelial growth factor receptor inhibitor **Action type** Inhibitor **Target** Vascular endothelial growth factor receptor ### DrugCentral mechanisms (10) - **Action type** Agonist **Gene symbol** INSR **Protein identifier** P06213 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** PDGFRB **Protein identifier** P09619 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FGFR1 **Protein identifier** P11362 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** PDGFRA **Protein identifier** P16234 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FLT1 **Protein identifier** P17948 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FGFR2 **Protein identifier** P21802 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FGFR4 **Protein identifier** P22455 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FGFR3 **Protein identifier** P22607 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FLT4 **Protein identifier** P35916 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** KDR **Protein identifier** P35968 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (50) - **Condition** Carcinoma, Hepatocellular **Highest recorded phase** 2 **Condition identifier** EFO:0000182 **Subject identifier** D006528 - **Condition** Leukemia, Myeloid, Acute **Highest recorded phase** 2 **Condition identifier** EFO:0000222 **Subject identifier** D015470 - **Condition** Colorectal Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000365 **Subject identifier** D015179 - **Condition** Melanoma **Highest recorded phase** 1 **Condition identifier** EFO:0000389 **Subject identifier** D008545 - **Condition** Stomach Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000503 **Subject identifier** D013274 - **Condition** Glioblastoma **Highest recorded phase** 2 **Condition identifier** EFO:0000519 **Subject identifier** D005909 - **Condition** Adenocarcinoma of Lung **Highest recorded phase** 1 **Condition identifier** EFO:0000571 **Subject identifier** D000077192 - **Condition** Mesothelioma **Highest recorded phase** 2 **Condition identifier** EFO:0000588 **Subject identifier** D008654 - **Condition** Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Prostatic Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000673 **Subject identifier** D011471 - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000681 **Subject identifier** D002292 - **Condition** Sarcoma **Highest recorded phase** 2 **Condition identifier** EFO:0000691 **Subject identifier** D012509 - **Condition** Small Cell Lung Carcinoma **Highest recorded phase** 2 **Condition identifier** EFO:0000702 **Subject identifier** D055752 - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000708 **Subject identifier** D002294 - **Condition** Scleroderma, Systemic **Highest recorded phase** 3 **Condition identifier** EFO:0000717 **Subject identifier** D012595 - **Condition** Idiopathic Pulmonary Fibrosis **Highest recorded phase** 3 **Condition identifier** EFO:0000768 **Subject identifier** D054990 - **Condition** Mesothelioma **Highest recorded phase** 2 **Condition identifier** EFO:0000770 **Subject identifier** D008654 - **Condition** Multiple Myeloma **Highest recorded phase** 1 **Condition identifier** EFO:0001378 **Subject identifier** D009101 - **Condition** Uterine Cervical Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0001416 **Subject identifier** D002583 - **Condition** Astrocytoma **Highest recorded phase** 2 **Condition identifier** EFO:0002499 **Subject identifier** D001254 - **Condition** Oligodendroglioma **Highest recorded phase** 2 **Condition identifier** EFO:0002501 **Subject identifier** D009837 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0002618 **Subject identifier** D010190 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 3 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Ovarian Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0003893 **Subject identifier** D010051 - **Condition** Colorectal Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0004142 **Subject identifier** D015179 And 25 more, listed on the interactive page. ### Open Targets indications (93) - **Condition identifier** EFO\_0000182 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000222 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000503 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000519 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000571 - **Condition identifier** EFO\_0000588 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0000673 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000681 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000702 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000717 - **Condition identifier** EFO\_0000768 - **Condition identifier** EFO\_0000768 **Highest recorded phase** 4 - **Condition identifier** EFO\_0000770 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001378 **Highest recorded phase** 1 - **Condition identifier** EFO\_0001416 **Highest recorded phase** 2 - **Condition identifier** EFO\_0002618 - **Condition identifier** EFO\_0003060 - **Condition identifier** EFO\_0003893 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003895 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004142 