> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/muramyl-dipeptide-9831c7ba-8a15-402c-8de7-eef1bb5f5ed8 > Record changed: 2026-10-13 # Muramyl dipeptide Highest phase reached Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1779325) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1779325) ## Development status **Listing at source** Listed **Highest phase reached** Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1779325) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1779325) **Drug name** Muramyl dipeptide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1779325) **Molecular weight** 492.48 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1779325) **Structure (SMILES)** CC(=O)N\[C@H\]1C(O)O\[C@H\](CO)\[C@@H\](O)\[C@@H\]1O\[C@H\](C)C(=O)N\[C@@H\](C)C(=O)N\[C@H\](CCC(=O)O)C(N)=O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1779325) ### Other names (28) - acetylmuramyl alanyl isoglutamine - acetylmuramyl l alanyl d isoglutamine - Acetylmuramyl-alanyl-isoglutamine - ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE - adagloxad simolenin with adjuvant - matrix m1 adjuvant for bedside mixing - MATRIX-M1 (Adjuvant) For Bedside Mixing - Mdp (adjuvant) - mdp adjuvant - mFOLFOX (adjuvant) - MOTS-c (MDP) - muramyl dipeptide - Muramyl dipeptide - MURAMYL DIPEPTIDE \[MI\] - muramyl dipeptide mi - n acetylmuramoyl alanyl d isoglutamine - n acetylmuramyl dipeptide - n acetylmuramyl l alanine d isogln - n acetylmuramyl l alanyl d isoglutamine - N-(ACETYLMURAMOYL)ALANYL-D-ISOGLUTAMINE - N-(ACETYLMURAMYL)-L-ALANYL-D-ISOGLUTAMINE - N-acetylmuramyl dipeptide - N-ACETYLMURAMYL-L-ALANINE-D-ISOGLN - n2 n n acetylmuramoyl l alanyl d alpha glutamine - N2-(N-(N-ACETYLMURAMOYL)-L-ALANYL)-D-ALPHA-GLUTAMINE And 3 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 53678-77-6 **ChEMBL ID** CHEMBL1779325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1779325) **InChIKey** BSOQXXWZTUDTEL-QAQREVAFSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1779325) **FDA ingredient codes (UNII)** - 2U7S2HVO96 ### PubChem compound IDs (2) - 11620162 - 91667728 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** muramyl dipeptide **Type** Natural product **Drug name stem** \-tide ### Mechanisms of action (2) - **Action** Agonist **Action type** Agonist **Target** NLRP1 **Gene symbol** NLRP1 **Protein identifier** Q9C000 - **Action** Agonist **Action type** Agonist **Target** nucleotide binding oligomerization domain containing 2 **Gene symbol** NOD2 **Protein identifier** Q9HC29 ### Investigated indications - **Condition** HIV Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000764 **Subject identifier** D015658 ### Trial references - NCT00001042 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001042) ## Chemical properties **Hydrogen bond acceptors** 10 **Hydrogen bond donors** 8 **Polar surface area** 246.84 **Calculated partition coefficient (ALogP)** \-4.33 **Calculated partition coefficient (XLogP)** \-3.7 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 12 **Heavy atoms** 34 **Molecular formula** C19H32N4O11 **Monoisotopic mass** 492.20675785 **Natural product** No ## Evidence counts **Recorded assays** 177 **Active assays** 5 ### Active assay types - Confirmatory ## Pharmacologic actions - Adjuvants, Immunologic Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000276.html) ## Related records ### Trials (458) - A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children - A Clinical Study Comparing Anti-HER2 Therapy Combined With Chemotherapy to Chemotherapy Alone as Adjuvant Therapy Following Surgery for Stage IB-II Gastric Cancer With High HER2 Expression. - A Clinical Study for Inactivated Vaccine Against EV71 - A Clinical Trial on Combined (Neo-)Adjuvant Intravenous Plus Intracranial Administration of Ipilimumab and Nivolumab in Recurrent Glioblastoma - A Comparison of Laparoscopic With Open Distal Gastrectomy in Advanced Gastric Cancer After Neoadjuvant Chemotherapy - A Double-Dose Safety Study of An Influenza Vaccine (Multimeric-001) Injected to Elderly Volunteers - [A First-in-human Study of IBI343 in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors](https://trialight.com/data/trial/a-first-in-human-study-of-ibi343-in-subjects-with-locally-4e81f168-2d84-4a0c-aacb-e72520c7df80.md) - 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A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants - A Phase Ⅱ Study of XELOX Chemotherapy With or Without Surgery of Primary Lesion for Colon Cancer Patients - A Phase II Trial of Perioperative Adebrelimab Combined With XELOX in Resectable Locally Advanced Gastric/Gastroesophageal Junction Cancer (GC/GEJC) - A Phase II, Safety and Efficacy Study of Inactivated EV 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants - A Platform Trial for Personalized and Adaptive Therapies in Hepatocellular Carcinoma - A Prospective Multicenter Study: Ivosimab + Chemotherapy as Neoadjuvant for Resectable pMMR/MSS CRC Liver Mets ### In development for (1) - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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