> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/nezutatug-7e36e8b4-5091-4870-bbbe-74a343c19d0d > Record changed: 2026-10-13 # Nezutatug Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315023) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315023) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315023) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315023) **Drug name** Nezutatug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315023) ### Other names (13) - Gamma1 heavy chain humanized (1-450) \[VH (Homo sapiens IGHV4-31\*01 (89.9%) -(IGHD) -IGHJ4\*01 (92.9%), CDR-IMGT \[9.7.13\] (26-34.52-58.97-109)) (1-120) -Homo sapiens IGHG1\*01 (100%), G1m17,1 CH1 K120, D12, L14 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)\], (223-214')-disulfide with kappa light chain humanized (1'-214') \[V-KAPPA (Homo sapiens IGKV1-12\*01 (85.3%)-IGKJ2\*01 (100%), CDR-IMGT \[6.3.9\] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')\]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1,glycoform alfa - gamma1 heavy chain humanized 1 450 vh homo sapiens ighv4 31 01 89 9 ighd ighj4 01 92 9 cdr imgt 9 7 13 26 34 52 58 97 109 1 120 homo sapiens ighg1 01 100 g1m17 1 ch1 k120 d12 l14 ch1 k120 217 121 218 hinge 1 15 219 233 ch2 234 343 ch3 d12 359 l14 361 344 448 chs 449 450 121 450 223 214 disulfide with kappa light chain humanized 1 214 v kappa homo sapiens igkv1 12 01 85 3 igkj2 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 229 229 232 232 bisdisulfide produced in chinese hamster ovary cho cells derived from the cell line cho k1 glycoform alfa - hmbd 001 - Hmbd-001 - HMBD-001 - immunoglobulin g1 anti human epidermal growth factor receptor her3 human mus musculus monoclonal hmbd 001 γ1 chain disulfide with human mus musculus monoclonal hmbd 001 κ chain dimer - Immunoglobulin G1, anti-(human epidermal growth factor receptor HER3) (human-Mus musculus monoclonal HMBD-001 γ1-chain), disulfide with human-Mus musculus monoclonal HMBD-001 κ-chain, dimer - nezutatug - Nezutatug - Nezutatug (Immunoglobulin G1-kappa, anti-\[Homo sapiens ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3)\], humanized monoclonal antibody) - nezutatug \[INN\] - nezutatug immunoglobulin g1 kappa anti homo sapiens erbb3 receptor tyrosine protein kinase erbb 3 her3 humanized monoclonal antibody - nezutatug inn ## Identifiers **CAS registry numbers** - 2673271-78-6 **ChEMBL ID** CHEMBL5315023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315023) **FDA ingredient codes (UNII)** - HZZ2SGC2TW ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (2) - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 1 **Condition identifier** EFO:0003060 **Subject identifier** D002289 ### Open Targets indications (5) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005096 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008315 **Highest recorded phase** 1 ### Trial references - NCT05910827 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05910827) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** QVQLQESGPGLVKPSQTLSLTCTVSGYSITSGYSWHWIRQHPGKGLEWIGSIRYSGGTDYNPSLKSLVTISADTSKNQFSLKLSSVTAADTAVYYCARMTTAPWYPFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSVSASVGDRVTITCKASQIVGSNVAWYQQKPGKAPEPLIYSASYLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSSHPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 300 $ 300'' - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 147-203 $ 147''-203'' $ 223-214' $ 223''-214''' $ 229-229'' $ 232-232'' $ 264-324 $ 264''-324'' $ 370-428 $ 370''-428'' ## Related records ### Trials (3) - A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours - [A Phase Ib/II Study of an Anti-HER3 Antibody, HMBD-001, With Cetuximab +/- Docetaxel in Advanced Squamous Cell Cancers](https://trialight.com/data/trial/a-phase-ib-ii-study-of-an-anti-her3-antibody-hmbd-001-with-026a36f4-4a47-44e5-942f-01f081708ee9.md) - Study of an Anti-HER3 Antibody, HMBD-001, With or Without Chemotherapy in Patients With Solid Tumors Harboring an NRG1 Fusion or HER3 Mutation ### In development for (2) - Neoplasm Phase 2 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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