> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/nbl-015-7ff2da7c-4c64-436c-b336-652563a6e9bd
> Record changed: 2026-10-13

# NBL-015

Highest phase reached

Phase 1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314994)

Drug type

Protein

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/7EM2VXC85Q)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314994)

## Names and chemistry

**Drug type**

Protein

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/7EM2VXC85Q)

**Drug name**

NBL-015

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314994)

### Other names (7)

- Fully human monoclonal IgG1 antibody against the type 2 isoform of human Claudin 18 protein (Claudin 18.2).
- fully human monoclonal igg1 antibody against the type 2 isoform of human claudin 18 protein claudin 18 2
- nbl 015
- nbl 015 anti claudin18 2 mab
- Nbl-015
- NBL-015
- Nbl-015 (anti-claudin18.2 mab)

## Identifiers

**ChEMBL ID**

CHEMBL5314994

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314994)

**FDA ingredient codes (UNII)**

- 7EM2VXC85Q

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Investigated indications

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369

### Open Targets indications

- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
1

### Trial references

- NCT05153096  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05153096)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

## Related records

### Trials (3)

- Clinical Study of CLDN18.2-targeting CAR T Cells in Advanced Solid Tumors With Positive CLDN18.2 Expression
- [Evaluation of the Safety and Efficacy of NBL-015 in Patients With Advanced Solid Tumors](https://trialight.com/data/trial/evaluation-of-the-safety-and-efficacy-of-nbl-015-in-patients-7d422aa4-d869-436a-afbe-d3dd14c05b69.md)
- Mesothelin and Claudin 18.2 Dual-Target CAR-T Therapy in Advanced Pancreatic Cancer

### In development for (1)

- Neoplasm Phase 1

---

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