> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/nerandomilast-64fce164-408a-4136-b057-e9aaa9df5d35 > Record changed: 2026-10-13 # Nerandomilast Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314532) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314532) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314532) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314532) **Drug name** Nerandomilast Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314532) **Molecular weight** 448.98 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314532) **Structure (SMILES)** These details could not be displayed. ### Other names (16) - bi 1015550 - BI 1015550 - BI 1015550 (C-14) - BI 1015550 (Nerandomilast) - BI 1015550 6 mg - BI-1015550 - jascayd - JASCAYD - nerandomilast - Nerandomilast - nerandomilast \[INN\] - NERANDOMILAST \[USAN\] - Nerandomilast \[WHO-DD\] - nerandomilast inn - nerandomilast usan - nerandomilast who dd ## Identifiers **ATC classification codes** - L04AA61 **CAS registry numbers** - 1423719-30-5 **ChEMBL ID** CHEMBL5314532 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314532) **InChIKey** UHYCLWAANUGUMN-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314532) **RxNorm IDs (RxCUI)** - 2725523 **FDA ingredient codes (UNII)** - I5DGT51IB8 ### PubChem compound IDs (2) - 71278111 - 166177189 ## Regulatory information ### European Union **Status** Authorised **Status date** 15 Jul 2026 **Authorisation date** 15 Jul 2026 **Approved indications** Jascayd is indicated for the treatment of adult patients with Idiopathic Pulmonary Fibrosis (IPF). Jascayd is indicated for the treatment of adult patients with Progressive Pulmonary Fibrosis (PPF). **Product number** EMEA/H/C/006405 **Authorisation holder** Boehringer Ingelheim International GmbH **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** Yes **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Idiopathic Pulmonary Fibrosis European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/jascayd) ### Other regulatory facts **Patents** 5 **Designations** 5 **Earliest recorded loss of exclusivity** 22 Oct 2038 **First in class** No **Fast track** No **Breakthrough designation** Yes **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Pharmacology name** example 2 \[WO2013026797A1\] **Type** Synthetic organic **Drug name stem** \-ast ### Mechanisms of action - **Action** Inhibition **Action type** Inhibitor **Target** phosphodiesterase 4B **Gene symbol** PDE4B **Protein identifier** Q07343 **Median affinity** 8.14 **Affinity units** pIC50 ### Investigated indications - **Condition** Fibrosis **Highest recorded phase** 2 **Condition identifier** EFO:0006890 **Subject identifier** D005355 ### Open Targets indications (8) - **Condition identifier** EFO\_0000768 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004244 **Highest recorded phase** 3 - **Condition identifier** EFO\_0006890 - **Condition identifier** HP\_0000083 **Highest recorded phase** 1 - **Condition identifier** HP\_0001399 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004976 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005100 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0015925 **Highest recorded phase** 3 ## Chemical properties **Hydrogen bond acceptors** 8 **Hydrogen bond donors** 2 **Polar surface area** 110.12 **Calculated partition coefficient (ALogP)** 2.29 **Calculated partition coefficient (XLogP)** 1.3 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 5 **Heavy atoms** 30 **Molecular formula** C20H25ClN6O2S **Monoisotopic mass** 448.1448229 **Natural product** No ## National Drug Codes - 0597-2465 - 0597-7313 ## Related records ### Trials (36) - [A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast](https://trialight.com/data/trial/a-follow-up-study-to-test-long-term-treatment-with-790ffd1c-da14-49d0-9480-2f1f7671103e.md) - A Study in Healthy Chinese People to Test How Different Doses of BI 1015550 Are Taken up in the Body - A Study in Healthy Men to Find Out How BI 1015550 is Taken up and Handled by the Body - A Study in Healthy Men to Test How BI 1015550 is Taken up and Handled by the Body - A Study in Healthy Men to Test How Bosentan Influences the Amount of Nerandomilast in the Blood - A Study in Healthy Men to Test Whether BI 1015550 Influences the Amount of Midazolam in the Blood - A Study in Healthy Men to Test Whether BI 1015550 Influences the Amount of Nintedanib and Pirfenidone in the Blood - A Study in Healthy Men to Test Whether Carbamazepine Influences the Amount of Nerandomilast in the Blood - A Study in Healthy People to Compare 2 Different Formulations of Nerandomilast Tablets When Taken With or Without Food - A Study in Healthy People to Compare How 2 Different High Dose Formulations of BI 1015550 Are Taken up in the Body - A Study in Healthy People to Compare How 2 Different Low Dose Formulations of BI 1015550 Are Taken up in the Body - A Study in Healthy People to Test How BI 1015550 is Taken up in the Body When Given With or Without Food - A Study in Healthy People to Test Whether Different Doses of BI 1015550 Have Potential to Induce Heart Rhythm Abnormalities - A Study in People With Idiopathic Pulmonary Fibrosis to Test Whether Pirfenidone Influences the Amount of BI 1015550 in the Blood - A Study to Find Out How Nerandomilast is Tolerated, Handled by the Body, and if it Helps Children and Adolescents With Interstitial Lung Disease (FIBRONEER-chILD) - [A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)](https://trialight.com/data/trial/a-study-to-find-out-whether-bi-1015550-improves-lung-b5be8e44-6c74-4fcb-9d38-b2d60976560e.md) - [A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)](https://trialight.com/data/trial/a-study-to-find-out-whether-bi-1015550-improves-lung-1045d0bd-5e73-47e5-b5af-a646946c705a.md) - A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Kidney Problems - A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Liver Problems - A Study to Test How Different Doses of Nerandomilast (BI 1015550) Are Taken up in the Body of Healthy Japanese Men ### In development for (1) - [Interstitial lung disease](https://trialight.com/data/condition/interstitial-lung-disease-745f5770-ba0b-517d-b691-5b9731a03266.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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