> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/navacaprant-78d4464a-3bbf-45a0-8ac7-c39a5b1af807
> Record changed: 2026-10-13

# Navacaprant

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4592045)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4592045)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4592045)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4592045)

**Drug name**

Navacaprant

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4592045)

**Molecular weight**

453.56

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4592045)

**Structure (SMILES)**

CCc1cc(F)c2nc(N3CCC(NC4CCOCC4)CC3)c(-c3nc(C)no3)c(C)c2c1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4592045)

### Other names (24)

- btrx 140
- btrx 335140
- BTRX-140
- Btrx-335140
- BTRX-335140
- btrx335140
- BTRX335140
- cym 53093
- CYM-53093
- cym53093
- CYM53093
- navacaprant
- Navacaprant
- navacaprant \[INN\]
- NAVACAPRANT \[USAN\]
- navacaprant inn
- navacaprant usan
- nmra 140
- nmra 335140
- NMRA-140
- Nmra-335140
- NMRA-335140
- nmra335140
- NMRA335140

## Identifiers

**CAS registry numbers**

- 2244614-14-8

**ChEMBL ID**

CHEMBL4592045

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4592045)

**InChIKey**

CQOJHAJWCDJEAT-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4592045)

**PubChem compound IDs**

- 137434175

**FDA ingredient codes (UNII)**

- XK5ILZ28KI

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

navacaprant

**Type**

Synthetic organic

**Drug name stem**

\-caprant

### Mechanisms of action (4)

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
μ receptor

**Gene symbol**  
OPRM1

**Protein identifier**  
P35372

**Median affinity**

6.96

**Affinity units**  
pIC50
- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
δ receptor

**Gene symbol**  
OPRD1

**Protein identifier**  
P41143

**Median affinity**

5.19

**Affinity units**  
pIC50
- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
κ receptor

**Gene symbol**  
OPRK1

**Protein identifier**  
P41145

**Median affinity**

9.1

**Affinity units**  
pIC50

**Primary target**  
Yes
- **Mechanism**  
Kappa opioid receptor antagonist

**Action type**  
Antagonist

**Target**  
Kappa-type opioid receptor

**Protein identifier**  
P41145

### Open Targets mechanisms

- **Mechanism**  
Kappa opioid receptor antagonist

**Action type**  
Antagonist

**Target**  
Kappa-type opioid receptor

### Investigated indications (2)

- **Condition**  
Depressive Disorder, Major

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0002009

**Subject identifier**  
D003865
- **Condition**  
Depression

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0002050

**Subject identifier**  
D003863

### Open Targets indications (3)

- **Condition identifier**  
EFO\_0007634

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002009

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0002050

### Trial references (4)

- NCT04221230  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04221230)
- NCT06029439  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06029439)
- NCT06058013  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06058013)
- NCT06058039  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06058039)

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

1

**Polar surface area**

76.31

**Calculated partition coefficient (ALogP)**

4.34

**Calculated partition coefficient (XLogP)**

4.7

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

5

**Heavy atoms**

33

**Molecular formula**

C25H32FN5O2

**Monoisotopic mass**

453.25400344

**Natural product**

No

## Evidence counts

**Recorded assays**

36

**Active assays**

10

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (6)

- Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs Placebo
- Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder
- Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder
- [Study to Assess the Safety and Effectiveness of NMRA-335140-501](https://trialight.com/data/trial/study-to-assess-the-safety-and-effectiveness-of-nmra-335140-88df68f6-d817-490c-a172-15d860ebbbd0.md)
- Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder
- To Evaluate the Effects of NMRA-335140 on Symptoms of Major Depression in Participants With Bipolar II Disorder.

### In development for (2)

- [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) Phase 1
- [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md) Phase 3

### Targets (1)

- [OPRK1](https://trialight.com/data/target/oprk1-7b0a0fa0-a4b4-537b-bd00-d871256424e5.md) Kappa opioid receptor antagonist

---

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