> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/nadroparin-calcium-e2fda760-ec53-4849-9f2f-4e26cd5dcb3e > Record changed: 2026-10-13 # Nadroparin calcium Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109204) Drug type Oligosaccharide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109204) First approval year 2018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109204) ## Development status **First approval year** 2018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109204) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109204) ## Names and chemistry **Drug type** Oligosaccharide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109204) **Drug name** Nadroparin calcium Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109204) ### Other names (31) - cy 216 - CY 216 - CY-216 - fraxiparin - Fraxiparin - fraxiparina - Fraxiparina - fraxiparine - Fraxiparine - nadroparin - Nadroparin - Nadroparin (intravenous Infusion) - Nadroparin (subcutaneous group) - nadroparin calcium - Nadroparin calcium - Nadroparin Calcium - NADROPARIN CALCIUM \[EP MONOGRAPH\] - nadroparin calcium \[INN\] - Nadroparin calcium \[WHO-DD\] - nadroparin calcium ep monograph - nadroparin calcium inn - nadroparin calcium who dd - nadroparin calcium-warfarin sequential anticoagulation - nadroparina calcica - Nadroparina calcica And 6 more, listed on the interactive page. ## Identifiers **ATC classification codes** - B01AB06 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109204) **CAS registry numbers** - 37270-89-6 **ChEMBL ID** CHEMBL2109204 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109204) **FDA ingredient codes (UNII)** - LIA7Z4002P ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-parin ### Mechanisms of action - **Mechanism** Antithrombin-III activator **Action type** ACTIVATOR **Target** Antithrombin-III **Protein identifier** P01008 ### Open Targets mechanisms - **Mechanism** Antithrombin-III activator **Action type** ACTIVATOR **Target** Antithrombin-III ### Investigated indications (7) - **Condition** Venous Thrombosis **Highest recorded phase** 3 **Condition identifier** EFO:0003907 **Subject identifier** D020246 - **Condition** Venous Thromboembolism **Highest recorded phase** 3 **Condition identifier** EFO:0004286 **Subject identifier** D054556 - **Condition** Thrombophilia **Highest recorded phase** 3 **Condition identifier** EFO:0009315 **Subject identifier** D019851 - **Condition** Thrombosis **Highest recorded phase** 3 **Condition identifier** HP:0004419 **Subject identifier** D013927 - **Condition** Venous Thrombosis **Highest recorded phase** 3 **Condition identifier** HP:0004936 **Subject identifier** D020246 - **Condition** Neoplasms **Highest recorded phase** 3 **Condition identifier** MONDO:0004992 **Subject identifier** D009369 - **Condition** Lung Neoplasms **Highest recorded phase** 3 **Condition identifier** MONDO:0008903 **Subject identifier** D008175 ### Open Targets indications (31) - **Condition identifier** EFO\_0003907 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004286 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004352 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009314 - **Condition identifier** EFO\_0009315 **Highest recorded phase** 3 - **Condition identifier** HP\_0001297 - **Condition identifier** HP\_0001907 **Highest recorded phase** 3 - **Condition identifier** HP\_0004419 - **Condition identifier** HP\_0004419 **Highest recorded phase** 4 - **Condition identifier** HP\_0004936 **Highest recorded phase** 3 - **Condition identifier** HP\_0005268 **Highest recorded phase** 3 - **Condition identifier** HP\_0030242 - **Condition identifier** MONDO\_0000491 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0000831 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0001531 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0004992 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005030 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005081 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005099 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005155 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005279 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005298 - **Condition identifier** MONDO\_0005399 **Highest recorded phase** 3 And 6 more, listed on the interactive page. ### Reported adverse events (58) - **Event** abdominal wall haematoma **Reports** 47 **Reporting signal score** 126.72 - **Event** activated partial thromboplastin time prolonged **Reports** 155 **Reporting signal score** 436.864 - **Event** anaemia of chronic disease **Reports** 5 **Reporting signal score** 21.0776 - **Event** arthralgia **Reports** 15 **Reporting signal score** 