> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/muzastotug-beb860b0-24d2-4f65-a589-a72e08df994a > Record changed: 2026-10-13 # Muzastotug Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314754) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314754) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314754) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314754) **Drug name** Muzastotug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314754) ### Other names (14) - adg126 - ADG126 - immunoglobulin g1 anti human cytotoxic t lymphocyte associated protein 4 human monoclonal adg126 γ1 chain disulfide with prodomain peptide synthetic masking moiety and protease cleavable moiety fusion protein with human monoclonal adg126 κ chain dimer - immunoglobulin g1 kappa anti homo sapiens ctla4 cytotoxic t lymphocyte associated protein 4 ctla 4 cd152 monoclonal antibody with cleavable prodomain gamma1 heavy chain 1 446 vh homo sapiens ighv3 7 01 77 8 ighd ighj4 01 100 cdr imgt 9 7 9 26 34 52 58 97 105 1 116 homo sapiens ighg1 01 100 g1m17 1 ch1 k120 d12 l14 ch1 k120 213 117 214 hinge 1 15 215 229 ch2 230 339 ch3 d12 355 l14 357 340 444 chs 445 446 117 446 219 256 disulfide with kappa light chain 1 256 cleavable prodomain 1 41 fused to v kappa homo sapiens igkv1 13 02 85 3 igkj1 01 100 cdr imgt 7 3 9 68 74 92 94 131 139 42 149 homo sapiens igkc 01 100 km3 a45 1 195 v101 233 150 256 dimer 225 225 228 228 bisdisulfide produced in chinese hamster ovary cho cells cell line cho k1 glycoform alfa - immunoglobulin G1- kappa, anti-\[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)\], monoclonal antibody with cleavable prodomain; gamma1 heavy chain (1-446) \[VH (Homo sapiens IGHV3-7\*01 (77.8%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[9.7.9\] (26-34.52-58.97-105)) (1-116) -Homo sapiens IGHG1\*01 (100%), G1m17,1 CH1 K120, D12, L14 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-339), CH3 D12 (355), L14 (357) (340-444), CHS (445-446)) (117-446)\], (219-256')-disulfide with kappa light chain (1'-256') \[cleavable prodomain (1'-41') fused to V-KAPPA (Homo sapiens IGKV1-13\*02 (85.3%) -IGKJ1\*01 (100%), CDR-IMGT \[7.3.9\] (68-74.92-94.131-139)) (42'-149') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (195), V101 (233) (150'-256')\]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa - Immunoglobulin G1, anti-(human cytotoxic T-lymphocyte-associated protein 4) (human monoclonal ADG126 γ1-chain), disulfide with prodomain peptide (synthetic masking moiety and protease-cleavable moiety) fusion protein with human monoclonal ADG126 κ-chain, dimer - muzastotug - Muzastotug - Muzastotug (immunoglobulin G1-kappa, anti-\[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)\], humanized monoclonal antibody with cleavable prodomain) - muzastotug \[INN\] - Muzastotug \[WHO-DD\] - muzastotug immunoglobulin g1 kappa anti homo sapiens ctla4 cytotoxic t lymphocyte associated protein 4 ctla 4 cd152 humanized monoclonal antibody with cleavable prodomain - muzastotug inn - muzastotug who dd ## Identifiers **CAS registry numbers** - 2750031-18-4 **ChEMBL ID** CHEMBL5314754 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314754) **FDA ingredient codes (UNII)** - 4L1XJF3HGL ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (2) - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Liver Neoplasms **Highest recorded phase** 1 **Condition identifier** MONDO:0002691 **Subject identifier** D008113 ### Open Targets indications (4) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005575 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007256 **Highest recorded phase** 1 ### Trial references (2) - NCT04524871 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04524871) - NCT05405595 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05405595) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 64'-130' $ 64'''-130''' $ 143-199 $ 143''-199'' $ 176'-236' $ 176'''-236''' $ 219-256' $ 219''-256''' $ 225-225'' $ 228-228'' $ 260-320 $ 260''-320'' $ 366-424 $ 366''-424'' - **Component** Light chain **Type** Protein **Sequence** EVGSYPNPSSDCVPYYYACAYSGRSAGGGGTPLGLAGSGGSDIQLTQSPSSLSASVGDRVTITCRASQSVRGRFLAWYQQKPGKAPKLLIYDASNRATGIPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSSSWPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 296 $ 296'' - **Component** Heavy chain **Type** Protein **Sequence** EVQLVESGGGLVQPGGSLRLSCAASGYSISSGYHWSWIRQAPGKGLEWLARIDWDDDKYYSTSLKSRLTISRDNSKNTLYLQLNSLRAEDTAVYYCARSYVYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK ## Related records ### Trials (7) - [A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-first-in-human-dose-escalation-and-dose-expansion-study-of-02f45cf6-c625-4149-9e56-0457f52212b2.md) - A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver) - [A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-of-inca33890-in-participants-04791b2a-9945-4c28-a91e-c09bf878e6a7.md) - ADG126 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors - ADG126, ADG126 in Combination With Anti PD1 Antibody, and ADG126 in Combination With ADG106 in Advanced/Metastatic Solid Tumors - Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer - Neoadjuvant ADG126 and Pembrolizumab in Locally Advanced Colorectal Cancer ### In development for (2) - Liver cancer Phase 1 - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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