> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/neladalkib-f4ff314e-7741-4472-b286-490cf715d668
> Record changed: 2026-10-13

# Neladalkib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068023)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068023)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068023)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068023)

**Drug name**

Neladalkib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068023)

**Molecular weight**

452.92

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068023)

**Structure (SMILES)**

CCn1nc(Cl)c2c1-c1cnc(N)c(c1)O\[C@H\](C)c1cc(F)ccc1-c1nn(C)cc1C2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068023)

### Other names (16)

- 4 8 metheno 8h dipyrazolo 3 4 h 4 3 k 2 5 benzoxaazacyclotetradecin 7 amine 1 chloro 3 ethyl 12 fluoro 3 10 16 18 tetrahydro 10 16 dimethyl 10r
- 4,8-Metheno-8H-dipyrazolo\[3,4-h:4′,3′-k\]\[2,5\]benzoxaazacyclotetradecin-7-amine, 1-chloro-3-ethyl-12-fluoro-3,10,16,18-tetrahydro-10,16-dimethyl-, (10R)-
- neladalkib
- Neladalkib
- Neladalkib (NVL-655)
- Neladalkib \[INN\]
- Neladalkib \[USAN\]
- Neladalkib \[WHO-DD\]
- neladalkib inn
- neladalkib nvl 655
- neladalkib usan
- neladalkib who dd
- nuv 655
- NUV-655
- nvl 655
- NVL-655

## Identifiers

**CAS registry numbers**

- 2739866-40-9

**ChEMBL ID**

CHEMBL6068023

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068023)

**InChIKey**

FWZSCAQEBTVTOM-GFCCVEGCSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068023)

**PubChem compound IDs**

- 164718816

**FDA ingredient codes (UNII)**

- J32P26A6BC

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

neladalkib

**Type**

Synthetic organic

**Drug name stem**

\-alkib

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
ALK receptor tyrosine kinase

**Gene symbol**  
ALK

**Protein identifier**  
Q9UM73

**Median affinity**  
9

**Affinity units**  
pIC50

### Investigated indications

- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369

### Open Targets indications (3)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
3

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

1

**Polar surface area**

83.78

**Calculated partition coefficient (ALogP)**

4.78

**Calculated partition coefficient (XLogP)**

3.7

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

1

**Heavy atoms**

32

**Molecular formula**

C23H22ClFN6O

**Monoisotopic mass**

452.1527652

**Natural product**

No

## Related records

### Trials (3)

- [A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)](https://trialight.com/data/trial/a-study-of-neladalkib-nvl-655-in-patients-with-advanced-56190eab-981f-4038-b03b-4ccae9704b2a.md)
- Expanded Access Program of Neladalkib (NVL-655) for Patients With Advanced ALK+ NSCLC or Other ALK+ Solid Tumors
- Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

### In development for (1)

- Neoplasm Phase 2

---

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