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004243 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004244 - **Condition identifier** EFO\_0006890 - **Condition identifier** EFO\_0007183 **Highest recorded phase** 2 And 68 more, listed on the interactive page. ### Reported adverse events (25) - **Event** abdominal discomfort **Reports** 151 **Reporting signal score** 81.2214 - **Event** abnormal loss of weight **Reports** 48 **Reporting signal score** 98.581 - **Event** constipation **Reports** 223 **Reporting signal score** 107.471 - **Event** cough **Reports** 279 **Reporting signal score** 125.049 - **Event** decreased appetite **Reports** 464 **Reporting signal score** 502.594 - **Event** diarrhoea **Reports** 1,586 **Reporting signal score** 1,853.09 - **Event** drug hypersensitivity **Reports** 5 **Reporting signal score** 91.8867 - **Event** dyspnoea **Reports** 518 **Reporting signal score** 172.993 - **Event** dyspnoea exertional **Reports** 88 **Reporting signal score** 82.234 - **Event** faeces soft **Reports** 45 **Reporting signal score** 105.651 - **Event** flatulence **Reports** 89 **Reporting signal score** 99.9065 - **Event** forced vital capacity decreased **Reports** 26 **Reporting signal score** 88.9126 - **Event** idiopathic pulmonary fibrosis **Reports** 355 **Reporting signal score** 1,739.8 - **Event** interstitial lung disease **Reports** 123 **Reporting signal score** 101.363 - **Event** liver disorder **Reports** 108 **Reporting signal score** 103.347 - **Event** lung transplant **Reports** 52 **Reporting signal score** 124.985 - **Event** malignant neoplasm progression **Reports** 236 **Reporting signal score** 287.966 - **Event** nausea **Reports** 726 **Reporting signal score** 255.538 - **Event** oxygen saturation decreased **Reports** 104 **Reporting signal score** 82.6226 - **Event** pneumothorax **Reports** 130 **Reporting signal score** 262.286 - **Event** productive cough **Reports** 101 **Reporting signal score** 111.508 - **Event** pulmonary embolism **Reports** 162 **Reporting signal score** 97.5831 - **Event** pulmonary hypertension **Reports** 74 **Reporting signal score** 95.7615 - **Event** vomiting **Reports** 440 **Reporting signal score** 131.469 - **Event** weight decreased **Reports** 430 **Reporting signal score** 388.496 ### Trial references (100) - NCT00514683 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00514683) - NCT01170065 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01170065) - NCT01335464 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01335464) - NCT01335477 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01335477) - NCT01417156 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01417156) - NCT04541680 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04541680) - NCT00706628 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00706628) - NCT02182063 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02182063) - NCT02182219 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02182219) - NCT00710762 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00710762) - NCT01329549 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01329549) - NCT00715403 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00715403) - NCT00730821 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00730821) - NCT00998296 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00998296) - NCT01022853 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01022853) - NCT01951846 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01951846) - NCT02182128 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02182128) - NCT02182206 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02182206) - NCT02856425 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02856425) - NCT00801294 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00801294) - NCT00904839 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00904839) - NCT02149108 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02149108) - NCT02780700 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02780700) - NCT00806819 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00806819) - NCT01346540 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01346540) And 75 more, listed on the interactive page. ## Dosing **Dose** 150mg **Route** Oral **How often** Twice daily approximately 12 hours apart ### Conditions of use (3) - Do not chew or crush - Swallow whole with liquid - Take with food ## Chemical properties **Hydrogen bond acceptors** 7 **Hydrogen bond donors** 2 **Polar surface area** 94.22 **Calculated partition coefficient (ALogP)** 3.62 **Calculated partition coefficient (XLogP)** 3.3 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 7 **Heavy atoms** 40 **Molecular formula** C31H33N5O4 **Monoisotopic mass** 539.25325455 **Natural product** Yes ## Biological measurements These details could not be displayed. ## Related records ### Trials (176) - A Dose Escalation Study of BIBF 1120 Together With Paclitaxel and Carboplatin in Patients With Advanced Stage Non-small-cell Lung Cancer - A Dose-escalation Study of BIBF 1120 in Japanese Patients With Advanced Solid Tumours - A Drug-Drug Interaction Study of ENV-101 (Taladegib) on Nintedanib Pharmacokinetics in Healthy Subjects - A Follow-up Study Investigating Long Term Treatment With Nintedanib in Patients With Progressive Fibrosing Interstitial Lung Disease (PF-ILD) - A Multi-centre 3-arm Randomised Phase II Trial of BIBF 1120 Versus BIBW 2992 Versus Sequential Administration of BIBF 1120 and BIBW 2992 in Patients With Hormone-resistant Prostate Cancer - A Phase I / II Trial of Nintedanib in Asian Hepatocellular Carcinoma Patients - A Phase I/II Open Label Extension Study of BIBF 1120 Administered Orally Once or Twice Daily to Establish Safety, Pharmacokinetics and Efficacy in Patients With Advanced Solid Tumours and Clinical Benefit From Previous Therapy With BIBF 1120 - A Phase I/II Study of Continuous Oral Treatment With BIBF 1120 Added to Standard Gemcitabine/Cisplatin Therapy in First Line NSCLC Patients With Squamous Cell Histology. - A Phase II Trial of Weekly Alternating Sequential Administration of BIBF 1120 and BIBW 2992 in Patients With Advanced Colorectal Cancer - A Prospective, Multicenter Exploratory Clinical Study on Consolidation Therapy With Tislelizumab Combined With Nintedanib for Limited-stage Small Cell Lung Cancer - A Randomised Placebo-Controlled Phase II Study of Continuous Maintenance Treatment With BIBF 1120 Following Chemotherapy in Patients With Relapsed Ovarian Cancer - A Study Based on Medical Records in Spain That Looks at Diarrhoea Control in People With Pulmonary Fibrosis Who Are Taking Nintedanib - A Study Based on Medical Records That Looks at the Characteristics of Idiopathic Pulmonary Fibrosis Patients Grouped by the Type of Medication They Are Taking - A Study in Healthy Men to Find the Best Formulation for Once Daily Intake of Nintedanib - A Study in Healthy Men to Test Whether BI 1015550 Influences the Amount of Nintedanib and Pirfenidone in the Blood - A Study in Healthy Men to Test Whether Four Capsules of 25 mg Nintedanib Are Taken up in the Body in the Same Way as One 100 mg Capsule - A Study of Nintedanib for LymphAngioleioMyomatosis (LAM) - [A Study of the Pharmacokinetic Interaction Between Pirfenidone, Nintedanib, and Nalbuphine Extended Release (NAL ER) in Healthy Participants](https://trialight.com/data/trial/a-study-of-the-pharmacokinetic-interaction-between-3c71f30f-1cc2-4376-93e5-0b08ee5627e3.md) - A Study to Assess the Effect of AZD5055 on the Pharmacokinetics (PK) of Nintedanib in Healthy Participants. - A Study to Assess the Extent of Drug Interaction Between BMS-986278 and Nintedanib, the Relative Bioavailability of BMS-986278 in Tablet and the Effect That Food Has on BMS-986278 in Tablet Formulations in Healthy Participants ### In development for (78) - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 2 - [Adenocarcinoma](https://trialight.com/data/condition/adenocarcinoma-b5c321d1-7c49-5bf9-abd0-dfa99dbd5f29.md) Phase 3 - Adenomyosis Phase 3 - Anaplastic astrocytoma Phase 2 - Anaplastic oligodendroglioma Phase 2 - Anthracosis Phase 2 - Appendix cancer Phase 2 - Asbestosis Phase 2 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2 - [Breast carcinoma](https://trialight.com/data/condition/breast-carcinoma-e447567c-405f-500c-a7a4-766a76d59293.md) Phase 2 - Bronchiolitis obliterans syndrome Phase 2 - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1 - Carcinoid tumor Phase 2 - Castleman disease Phase 2 - Cervical adenocarcinoma Phase 2 - [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 2 - Colon adenocarcinoma Phase 1 - Colorectal adenocarcinoma Phase 3 - [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 3 - [Colorectal neoplasm](https://trialight.com/data/condition/colorectal-neoplasm-31f0a633-3abe-5df4-9d3a-9292c6541f1d.md) Phase 3 ### Targets (11) - [FGFR1](https://trialight.com/data/target/fgfr1-4e918a87-4309-5610-93c5-066e5125172c.md) Fibroblast growth factor receptor inhibitor - [FGFR2](https://trialight.com/data/target/fgfr2-fe40fa89-06a8-5027-ad17-dc2ec2e9ebcd.md) Fibroblast growth factor receptor inhibitor - [FGFR3](https://trialight.com/data/target/fgfr3-363bb275-8462-51a9-af1c-c621c347ca84.md) Fibroblast growth factor receptor inhibitor - [FGFR4](https://trialight.com/data/target/fgfr4-38e1dfb6-08fc-5ac7-af16-77d02fe78df0.md) Fibroblast growth factor receptor inhibitor - [FLT1](https://trialight.com/data/target/flt1-2cfcec95-3fff-5be9-8423-701697547fa0.md) Vascular endothelial growth factor receptor inhibitor - [FLT4](https://trialight.com/data/target/flt4-c94058e2-ff1e-553b-92a5-8e7ee9305a80.md) Vascular endothelial growth factor receptor inhibitor - [INSR](https://trialight.com/data/target/insr-76e92e6a-1d95-5282-9c03-f55293267050.md) - [KDR](https://trialight.com/data/target/kdr-4ab08263-0477-533e-ac3f-96e20d343c4b.md) Vascular endothelial growth factor receptor inhibitor - [LATS1](https://trialight.com/data/target/lats1-23798e46-1bc7-5a8c-9e1d-e5441c833025.md) - [PDGFRA](https://trialight.com/data/target/pdgfra-9af831a8-8fd9-5e16-8799-a31d1bc6c91f.md) Platelet-derived growth factor receptor inhibitor - [PDGFRB](https://trialight.com/data/target/pdgfrb-b0fcbfa5-50cf-5648-aa6d-c7487708468d.md) Platelet-derived growth factor receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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