> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/nelistotug-4fa295f8-c7a6-45c9-bd45-9f23118cd297 > Record changed: 2026-10-13 # Nelistotug Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315022) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315022) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315022) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315022) **Drug name** Nelistotug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315022) ### Other names (20) - Gamma1 heavy chain Homo sapiens (1-452) \[VH(Homo sapiens IGHV1-69\*01 (95.9%) -(IGHD)-IGHJ1\*01 (90.9%) L123>T (117), CDR-IMGT \[8.8.15\](26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1\*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 D12 (361), L14 (363) (346-450), CHS (451-452)) (123-452)\], (225-213')-disulfide with kappa light chain Homo sapiens (1'-213') \[V-KAPPA (Homo sapiens IGKV1-39\*01 (95.7%) -IGKJ4\*01 (91.7%), CDR-IMGT \[6.3.8\] (27-32.50-52.89-96)) (1'-106') -Homo sapiens IGKC\*01 (100%), Km3, A45.1 (152), V101 (190) (107'-213')\]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO) Cell line, glycoform alfa - gamma1 heavy chain homo sapiens 1 452 vh homo sapiens ighv1 69 01 95 9 ighd ighj1 01 90 9 l123 t 117 cdr imgt 8 8 15 26 33 51 58 97 111 1 122 homo sapiens ighg1 01 100 g1m17 1 ch1 k120 ch3 d12 l14 ch1 k120 219 123 220 hinge 1 15 221 235 ch2 236 345 ch3 d12 361 l14 363 346 450 chs 451 452 123 452 225 213 disulfide with kappa light chain homo sapiens 1 213 v kappa homo sapiens igkv1 39 01 95 7 igkj4 01 91 7 cdr imgt 6 3 8 27 32 50 52 89 96 1 106 homo sapiens igkc 01 100 km3 a45 1 152 v101 190 107 213 dimer 231 231 234 234 bisdisulfide produced in chinese hamster ovary cho cell line glycoform alfa - gsk 6097608 - Gsk 6097608 - GSK-6097608 - gsk6097608 - Gsk6097608 - GSK6097608 - immunoglobulin g1 anti human cd96 antigen human monoclonal gsk6097608 γ1 chain disulfide with human monoclonal gsk6097608 κ chain dimer - Immunoglobulin G1, anti-(human CD96 antigen) (human monoclonal GSK6097608 γ1-chain), disulfide with human monoclonal GSK6097608 κ-chain, dimer - nelistotug - Nelistotug - Nelistotug (immunoglobulin G1-kappa, anti-\[Homo sapiens CD96 (T cell activation increased late expression, TACTILE, T-cell surface protein tactile)\], Homo sapiens monoclonal antibody) - nelistotug \[INN\] - NELISTOTUG \[USAN\] - Nelistotug \[WHO-DD\] - nelistotug immunoglobulin g1 kappa anti homo sapiens cd96 t cell activation increased late expression tactile t cell surface protein tactile homo sapiens monoclonal antibody - nelistotug inn - nelistotug usan - nelistotug who dd ## Identifiers **CAS registry numbers** - 2645437-82-5 **ChEMBL ID** CHEMBL5315022 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315022) **FDA ingredient codes (UNII)** - 7MCC43O1YB ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (3) - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 2 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Head and Neck Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0005950 **Subject identifier** D006258 ### Open Targets indications (4) - **Condition identifier** EFO\_0000616 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0010150 **Highest recorded phase** 2 ### Trial references (4) - NCT03739710 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03739710) - NCT04446351 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04446351) - NCT05565378 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05565378) - NCT06062420 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06062420) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** QVQLVQSGAEVKKPGSSVKVSCKASGGTEVEYAISWVRQAPGQGLEWMGGITPAFGTAQYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGAGYYGDKDPMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 133'-193' $ 133'''-193''' $ 149-205 $ 149''-205'' $ 225-213'' $ 22''-213'''' $ 231-231'' $ 234-234'' $ 266-326 $ 266''-326'' $ 372-430 $ 372''-430'' - **Component** Light chain **Type** Protein **Sequence** DIQLTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQVLHTITEGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 302 $ 302'' ## Related records ### Trials (6) - [A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202](https://trialight.com/data/trial/a-platform-study-of-novel-immunotherapy-combinations-as-f887453f-7656-4251-ba87-8be3fcd752b0.md) - [A Platform Study of Novel Immunotherapy Combinations in Participants With Previously Untreated, Advanced/Metastatic Non-Small-Cell Lung Cancer](https://trialight.com/data/trial/a-platform-study-of-novel-immunotherapy-combinations-in-29430999-4540-4481-8d22-236d21ffd249.md) - [First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/first-time-in-human-study-of-gsk4381562-in-participants-with-2b234294-67e5-437c-b4a4-a51fc28f3e3b.md) - Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Participants With Non-small Cell Lung Cancer (NSCLC) - Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Participants With Non-small Cell Lung Cancer (NSCLC) - Sub-study 3 - Study of the Safety and Effectiveness of GSK6097608 in Participants With Advanced Solid Tumors ### In development for (3) - [Head and neck neoplasm](https://trialight.com/data/condition/head-and-neck-neoplasm-6436d68c-825f-5a7a-bb29-99e9ae9e009a.md) Phase 2 - Neoplasm Phase 2 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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