> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/neisseria-meningitidis-polysaccharide-conjugated-to-tetanus-302abcc3-57a8-4a46-915e-9bd6f28a7ec6 > Record changed: 2026-10-13 # Neisseria meningitidis polysaccharide conjugated to tetanus toxoid Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068498) Drug type Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068498) First approval year 2012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068498) ## Development status **First approval year** 2012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068498) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068498) ## Names and chemistry **Drug type** Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068498) **Drug name** Neisseria meningitidis polysaccharide conjugated to tetanus toxoid Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068498) ### Brand names (12) - menquadfi - Menquadfi - neisseria meningitidis group a capsular polysaccharide tetanus toxoid conjugate antigen component of penbraya - Neisseria meningitidis group a capsular polysaccharide tetanus toxoid conjugate antigen component of penbraya - neisseria meningitidis group c capsular polysaccharide tetanus toxoid conjugate antigen component of penbraya - Neisseria meningitidis group c capsular polysaccharide tetanus toxoid conjugate antigen component of penbraya - neisseria meningitidis group w 135 capsular polysaccharide tetanus toxoid conjugate antigen component of penbraya - Neisseria meningitidis group w-135 capsular polysaccharide tetanus toxoid conjugate antigen component of penbraya - neisseria meningitidis group y capsular polysaccharide tetanus toxoid conjugate antigen component of penbraya - Neisseria meningitidis group y capsular polysaccharide tetanus toxoid conjugate antigen component of penbraya - nimenrix - Nimenrix ### Other names (18) - gsk biolgicals meningococcal vaccine 134612 nimenrix - GSK Biolgicals' meningococcal vaccine 134612 (Nimenrix) - GSK Biologicals' Meningococcal vaccine GSK134612 (Nimenrix) - Meningococcal vaccine GSK134612 (Nimenrix) - neisseria meningitidis group a capsular polysaccharide tetanus toxoid conjugate antigen - Neisseria meningitidis group a capsular polysaccharide tetanus toxoid conjugate antigen - neisseria meningitidis group c capsular polysaccharide tetanus toxoid conjugate antigen - Neisseria meningitidis group c capsular polysaccharide tetanus toxoid conjugate antigen - neisseria meningitidis group w 135 capsular polysaccharide tetanus toxoid conjugate antigen - Neisseria meningitidis group w-135 capsular polysaccharide tetanus toxoid conjugate antigen - neisseria meningitidis group y capsular polysaccharide tetanus toxoid conjugate antigen - Neisseria meningitidis group y capsular polysaccharide tetanus toxoid conjugate antigen - neisseria meningitidis polysaccharide conjugated to tetanus toxoid - Neisseria meningitidis polysaccharide conjugated to tetanus toxoid - Nimenrix - Nimenrix (GSK134612 vaccine) - Nimenrix (Meningococcal vaccine 134612) - Nimenrix™ ## Identifiers **ChEMBL ID** CHEMBL6068498 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068498) ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Mechanisms of action - **Mechanism** Polysaccharide conjugated to Tetanus toxoid vaccine antigen **Action type** VACCINE\_ANTIGEN **Target** Polysaccharide conjugated to Tetanus toxoid ### Investigated indications (2) - **Condition** Vaccination **Highest recorded phase** 4 **Condition identifier** EFO:0004292 **Subject identifier** D014611 - **Condition** Meningitis, Meningococcal **Highest recorded phase** 4 **Condition identifier** EFO:1001040 **Subject identifier** D008585 ### Open Targets indications (5) - **Condition identifier** EFO\_0000584 - **Condition identifier** EFO\_0004249 - **Condition identifier** MONDO\_0004796 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005373 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0018059 **Highest recorded phase** 4 ### Reported adverse events (5) - **Event** asthenia **Reports** 7 **Reporting signal score** 17.4282 - **Event** eosinophilia **Reports** 5 **Reporting signal score** 22.7049 - **Event** generalised oedema **Reports** 5 **Reporting signal score** 26.037 - **Event** hyperpyrexia **Reports** 7 **Reporting signal score** 45.9842 - **Event** rash erythematous **Reports** 5 **Reporting signal score** 20.6845 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (34) - A Clinical Trial to Assess the Safety, Tolerability and Immunogenicity of MenABCWY in Healthy Infants - [A Safety, Tolerability, and Immunogenicity Study of mRNA-1345 and mRNA-1365 in Participants Aged 5 Months to <24 Months](https://trialight.com/data/trial/a-safety-tolerability-and-immunogenicity-study-of-mrna-1345-052dcf45-abe4-428a-9ed4-3afd71c12084.md) - [A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella Disease and Typhoid Fever in Infants](https://trialight.com/data/trial/a-study-to-evaluate-safety-reactogenicity-and-immune-e71b2924-2aba-4229-b641-f00520504789.md) - A Study to Evaluate the Safety and Immunogenicity of a Candidate Ebola Vaccine in Children - A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of Adenovirus Serotype 26 Based Respiratory Syncytial Virus Pre-fusion (Ad26.RSV.Pre-F) Vaccine in RSV-Seronegative Toddlers 12 to 24 Months of Age - Co-administration of Meningococcal Vaccine GSK134612 and Pneumococcal Vaccine GSK1024850A vs Individual Administration - Co-Administration of Meningococcal Vaccine GSK134612 With Infanrix Hexa™ Versus Individual Administration of Each Vaccine - Comparison of GlaxoSmithKline (GSK)134612 in Subjects With Increased Risk for Meningococcal Disease Versus Healthy Subjects - Comparison of GSK Biologicals' Meningococcal Vaccine (GSK134612) and Licensed MenC-CRM197 Vaccine in Healthy Children - Comparison of GSK134612 in Subjects Previously Vaccinated Against Meningococcal Disease Versus Non-vaccinated Subjects - Concomitant Administration of a New Hexavalent Vaccine With a Meningococcal Serogroup C Conjugate Vaccine in Healthy Infants During Primary Series Immunisation Followed by Booster Vaccination - Immuno,Safety of GSK Vaccine 134612 Given at Age of 12-15 Months 15-18 Months Post-priming With GSK Vaccine 792014 - Immunogenicity and Safety of Meningococcal Vaccine GSK 134612 Co-administered With Pneumococcal and DTPa-HBV-IPV/Hib Vaccines - Immunogenicity and Safety of Meningococcal Vaccine GSK134612 Given as 1 or 2 Doses to Healthy 9-12 Months Old Toddlers. - Immunogenicity and Safety of Meningococcal Vaccine GSK134612 vs. Menactra® in Healthy Adolescent/Adults Aged 10-25 Years. - Immunogenicity and Safety Study of 1 and 2 Doses of GlaxoSmithKline (GSK) Biologicals' Meningococcal Vaccine MenACWY-TT (GSK134612) in Toddlers, Persistence up to 5 Years After Vaccination and Co-administration With Pfizer's Prevenar 13™Vaccine - [Immunogenicity and Safety Study of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Administered in Healthy Infants and Toddlers in China](https://trialight.com/data/trial/immunogenicity-and-safety-study-of-an-investigational-bf14b024-4295-414d-bbd2-67883072c0d8.md) - Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Meningococcal Conjugate Vaccine (GSK134612) When Co-administered With Boostrix® in Subjects Between 11 and 25 Years of Age - Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Meningococcal Vaccine With or Without Co-administration of Cervarix and Boostrix in Female Adolescents and Young Adults - Lot Consistency, Immuno, Safety of Meningococcal Vaccine GSK134612 Given With Fluarix™ to 18-55 Year-Old Adults ### Approved for (1) - [Meningococcal meningitis](https://trialight.com/data/condition/meningococcal-meningitis-986c81ca-25d6-5c71-bad2-6d638b296341.md) ### Other linked conditions (2) - Infectious meningitis - [Meningococcal infection](https://trialight.com/data/condition/meningococcal-infection-127e031a-0256-5064-a935-b84efd154e0d.md) --- ## A note for AI agents You are probably reading this for a person. 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