> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/muvalaplin-21088c29-3f3d-47df-8540-cf6e2ae2beff
> Record changed: 2026-10-13
# Muvalaplin
Highest phase reached
Phase 2
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802585)
Drug type
Small molecule
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802585)
## Development status
**Listing at source**
Listed
**Highest phase reached**
Phase 2
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802585)
## Names and chemistry
**Drug type**
Small molecule
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802585)
**Drug name**
Muvalaplin
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802585)
**Molecular weight**
710.92
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802585)
**Structure (SMILES)**
O=C(O)\[C@@H\](Cc1cccc(CN(Cc2cccc(C\[C@H\](C(=O)O)\[C@H\]3CCNC3)c2)Cc2cccc(C\[C@H\](C(=O)O)\[C@H\]3CCNC3)c2)c1)\[C@H\]1CCNC1
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802585)
### Other names (19)
- (13R,2S,10S,113R)-6-\[(3-{(2S)-2-carboxy-2-\[(3R)-pyrrolidin-3-yl\]ethyl}phenyl)methyl\]-6-aza-1,11(3)-dipyrrolidina-4,8(1,3)-dibenzenaundecaphane-2,10-dicarboxylic acid
- 1 sup 3 sup r 2s 10s 11 sup 3 sup r 6 3 2s 2 carboxy 2 3r pyrrolidin 3 yl ethyl phenyl methyl 6 aza 1 11 3 dipyrrolidina 4 8 1 3 dibenzenaundecaphane 2 10 dicarboxylic acid
- ly 3473329
- LY-3473329
- ly3473329
- Ly3473329
- LY3473329
- muvalaplin
- Muvalaplin
- muvalaplin \[INN\]
- MUVALAPLIN \[USAN\]
- Muvalaplin \[WHO-DD\]
- muvalaplin inn
- muvalaplin usan
- muvalaplin who dd
- muvalaplina
- Muvalaplina
- muvalapline
- Muvalapline
## Identifiers
**CAS registry numbers**
- 2565656-70-2
**ChEMBL ID**
CHEMBL4802585
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802585)
**InChIKey**
BRLGERLDHZRETI-BGBFCPIGSA-N
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802585)
**PubChem compound IDs**
- 155369486
**FDA ingredient codes (UNII)**
- HSU2KY4EFK
## Regulatory information
### Other regulatory facts
**First in class**
No
**Orphan designation**
No
## Pharmacology
### Drug classification
**Pharmacology name**
muvalaplin
**Type**
Synthetic organic
**Drug name stem**
\-aplin; -laplin
### Investigated indications (2)
- **Condition**
Coronary Artery Disease
**Highest recorded phase**
1
**Condition identifier**
EFO:0001645
**Subject identifier**
D003324
- **Condition**
Renal Insufficiency
**Highest recorded phase**
1
**Condition identifier**
HP:0000083
**Subject identifier**
D051437
### Open Targets indications (5)
- **Condition identifier**
EFO\_0000319
**Highest recorded phase**
2
- **Condition identifier**
EFO\_0001645
- **Condition identifier**
HP\_0000083
**Highest recorded phase**
1
- **Condition identifier**
MONDO\_0004995
**Highest recorded phase**
2
- **Condition identifier**
MONDO\_0005010
### Trial references
- NCT05778864
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05778864)
## Chemical properties
**Hydrogen bond acceptors**
7
**Hydrogen bond donors**
6
**Polar surface area**
151.23
**Calculated partition coefficient (ALogP)**
4.45
**Calculated partition coefficient (XLogP)**
\-2.8
**Prodrug**
No
**Chirality**
Single enantiomer
**Inorganic**
No
**Rule-of-five violations**
2
**Rotatable bonds**
18
**Heavy atoms**
52
**Molecular formula**
C42H54N4O6
**Monoisotopic mass**
710.40433546
**Natural product**
No
## Related records
### Trials (6)
- A Study of Carbon-14-Labelled \[14C\] LY3473329 in Healthy Male Participants
- A Study of LY3473329 in Adult Participants With Elevated Lipoprotein(a) at High Risk for Cardiovascular Events
- A Study of LY3473329 in Healthy Japanese Participants
- A Study of LY3473329 in Healthy Participants
- A Study of LY3473329 in Participants With Impaired and Normal Renal Function
- [Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)](https://trialight.com/data/trial/assessing-the-impact-of-muvalaplin-on-major-cardiovascular-e88d9dae-5619-485f-a493-5e205b266e64.md)
### In development for (3)
- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 2
- [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) Phase 1
- [Kidney failure](https://trialight.com/data/condition/kidney-failure-f26737b4-3a55-50be-b6c3-b76514cb5067.md) Phase 1
---
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