> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/mufemilast-af018a46-93c7-4d17-8693-1a601503e0e5
> Record changed: 2026-10-29

# Mufemilast

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095240)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095240)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095240)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095240)

**Drug name**

Mufemilast

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095240)

**Molecular weight**

466.54

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095240)

**Structure (SMILES)**

CCOc1cc(\[C@@H\](CS(C)(=O)=O)N2C(=O)c3csc(NC(C)=O)c3C2=O)ccc1OC

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095240)

### Other names (17)

- 15mg hemay005
- 15mg Hemay005
- 60mg Hemay005
- hemay 005
- HEMAY-005
- hemay005
- Hemay005
- HEMAY005
- Hemay005 60 mg
- Hemay005 tablet
- Hemay005 tablets
- mufemilast
- Mufemilast
- mufemilast \[INN\]
- Mufemilast \[WHO-DD\]
- mufemilast inn
- mufemilast who dd

## Identifiers

**CAS registry numbers**

- 1255909-03-5

**ChEMBL ID**

CHEMBL5095240

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095240)

**InChIKey**

PRSNGWLHNWGOKD-CQSZACIVSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095240)

**PubChem compound IDs**

- 137355584

**FDA ingredient codes (UNII)**

- 4QX9BK9E7P

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

mufemilast

**Type**

Synthetic organic

**Drug name stem**

\-ast

**Approval recorded by Guide to Pharmacology**

Yes

### Investigated indications (5)

- **Condition**  
Dermatitis, Atopic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000274

**Subject identifier**  
D003876
- **Condition**  
Psoriasis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000676

**Subject identifier**  
D011565
- **Condition**  
Colitis, Ulcerative

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000729

**Subject identifier**  
D003093
- **Condition**  
Behcet Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003780

**Subject identifier**  
D001528
- **Condition**  
Spondylitis, Ankylosing

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003898

**Subject identifier**  
D013167

### Open Targets indications (13)

- **Condition identifier**  
EFO\_0000274

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000676

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000729

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003780

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003898

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001494

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0000155

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004980

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005002

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005083

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005101

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005306

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007191

**Highest recorded phase**  
3

### Trial references (12)

- NCT03007810  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03007810)
- NCT03570346  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03570346)
- NCT03577626  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03577626)
- NCT04102241  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04102241)
- NCT04837235  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04837235)
- NCT04839328  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04839328)
- NCT06376474  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06376474)
- NCT06380153  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06380153)
- NCT04609397  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04609397)
- NCT05407246  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05407246)
- NCT05486104  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05486104)
- NCT05769946  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05769946)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

1

**Polar surface area**

119.08

**Calculated partition coefficient (ALogP)**

2.5

**Calculated partition coefficient (XLogP)**

1.9

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

8

**Heavy atoms**

31

**Molecular formula**

C20H22N2O7S2

**Monoisotopic mass**

466.08684339

**Natural product**

No

## Evidence counts

**Recorded assays**

5

**Active assays**

5

### Active assay types

- Confirmatory

## Pharmacologic actions

- Dermatologic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D003879.html)
- Phosphodiesterase 4 Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D058988.html)

## Related records

### Trials (20)

- A Food Effect Study to Assess Pharmacokinetics of Hemay005 in Healthy Volunteers
- A Phase Ⅲ Efficacy and Safety Study of Hemay005 in Subjects With Moderate to Severe Plaque Psoriasis
- A Study of Efficacy and Safety of Hemay005 Tablets in Patients With Behçet's Disease
- A Study of Hemay005 in Adult With Atopic Dermatitis
- A Study to Evaluate the Effects of Single and Multiple Doses of Hemay005 Tablets in Health Caucasian Adult Volunteers
- A Study to Evaluate the Efficacy and Safety of Hemay005 in the Treatment of Behçet Disease
- A Study to Investigate the Biomarkers of Hemay005 in Adult Participants With Moderate to Severe COPD
- Bioequivalence Test of Hemay005 Tablets
- Efficacy and Safety Study of Hemay005 in Subjects With Moderate to Severe Plaque Psoriasis
- [Evaluation the Safety of hemay005 Tablets](https://trialight.com/data/trial/evaluation-the-safety-of-hemay005-tablets-38118849-d0a8-4740-9e99-89a06b0c24aa.md)
- Hemay005 for the Treatment of Chinese Moderately to Severely Active Ulcerative Colitis
- In Vivo Mass Balance Study of \[14C\]Hemay005
- Multiple Ascending Dose Study to Assess Safety and Pharmacokinetics of Hemay005 In Healthy Subjects
- Multiple Ascending Dose Study to Assess Safety and Pharmacokinetics of Hemay005 In Healthy Subjects
- Pharmacokinetic Interactions Between Hemay005 Tablets and Midazolam Maleate Tablets
- Phase II Study of Hemay005 in Patients With Active Ankylosing Spondylitis
- Phase II Study of Hemay005 in Patients With Active Ulcerative Colitis
- Safety and Pharmacokinetics of Hemay005 In Healthy Male Subjects
- To Evaluate the Pharmacokinetics of Hemay005 Tablets in Patients With Renal Impairment
- To Evaluate the Pharmacokinetics of Hemay005 Tablets in Subjects With Liver Damage

### In development for (5)

- [Ankylosing spondylitis](https://trialight.com/data/condition/ankylosing-spondylitis-9b1fe73f-f462-5baf-85b0-5cbf33725458.md) Phase 2
- [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2
- Behcet disease Phase 2
- [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 3
- [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 2

---

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