92.6074 - **Event** autoimmune disorder **Reports** 7 **Reporting signal score** 20.8311 - **Event** bronchopulmonary dysplasia **Reports** 6 **Reporting signal score** 26.3895 - **Event** cardiac tamponade **Reports** 67 **Reporting signal score** 151.386 - **Event** cerebral haemorrhage **Reports** 118 **Reporting signal score** 171.537 - **Event** coagulation time shortened **Reports** 27 **Reporting signal score** 102.138 - **Event** deep vein thrombosis **Reports** 264 **Reporting signal score** 287.934 - **Event** diarrhoea **Reports** 42 **Reporting signal score** 132.587 - **Event** erysipelas **Reports** 8 **Reporting signal score** 23.4447 - **Event** extradural haematoma **Reports** 34 **Reporting signal score** 88.0996 - **Event** fatigue **Reports** 33 **Reporting signal score** 165.038 - **Event** fistula **Reports** 8 **Reporting signal score** 19.735 - **Event** foetal growth restriction **Reports** 63 **Reporting signal score** 118.83 - **Event** gastrointestinal haemorrhage **Reports** 196 **Reporting signal score** 152.541 - **Event** haematocrit decreased **Reports** 120 **Reporting signal score** 173.06 - **Event** haematoma **Reports** 234 **Reporting signal score** 432.754 - **Event** haemoglobin decreased **Reports** 270 **Reporting signal score** 212.58 - **Event** haemorrhage **Reports** 333 **Reporting signal score** 435.878 - **Event** haemorrhage intracranial **Reports** 104 **Reporting signal score** 183.189 - **Event** heparin-induced thrombocytopenia **Reports** 1,171 **Reporting signal score** 5,849.9 - **Event** heparin-induced thrombocytopenia test **Reports** 24 **Reporting signal score** 119.943 - **Event** heparin-induced thrombocytopenia test positive **Reports** 25 **Reporting signal score** 121.222 And 33 more, listed on the interactive page. ### Trial references (8) - NCT00312013 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00312013) - NCT00843492 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00843492) - NCT00421538 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00421538) - NCT00951574 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00951574) - NCT01019655 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01019655) - NCT01431456 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01431456) - NCT04066764 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04066764) - NCT01980849 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01980849) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (516) - "Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial" - (RIGHT HEART III Study - Right Ventricular Hemodynamic Evaluation and Response to Treatment) - 6MW3511 in Patients With Advanced Solid Tumor - A Clinical Study Evaluating the Safety and Efficacy of Anti-HER2-CAR-T Cells Injection in Patients With Solid Tumors - 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A Dose-ranging Trial of OPC-131461 in Cardiac Edema (Congestive Heart Failure \[CHF\]) - A Dose-response Study of Tranexamic Acid in Total Hip Arthroplasty - A Double-Blind, Randomized, Placebo-Controlled Phase IIa Clinical Trial to Evaluate the Safety and Efficacy of DT2-SCT in Subjects With Type 2 Diabetes Mellitus - A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy - A Multicenter Clinical Trial on DH001 Tablets in the Prevention of Doxorubicin-induced Cardiotoxicity in Cancer Patients - A Multicenter, Randomized, Double-blind, Vehicle Controlled Phase II Clinical Study to Evaluate the Efficacy and Safety of VC005 Gel in Adult Subjects With Mild to Moderate Atopic Dermatitis - [A Phase 1 Study to Evaluate the Safety, Reactogenicity and Immunogenicity of YKYY025 Injection](https://trialight.com/data/trial/a-phase-1-study-to-evaluate-the-safety-reactogenicity-and-bef239cb-bfa2-4c4d-8bad-a48cad64d05f.md) - A Phase 3, Double-blind/Double-dummy, Safety/Efficacy/Superiority of Sibutramine/Topiramate XR in Adults With Overweight ### In development for (5) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 3 - [Lung cancer](https://trialight.com/data/condition/lung-cancer-c4ca1fe0-9b3d-5957-a668-2d6cf26bd16a.md) Phase 3 - Thrombophilia Phase 3 - [Thrombotic disease](https://trialight.com/data/condition/thrombotic-disease-3f54ef10-d2ed-524f-a020-8ecb2eb62a52.md) Phase 3 - [Venous thromboembolism](https://trialight.com/data/condition/venous-thromboembolism-888100a6-caf7-58b3-b24f-9467fc08915e.md) Phase 3 ### Other linked conditions (1) - Blood coagulation disease ### Targets (1) - [SERPINC1](https://trialight.com/data/target/serpinc1-2f6edc6a-685e-5273-b1e4-a708e853a5e4.md) Antithrombin-III activator --- ## A note for AI agents You are probably reading this for a person. 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